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Does the human lifespan have a limit?
151–160 of 227 posts
Re: Does the human lifespan have a limit?
#152My grandparents are now 95 and 96 (just shy of their 75th wedding anniversary). They are wonderful people, but it is clear that life is hard for them now. They have chronic pain and nothing can really be done about it. They have very limited opportunities for enjoyment or activity. Watching them, and also my mother struggle with health issues at 73, has really changed my perspective on aging. I am very focused on enj…
Dr. Sinclair's book Lifespan ( https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150... ) talks about extending the health span of people. I've been personally taking 1g/day of NMN for almost 3 years now, and I feel like aging has paused or is going backwards slowly.
I am willing to wager that Dr Sinclair is just peddling nonsense to make his million bucks and exit quickly.
Re: Does the human lifespan have a limit?
#153Earlier quoted context omitted.
Where can you get NMN?
Don't bother. Sinclair is considered a quack by even some life-extension enthusiasts. He owns part of the company that makes patented NMN which is just another form of NR which is a another form of very cheap Niacin. He also owns part of the company that claims he is rolling back his biological clock. That's not science, that's marketing and profiteering. NAD production slows down with age and illness. All he is doin…
I am doing some experiments with NR (no Sinclair in the business chain AFAIK) and pterostilbene and my ability to exercise has improved noticeably. I am 43 and I used to be fairly sore after a strenuous 60 minute exercise - especially my sinews were bad. This wasn't getting any better with more exercise, actually it was slowly getting worse with age, to the degree that I wasn't able to exercise in two consecutive days and sometimes I had to wait until the third day to go to the gym again. (To be clear, I am neither fat nor riddled with any serious disease.)
Nowadays the small pains and aches go away in a few hours, like when I was some 15 years younger. But if I stop the supplementation, the situation reverts to the old bad standard within a month or so.
I also noticed some effect on my visual acuity.
I know this is N == 1, hard to measure precisely and subject to a possible placebo effect.
Re: Does the human lifespan have a limit?
#154And hundreds of people reached the rarefied ranks of the supercentenarians — aged 110 or older — although demographers have validated the records of only a fraction of them. Um, yes. A few years ago, the city government of Tokyo sent people to visit everyone who reported an age over 100, to see what they were doing right. What they found was a lot of pension fraud. "To date, the authorities have been unable to find m…
The whole Blue Zones thing is pretty funny. https://en.wikipedia.org/wiki/Blue_zone Only Loma Linda seems like it might not be the result of fraud — and that’s only because it’s a haven for a kooky religion. The whole life-extension thing is funny. I wonder if people realize what the world is going to be like 70+ years from now and how miserable it’s going to be for anyone over 100 who’s not rich? I think about my 95…
Rural Greek Orthodox tend to have a lot of fasting days (IIRC about 200 in a year), and caloric restriction (CR) is a well known mechanism that slows down aging in many animals.
Of course, humans are long lived by natural standards, so the effect of CR on lifespan may be much smaller than in mice or worms, but I would still expect someone-who-fasts-regularly-but-isn't-malnourished to be healthier than an average Western person. Which usually translates into living longer.
Re: Does the human lifespan have a limit?
#155Earlier quoted context omitted.
The whole Blue Zones thing is pretty funny. https://en.wikipedia.org/wiki/Blue_zone Only Loma Linda seems like it might not be the result of fraud — and that’s only because it’s a haven for a kooky religion. The whole life-extension thing is funny. I wonder if people realize what the world is going to be like 70+ years from now and how miserable it’s going to be for anyone over 100 who’s not rich? I think about my 95…
Oh man, you wouldn't believe the flak I got for arguing that 90+ year olds wanting to see their family during COVID restrictions was actually a rational decision for them. They had a much higher annual risk of dying anyway than they did of catching and dying from COVID given the prevalence rates at the time and assuming standard family gathering sizes. I'm not even sure their risk was strictly greater given the affec…
Not all forms of death are necessarily equivalent. By all accounts, covid seems like a relatively long and painful one, slowly suffocating to death.
