For the sake of discussion, which age would you want to pause at? 16, 24 for insurance reasons?
35. Perfect balance between maturity and youth.
Japanese scientists develop vaccine to eliminate cells behind aging
31–40 of 382 posts
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#32> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening.
By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice.
Mouse models of human disease are very limited in their predictive ability. There's a lot of research that needs to follow this before there's even a hope of a human trial, let alone vaccine. And the failure rate for treatments at the mouse stage is quite high.
Some of the comments on this thread treat this research paper as the announcement of an an imminent anti-aging vaccine. It's not.
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#33Fisetin is quite cheap and has been shown to eliminate senescent cells: https://pubmed.ncbi.nlm.nih.gov/30279143/
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#34Fisetin is quite cheap and has been shown to eliminate senescent cells: https://pubmed.ncbi.nlm.nih.gov/30279143/
I tried fisetin once. No obvious effects (I am 43 only), save one: in the week afterwards, I lost about 4 pounds of weight effortlessly.
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#35Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.
That's tribal thinking, "us vs them". You want to spite "them", who ostensibly don't know a thing about vaccine, but you never bothered to learn it yourself
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#36Earlier quoted context omitted.
It's probably not a good idea to get every single vaccines that's not recommended to you by the CDC/your doctor. Vaccines could potentially trigger some dangerous side effects, however rare it is.
Vaccines are also, themselves, not exactly GOOD for you. They're just eliciting an immune response in order to obtain immunological defense at a theoretically/hopefully lower cost than the alternative infection. Subjecting yourself to immune response, which for some vaccines can have high amount of reactogenicity, is having your body undergo heavy inflammation, a fair amount of tissue damage, etc. The people that jus…
I have a rare condition related to insulin resistance and diabetes, blood sugar spikes greatly worsen my health.
Discovered that vaccines spike sugar prety significantly after getting my two shots this year. Won't be getting boosters anytime soon as the side effects were gruesome.
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#37Fisetin is quite cheap and has been shown to eliminate senescent cells: https://pubmed.ncbi.nlm.nih.gov/30279143/
I tried fisetin once. No obvious effects (I am 43 only), save one: in the week afterwards, I lost about 4 pounds of weight effortlessly.
I don’t recommend this, nor have I tried it: Some people experiment with high doses, like 1-2g, within one day, twice a week. Anecdotal reports of scars fading, but also scary effects like hypocoagulation (won’t stop bleeding). Just internet rumors though, I‘d wait for clinical studies.
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#38Earlier quoted context omitted.
It's probably not a good idea to get every single vaccines that's not recommended to you by the CDC/your doctor. Vaccines could potentially trigger some dangerous side effects, however rare it is.
don't drive cars, they can crash and it can be fatal while having other side effects, however rare they are.
I agree with that statement (not sarcastic)
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#39> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening. By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice. Mouse models of human disease are very limited in their predictive ability. Th…
There are many imminent aging therapies in clinical trials though or upcoming. Not saying it will reverse it but it may slow it down and compress the morbidity period. Such therapies include the promising Mayo Clinic trial on using large doses of Fisetin to get rid of senescent cells, or similarly Dasatnib + Quercetin, gene therapy like PGC-1a for maintaining muscle mass in older age, epigenetic reprogramming, mTOR inhibitors like Sirolimus or other rapalogues, etc.
So it’s very likely that some of the advances we see today that are still in clinical stage will hit the market in 5 to 15 years.
Edit: typo
Re: Japanese scientists develop vaccine to eliminate cells behind aging
#40What does HN think of the actual science behind this?
To not answer your question, here's the /r/science thread https://www.reddit.com/r/science/comments/ren6cc/japanese_sc...
The title on that Reddit post is far better than the one on this post. It'd be nice if Hacker News would increase their title length limit.