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Moderna’s HIV vaccine has officially begun human trials

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Re: Moderna’s HIV vaccine has officially begun human trials

#131

Post by jldugger »

meepmorp wrote: post #115
jldugger wrote: post #90

Earlier quoted context omitted.

> high-risk low-incidence diseases like this conducted If you're asking 'how do we test the vaccine without _trying_ to give people HIV", one option is to give it to a lot of people, and record their outcomes over time. But first you need to prove the vaccine isnt like, super toxic in humans. So you do animal analog tests, then a limited test on humans, aka "Phase 1 trials". A previous article summarizes: > Moderna’s…

That article may be wrong. According to clinicaltrials.gov, they were still recruiting for the HIV trial and the target completion date is April 11, 2023. https://clinicaltrials.gov/ct2/show/NCT05001373?id=NCT050013... Edited because my previous version was possibly wrong.

Okay, well, it still outlines clinical trial phases correctly, right?

Re: Moderna’s HIV vaccine has officially begun human trials

#132

Post by adamrezich »

yakshaving_jgt wrote: post #74
adamrezich wrote: post #18

Earlier quoted context omitted.

what makes you think so? how could the market for this be greater than the market for the covid vaccine? the number of people susceptible to covid is much greater than the number of people susceptible to HIV.

I think the general public’s perception of the consequences of infection are different depending on the disease. I think most people see it as “covid = bad cold; HIV = death”.

but surely more people would say "my lifestyle choices mean that I'm never going to be exposed to HIV so I don't need a vaccine for it" than ditto for covid?

Re: Moderna’s HIV vaccine has officially begun human trials

#133

Post by dpark »

tialaramex wrote: post #89
f6v wrote: post #56

Earlier quoted context omitted.

I think slowly will come the realization that mRNA vaccines aren’t as fast to develop as people thought. Sputnik/AstraZeneca vaccines were released almost at the same time as Moderna/Pfizer. Yes, the latter were first commercial mRNA vaccines, but the technology is nevertheless rather mature. I watched a lecture by the people credited with creating mRNA vaccines and it turns out people have been working on the techno…

Both the Oxford-AstraZeneca vaccine and Sputnik are using a pretty similar trick that gives them the speed-up. They still get to pick an arbitrary sequence, but they're smuggling it inside a virus instead of as mRNA. That's why the codename for the AstraZeneca vaccine is ChAdOx1, it's a Chimp Adenovirus as host for the sequence. Take this mild uninteresting chimpanzee virus, but tweak it to tell human cells to produc…

> and maybe to Chimp Adenoviruses

Which is a major problem with this technique. One of the other vaccines (J&J?) used a relatively harmless human virus and as I recall, some people with previous exposure had no effect from the vaccine.

Re: Moderna’s HIV vaccine has officially begun human trials

#134

Post by hatware »

gitfan86 wrote: post #121
hatware wrote: post #109

Earlier quoted context omitted.

Quoted post unavailable.

That is fine if you think things would have worked out better if we just treated Covid like another strain of the flu. 99% of ER Doctors disagree with you. If you think their opinion doesn't matter, that is fine too, but I don't see why I should ignore their opinions and agree with yours.

No post body was provided.

Re: Moderna’s HIV vaccine has officially begun human trials

#135

Post by hatware »

spywaregorilla wrote: post #128
hatware wrote: post #111

Earlier quoted context omitted.

Quoted post unavailable.

It's a cute common conspiracy theory but it doesn't really hold up. Modern pharma is making progress all the time. E.g. as shown, an HIV vaccine.

No post body was provided.

Re: Moderna’s HIV vaccine has officially begun human trials

#136

Post by dillondoyle »

aleks224 wrote: post #85
mlyle wrote: post #21

Earlier quoted context omitted.

There's some known HIV "bnAbs", or broadly neutralizing antibodies. The thing is, these are not the antibodies most humans develop in response to HIV. Previous HIV vaccine attempts have only done a fair job at eliciting these broadly neutralizing responses. e.g. SAV001, a "whole killed" HIV vaccine, only produces broadly neutralizing antibodies in about a third of recipients (and less broadly neutralizing response in…

>An "elite controller" is a person living with HIV who is able to maintain undetectable viral loads for at least 12 months despite not having started antiretroviral therapy (ART) . Elite controllers are rare: for every two hundred people living with HIV, approximately one may be an elite controller (0.5%). > It is not entirely understood why some patients are able to achieve undetectable viral loads without ART. http…

And undetectable === untransmittable. Just in case people here didn't know.

Re: Moderna’s HIV vaccine has officially begun human trials

#137

Post by khazhoux »

hnarn wrote: post #124
somesanityplz wrote: post #120

Quoted post unavailable.

I have no idea what you’re trying to say.

Sadly, given that it's a new (throwaway?) account used to post in a thread about a vaccine, there's a high chance this is another neo-anti-vaxxer, here to tell us why this is "not a vaccine" and all that.

Re: Moderna’s HIV vaccine has officially begun human trials

#139

Post by meepmorp »

jldugger wrote: post #131
meepmorp wrote: post #115

Earlier quoted context omitted.

That article may be wrong. According to clinicaltrials.gov, they were still recruiting for the HIV trial and the target completion date is April 11, 2023. https://clinicaltrials.gov/ct2/show/NCT05001373?id=NCT050013... Edited because my previous version was possibly wrong.

Okay, well, it still outlines clinical trial phases correctly, right?

Oh, sure, it just seemed odd.

Re: Moderna’s HIV vaccine has officially begun human trials

#140

Post by ifyoubuildit »

copperx wrote: post #119
ifyoubuildit wrote: post #98

Earlier quoted context omitted.

> This is because there generally isn't a known mechanism for vaccines to have long term effects. I know a lot of people believe this, but as a developer who regularly deploys code to production, this mindset blows me away. I'm not saying that being a developer means I know anything about this. I'm well aware of my (our? I don't know what you do) peoples habit of thinking being good at our craft means we're also some…

I'm pretty sure understanding the biology behind it all can help make predictions about the outcome in the same way that you know that merging a pull request isn't going to bring the entire internet down. I mean, it could. But there's no known mechanism that will trigger such an event. That reminds me of the first atomic bomb test. We weren't 100% sure that the atmosphere wasn't going to ignite with an atomic bomb, b…

> I'm pretty sure understanding the biology behind it all can help make predictions about the outcome ...

Of course it can, that's what you use to write your test plan. But I never (ever) rely on those predictions alone. Everyone who has done this long enough knows that if you don't test your code well enough before you push it out, it will fail. Hell, it'll even fail sometimes when you did thoroughly test it.

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