171–180 of 227 posts
If you haven't experienced it yet, I highly recommend you check out 17776: What Football Will Look Like in the Future [0]. It explores what happens if humans stop aging/dying/being born, narrated by a few cheeky, sentient space probes. [0] https://www.sbnation.com/a/17776-football
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Cells are self-replacing under the control of their own DNA; not pumped out of a factory. Slowly accumulating errors in the DNA can compromise the ability of cells to make good copies of themselves, potentially leading to cancer calls instead.
Right, that makes sense, but that's not really relevant to what I assume is the half life of a specific strand of DNA, right?
Error rate during active lifespan is real. Gamma ray probably is the largest contributor of active (or even inactive) DNA being disturbed.
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Not all forms of death are necessarily equivalent. By all accounts, covid seems like a relatively long and painful one, slowly suffocating to death.
I think dying alone is much worse than dying with your family suffocating to death.
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Oh man, you wouldn't believe the flak I got for arguing that 90+ year olds wanting to see their family during COVID restrictions was actually a rational decision for them. They had a much higher annual risk of dying anyway than they did of catching and dying from COVID given the prevalence rates at the time and assuming standard family gathering sizes. I'm not even sure their risk was strictly greater given the affec…
Not all forms of death are necessarily equivalent. By all accounts, covid seems like a relatively long and painful one, slowly suffocating to death.
In a Wondrium lecture on genetics and evolution, this question was also discussed. A compelling (but unproven) explanation for our “age limit” is that any genetic trait that improves your chances before reproduction at the cost of your chances after reproduction (and raising your offspring) will benefit your genes and thus will “win” in the long run. If this is an important effect, it will be very hard to defeat.
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I think dying alone is much worse than dying with your family suffocating to death.
There are portions of the world where we don't have our older family members off living on their own.
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Rural Greek Orthodox tend to have a lot of fasting days (IIRC about 200 in a year), and caloric restriction (CR) is a well known mechanism that slows down aging in many animals. Of course, humans are long lived by natural standards, so the effect of CR on lifespan may be much smaller than in mice or worms, but I would still expect someone-who-fasts-regularly-but-isn't-malnourished to be healthier than an average West…
Did you mean to reply to me or a different comment?
Greek islands are one of the putative Blue zones, so this was the anchor of my comment.
Extending life is a fantasy of the middle-aged who are still feeling great and imagine it forever. You won't get it until you pass a certain year, where like an old car, things suddenly start failing one at a time where everything was fine for years. Diseases, illnesses like Covid can cause radical aging, one year you are turning 55 but Covid now makes it like you are 65 because all your organs, body and brain have b…
Take the guy with a pig heart and extend that tech 60 years out, then take the richest man on earth who will spare no expense for him and his statistically significant pool of people willing to undergo this experiment with him. The brain and circulatory system and are going to be some of the limiting factors to this approach, but in my uneducated opinion would have a good shot at creating the oldest people to live, albeit with a high dropout rate.
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Are you serious? You’ve left behind petty stereotyping and are boldly venturing into bigotry here.
My grandparents are now 95 and 96 (just shy of their 75th wedding anniversary). They are wonderful people, but it is clear that life is hard for them now. They have chronic pain and nothing can really be done about it. They have very limited opportunities for enjoyment or activity. Watching them, and also my mother struggle with health issues at 73, has really changed my perspective on aging. I am very focused on enj…
Dr. Sinclair's book Lifespan ( https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150... ) talks about extending the health span of people. I've been personally taking 1g/day of NMN for almost 3 years now, and I feel like aging has paused or is going backwards slowly.
I am willing to bet it will do more for you than taking NMN.
Peter Attia has discussed this with folks who know a lot more than Sinclair and they have concluded there is no evidence it works. The number one thing you can do to extend lifespan is exercise.