Re: Does the human lifespan have a limit?
#156My grandparents are now 95 and 96 (just shy of their 75th wedding anniversary). They are wonderful people, but it is clear that life is hard for them now. They have chronic pain and nothing can really be done about it. They have very limited opportunities for enjoyment or activity. Watching them, and also my mother struggle with health issues at 73, has really changed my perspective on aging. I am very focused on enj…
Eventually we will fix all these issues. The only deaths will be freak accidents or killings/suicides. Youth forever. We're less than a hundred years away from that kind of tech, I believe.
Re: Does the human lifespan have a limit?
#157My grandparents are now 95 and 96 (just shy of their 75th wedding anniversary). They are wonderful people, but it is clear that life is hard for them now. They have chronic pain and nothing can really be done about it. They have very limited opportunities for enjoyment or activity. Watching them, and also my mother struggle with health issues at 73, has really changed my perspective on aging. I am very focused on enj…
Dr. Sinclair's book Lifespan ( https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150... ) talks about extending the health span of people. I've been personally taking 1g/day of NMN for almost 3 years now, and I feel like aging has paused or is going backwards slowly.
He's also launched a podcast-- https://www.youtube.com/c/DavidSinclairPodcast/videos
I find the first 3 episodes to be absolutely stellar and was engrossed the whole hour. Pretty good takeaways.
The more recent ones are a little contentious and, as he himself admits, a little pseudosciency. He even says that these supplements are marginally helpful, and perhaps the most beneficial things is literally to just walk after a meal. Partially as a result, and partially because the recent episodes's concepts weren't explained well, I found myself distracted.
Random-- he makes a comment how the FDA often prematurely bans things e.g. peptides, which greatly hampers researchers' access to these materials.
Re: Does the human lifespan have a limit?
#158Earlier quoted context omitted.
How old are you? How are you gauging “aging has paused or is going backwards slowly”?
Mid 30s. Gauging by how my joints feel and how quickly I recover from physical exercise and injuries.
I’m 38. I’ve beaten the hell out of my poor aging frame. And then fixed a lot of those injuries to my poor aging frame by not playing rugby any more.
All of which to say: there is absolutely no way you are possibly controlling for all variables here. Things off the top of my head that could help with exercise recovery, all of which are more plausible than some poorly tested supplement:
- Changes in exercise type - Changes in exercise duration - Changes in exercise intensity - Changes in exercise form - Weight loss - Sleeping more for better recovery
Re: Does the human lifespan have a limit?
#159Earlier quoted context omitted.
The whole Blue Zones thing is pretty funny. https://en.wikipedia.org/wiki/Blue_zone Only Loma Linda seems like it might not be the result of fraud — and that’s only because it’s a haven for a kooky religion. The whole life-extension thing is funny. I wonder if people realize what the world is going to be like 70+ years from now and how miserable it’s going to be for anyone over 100 who’s not rich? I think about my 95…
Rural Greek Orthodox tend to have a lot of fasting days (IIRC about 200 in a year), and caloric restriction (CR) is a well known mechanism that slows down aging in many animals. Of course, humans are long lived by natural standards, so the effect of CR on lifespan may be much smaller than in mice or worms, but I would still expect someone-who-fasts-regularly-but-isn't-malnourished to be healthier than an average West…
Did you mean to reply to me or a different comment?
Re: Does the human lifespan have a limit?
#160Earlier quoted context omitted.
Neither commenter was advocating for having it both ways. I don't even find them at odds with one another. I happen to agree with both assertions. OP: "millenia old book makes claim about life that is empirically uncontroverted in 2022" – i agree Parent: "the bible is a collection of stories and contradictions should be expected" – i also agree The first half of your comment could indeed be relevant in the right disc…
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Are you serious? You’ve left behind petty stereotyping and are boldly venturing into bigotry here.