71–80 of 382 posts
Earlier quoted context omitted.
So we should start with mould? What are you saying exactly? We have to start somewhere...
I just want the breathless headlines to include “in mice” (or appropriate animal) if it wasn’t in humans.
> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening. By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice. Mouse models of human disease are very limited in their predictive ability. Th…
Yes and this response has also become a trope. It’s generically universal to nearly any early result.
I've seen more comment section finger wagging in response to science articles, offering such wisdom as correlation isn't causation, XYZ "isn't a panacea", research into treatments to mitigate or avoid cancer "don't cure cancer", statistical confidence of 95% falls short of absolute proof, and any number of extraneous add-ons that make caricatures of the research and then bat those caricatures down.
It reminds me of this quip from the Onion, back in 2009:
"All that in just six years? Wow, that's so amazing. If you can't tell, I'm being sarcastic. And I'm being sarcastic because I don't understand the significance of the study."
Imagine the costs of a vaccine that would make you immortal in the US? Surely not everyone would be able to afford it. But then we could implement an immortality lottery, to give everyone a shot. That could be the devious slogan: “everyone gets a shot”. Devious because not everyone does, of course. If you win you get the vaccine and live forever, but your friends and family aren’t included.
Death represents a pretty serious destruction of human capital. If people will work forever, then why not let them live forever, much less retraining and less money spent on recruiting. This is only semi-sarcastic;)
Feel free to apply again next time Halley's comet is visible.
Fisetin is quite cheap and has been shown to eliminate senescent cells: https://pubmed.ncbi.nlm.nih.gov/30279143/
From reading that paper, the purpose of senescent cells is to prevent tumor growth. I don't know if I'd want to suppress or eliminate that functionality over a long period of time.
Cells becoming senescent is a mechanism that exists to prevent them from becoming a possible tumor, due to DNA damage.
The problem with senescent cells is that accumulation of them results in tissues not functioning correctly. Eliminating them should make tissues function better.
After all, your own immune system gets rid of senescent cell, but as we age, I believe your immune system is unable to keep up.
For the sake of discussion, which age would you want to pause at? 16, 24 for insurance reasons?
Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.
I’m with you. I’ve gotten vaccinated for everything my doctor lets me. Japanese Encephalitis? Pshaw. I don’t even know what it is, but good luck with my immune system. It’s like getting a superpower in a video game! And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga...
Infections can be the trigger for auto-immune diseases. We're not sure precisely how, but there seems to be a complex combination of genetic and environmental factors.
Your immune system is very much not playing games, it's in the business of reacting on a hair trigger, and doing more damage to foreign bodies than it does to your own body. It has an intricate system to avoid turning against yourself, but the system can fail.
If a B cell that produces auto-antibodies falls through the cracks, it will not die. You now have the problem of being in a permanent fight against your own immune system, with a variety of unfortunate results.
Now that's a lot of scary outcomes, and thankfully those diseases are uncommon. The system almost always works well. But it's a very complex system with ugly failure modes, so I wouldn't encourage you to poke the beast too much.
Imagine the costs of a vaccine that would make you immortal in the US? Surely not everyone would be able to afford it. But then we could implement an immortality lottery, to give everyone a shot. That could be the devious slogan: “everyone gets a shot”. Devious because not everyone does, of course. If you win you get the vaccine and live forever, but your friends and family aren’t included.
Earlier quoted context omitted.
Gotta admit though, there has never been a better time to be a mouse.
Really? Because they get experimented on and then slaughtered by the thousands
https://www.science.org/content/article/how-many-mice-and-ra...
For the sake of discussion, which age would you want to pause at? 16, 24 for insurance reasons?