Japanese scientists develop vaccine to eliminate cells behind aging • Hacker News Board

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#121

Post by pininja » Sun, Dec 12, 2021, 6:11 PM UTC

majkinetor wrote: post #91

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

I am pretty sure this would lead to more faster aging. Immune system ages itself, and collateral damage it does during fight response is not 0. There is limited amount of resources for stuff, it the only stuff you do is fighting various shit around, the body will probably turn off other non important stuff for immediate survival. Also, you should think sometimes about aspirin and Spanish fever phenomena.

For people like me who weren’t familiar, aspirin toxicity may have led to the extreme mortality at the peak of the Spanish flu. [0]

> The hypothesis presented herein is that aspirin contributed to the incidence and severity of viral pathology, bacterial infection, and death, because physicians of the day were unaware that the regimens (8.0–31.2 g per day) produce levels associated with hyperventilation and pulmonary edema in 33% and 3% of recipients, respectively.

[0] https://academic.oup.com/cid/article/49/9/1405/301441

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#122

Post by InvaderFizz » Sun, Dec 12, 2021, 6:15 PM UTC

ogwh wrote: post #67

toomuchtodo wrote: post #31

Earlier quoted context omitted.

35. Perfect balance between maturity and youth.

Tell that to my hair follicles.

I started supplementing testosterone for reasons unrelated to hair loss. It has completely stopped and even reversed my thinning on top after just a few months.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#123

Post by aasasd » Sun, Dec 12, 2021, 6:15 PM UTC

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

I opened Wikipedia to see what you mean with the mention of the library, and there I read:

> Despite the widespread modern belief that the Library of Alexandria was burned once and cataclysmically destroyed, the Library actually declined gradually over the course of several centuries.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#124

Post by DeWilde » Sun, Dec 12, 2021, 6:17 PM UTC

eloff wrote: post #50

DeWilde wrote: post #36

Earlier quoted context omitted.

I have a rare condition related to insulin resistance and diabetes, blood sugar spikes greatly worsen my health. Discovered that vaccines spike sugar prety significantly after getting my two shots this year. Won't be getting boosters anytime soon as the side effects were gruesome.

My parents both reported consistent elevated blood sugar levels after getting the Pfizer vaccine. Not sure if it was related or just coincidence, but there seem numerous reports of the same online. It should be temporary though.

The immune response causes elevated blood sugar, among other things, for around 2 weeks.

For most people this is not really harmful but for people with blood glucose problems it can cause severe issues.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#125

Post by salehenrahman » Sun, Dec 12, 2021, 6:19 PM UTC

rp1 wrote: post #116

salehenrahman wrote: post #74

Earlier quoted context omitted.

Senescent cells themselves do not exist to prevent tumor growth. Cells becoming senescent is a mechanism that exists to prevent them from becoming a possible tumor, due to DNA damage. The problem with senescent cells is that accumulation of them results in tissues not functioning correctly. Eliminating them should make tissues function better. After all, your own immune system gets rid of senescent cell, but as we ag…

The paper says fisetin reduced the number of senescent cells in a sample. It’s not clear if that means the cells were eliminated or if the were prevented from entering a senescent state. Do you know the answer? The former sounds better than the later.

I have no idea.

All I can say is that the paper overwhelmingly uses the term "senolytic", which means to "kill off the senescent" (I'm assuming that it refers to senescent cells), as opposed to "senostatic", which means to "delay senescence".

Additionally, the concern brought up by the paper, is that senescent cells are known to be resistant against something called "apoptosis", which is a term to describe "programmed cell death". The goal of the paper is to explore a compound—fisetin—for its senolytic capabilities. Whether it is successful at finding that, I haven't fully read the paper to see if they have identified fisetin as a senolytic, or a senostatic agent.

With that said, however, some of the graphs in the paper does highlight that as fisetin dose increases, not only do senescent cells get depleted, but so do total number of cells. If we were working with a purely senostatic agent, relative to a control, the senescent cells would be much lower, but the overall cell count would be much higher, which is not the case with fisetin. Does this mean that fisetin is a senolytic? Maybe not; it could just indiscriminately target all cells, resulting in fewer cells. Or maybe it is. Who knows.

Or maybe my logic about cell counts regarding senostatic vs senolytic may be entirely wrong.

Whatever it is, I haven't read the whole paper.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#126

Post by derefr » Sun, Dec 12, 2021, 6:19 PM UTC

jws wrote: post #118

derefr wrote: post #113

Earlier quoted context omitted.

A few "yes, but..."s: > If you're not traveling outside the US and living a fairly normal life Globally, given an at-least-middle-class lifestyle (and any other years than 2020–2021), "not travelling outside [your home country]" is actually rather abnormal. It's mostly an American thing. I've seen it hypothesized that higher risk-aversion from a media-inculcated culture of fear could be responsible for Americans' uni…

MRI is much lower resolution than X-ray. Dental researchers are speculating about using MRI for some uses, like implant planning, but the laws of physics are not in favor of reducing the voxel size to match the small features identified with X-rays. My dentist just upgraded their gear, the tech no longer leaves the room when shooting the image, and I didn't get a lead blanket. Presumably that means the technology imp…

I don't know much about MRI technology, but would you get an improvement in resolution if the whole machine was scaled down (i.e. because it only needs to fit someone's head in it, rather than their whole body)?

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#127

Post by InvaderFizz » Sun, Dec 12, 2021, 6:20 PM UTC

clairity wrote: post #98

gremloni wrote: post #75

Earlier quoted context omitted.

Probably around 28 so I’m done growing to my final height.

observing professional sports, you find that despite physical fitness/attributes having already plateaued in the early-mid twenties, people reach peak athletic performance in our late twenties when our mental facilities have fully matured and we have some modicum of experience. 27-29 is probably exactly the maximizing range, for this reason.

I'm not sure allowing the beginning of deterioration that occurs after around 25 is a good thing in this scenario. The mental maturity is most likely largely a result of experience. I'm sure it has some hormonal impact, but that doesn't automatically mean late 20s is superior if we can maintain the healing capacity of a 18 year old while increasing our experience and therefore ability to process the whole picture.

I guess it comes down to: is the capacity of strategy developed as a result of age, or as a result of experience?

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#128

Post by dukeofdoom » Sun, Dec 12, 2021, 6:23 PM UTC

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

And yet you still won't be fully protected. Seems to me there's lots of vaxx regret from the double dosed, when they find out about omicron.

I'll check if you post in a few months. Otherwise, thank you for your contribution to science. In the mean time, don't recommend taking up competitive soccer.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#129

Post by JamesBarney » Sun, Dec 12, 2021, 6:24 PM UTC

ekianjo wrote: post #96

rmbyrro wrote: post #92

Earlier quoted context omitted.

I guess if it does NOT work on mice, it's highly unlikely to work on humans? In this case, it might be good predictor of failure, which can save a lot of money. Just speculating... Also, if something really bad goes on mice, we can avoid having that happening to humans. Which I would also value a lot. I mean, it seems to me experimenting on mice might be worth it.

> I guess if it does NOT work on mice, it's highly unlikely to work on humans? There is virtually no relationship whatsoever between what works in mice and humans. Such headlines are completely ridiculous by now: the track record of applicability is a train wreck.

This very much depends on the mouse model of disease. Obesity drugs for instance are highly predictive.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#130

Post by Jimmc414 » Sun, Dec 12, 2021, 6:25 PM UTC

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

Before signing up for this particular vaccine you might want to read up on what inhibition of antiapoptotic & apoptotic pathways means for your health.