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I would be happy if they cured cancer.
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Moderna’s HIV vaccine has officially begun human trials
111–120 of 490 posts
Re: Moderna’s HIV vaccine has officially begun human trials
#112Earlier quoted context omitted.
> Rather, there would be delta- and omicron-specific vaccine. I think there are -- they just haven't made it through the trials and approval processes yet. These are press releases from Pfizer for whatever it's worth: Omicron: https://www.pfizer.com/news/press-release/press-release-deta... Mentions delta: https://cdn.pfizer.com/pfizercom/2021-07/Delta_Variant_Study...
Yes, but what I meant was those would be already approved.
What's the rationale behind your assertion?
Re: Moderna’s HIV vaccine has officially begun human trials
#113Earlier quoted context omitted.
Regarding your second point, isn’t HIV a preventable disease? In the areas where the prevalence is in double digits, people don’t seem to be using condoms or taking other precautions. Why would they be taking vaccine every year?
It's a lot easier to get folks to agree to one or two shots one time than to convince them to change their sexual practices, one would imagine.
I somewhat agree, but condoms aren’t just for HIV and save from other potentially lethal diseases. So the benefit is just enormous, yet folks still don’t use them. At the same time, look the vaccination rates in the Eastern Europe. I suspect it’s somewhat hard to get people vaccinated against the disease they don’t take seriously. I mean, HIV is horrible. Yet so many people ignore protection.
Re: Moderna’s HIV vaccine has officially begun human trials
#114Earlier quoted context omitted.
Not sure why you’re being downvoted all much… well actually no it’s pretty obvious. I think you’re right though. The current Covid-19 vaccines are proven to lose efficacy over time. Will the same thing happen with this one as well? It’s a good question.
> well actually no it’s pretty obvious If you think they're right you may not understand why the comment is being down voted. > The current Covid-19 vaccines are proven to lose efficacy over time. Will the same thing happen with this one as well? Like with any vaccine: Probably. > It’s a good question It's pretty besides the point. To recycle my car brakes analogy: They also lose efficacy over time, yet are widely co…
Car brake dust is an extremely potent carcinogen, take care when dealing with them.
Re: Moderna’s HIV vaccine has officially begun human trials
#115How are human trials on high-risk low-incidence diseases like this conducted?
> high-risk low-incidence diseases like this conducted If you're asking 'how do we test the vaccine without _trying_ to give people HIV", one option is to give it to a lot of people, and record their outcomes over time. But first you need to prove the vaccine isnt like, super toxic in humans. So you do animal analog tests, then a limited test on humans, aka "Phase 1 trials". A previous article summarizes: > Moderna’s…
That article may be wrong. According to clinicaltrials.gov, they were still recruiting for the HIV trial and the target completion date is April 11, 2023.
https://clinicaltrials.gov/ct2/show/NCT05001373?id=NCT050013...
Edited because my previous version was possibly wrong.
Re: Moderna’s HIV vaccine has officially begun human trials
#116Earlier quoted context omitted.
The slow part is the safety testing right? If we had a robust enough theory of vaccines safety we could reduce that. How are the yearly flu shots tested anyway? Now, I would not take such a HIV shot. But for high risk groups, think promiscious homosexuals, it may eventually be worth it.
If we had robust enough theory of vaccine testing it wouldn’t matter what kind of vaccine you develop, right?
Maybe, maybe not? Mrna vaccines are very customizable so they could be specifically engineered to avoid known safety issues for example.
Re: Moderna’s HIV vaccine has officially begun human trials
#117Earlier quoted context omitted.
One reason is that mRNA vaccines can be developed much faster than traditional vaccines. So the idea is you have a better chance of "outrunning" a strain.
I think slowly will come the realization that mRNA vaccines aren’t as fast to develop as people thought. Sputnik/AstraZeneca vaccines were released almost at the same time as Moderna/Pfizer. Yes, the latter were first commercial mRNA vaccines, but the technology is nevertheless rather mature. I watched a lecture by the people credited with creating mRNA vaccines and it turns out people have been working on the techno…
The way I understand is that that design and manufacturing is the smaller share of the lead time for mRNA and non-mRNA. The pre-clinic and clinic trials along with any regulatory delay take most of the time. Still mRNA vaccines are better and cheaper than conventional vaccines after CAPEX is done. Both Moderna and Pfizer have trials running for Omicron.
Re: Moderna’s HIV vaccine has officially begun human trials
#118Earlier quoted context omitted.
> Rather, there would be delta- and omicron-specific vaccine. I think there are -- they just haven't made it through the trials and approval processes yet. These are press releases from Pfizer for whatever it's worth: Omicron: https://www.pfizer.com/news/press-release/press-release-deta... Mentions delta: https://cdn.pfizer.com/pfizercom/2021-07/Delta_Variant_Study...
Yes, but what I meant was those would be already approved.
Regulation will take time to catch up. We manage to create and approve a flu vaccine every year, and that's likely because the general process has been approved, and so each iteration is fast tracked. I don't think that's the case with mRNA vaccines yet.
Re: Moderna’s HIV vaccine has officially begun human trials
#119Earlier quoted context omitted.
Knowing long-term effects (1+ years) is not a precondition of approval for most vaccines. It just so happens that vaccines usually take a long time for approval, so we end up knowing long-term effects as a side effect. This is because there generally isn't a known mechanism for vaccines to have long term effects. Not ruling out the possibility, but we understand how vaccines work pretty well. Also, most vaccines are…
> This is because there generally isn't a known mechanism for vaccines to have long term effects. I know a lot of people believe this, but as a developer who regularly deploys code to production, this mindset blows me away. I'm not saying that being a developer means I know anything about this. I'm well aware of my (our? I don't know what you do) peoples habit of thinking being good at our craft means we're also some…
I'm pretty sure understanding the biology behind it all can help make predictions about the outcome in the same way that you know that merging a pull request isn't going to bring the entire internet down. I mean, it could. But there's no known mechanism that will trigger such an event.
That reminds me of the first atomic bomb test. We weren't 100% sure that the atmosphere wasn't going to ignite with an atomic bomb, but those that knew the physics knew it was almost impossible.
> "If, after calculation, [Compton] said, it were proved that the chances were more than approximately three in one million that the earth would be vaporized by the atomic explosion, he would not proceed with the project. Calculation proved the figures slightly less -- and the project continued."
https://www.insidescience.org/manhattan-project-legacy/atmos...
Re: Moderna’s HIV vaccine has officially begun human trials
#120No post body was provided.