41–50 of 127 posts
Earlier quoted context omitted.
One way to do this — and I don’t know why it isn’t done — is to use a general anesthetic and then administer drug/placebo and record effects.
Not clear that it works when not conscious
Psilocybin + anesthetic
Psilocybin + nothing
Control + anesthetic
Control + nothing
For me, I get depressed when I feel "stuck" in my circumstances (mostly a directionless project, bad boss, or cancerous working environment, or all of the above). I suppose going on a "trip" would alleviate that significantly, at least for a while. Then you'll get used to it and you'll be back to square one you can't escape without fixing the root cause. So any enthusiasm for this is going to have to be tempered by l…
Ketamine also. It's already approved. I would prefer all drugs were legalized as in Portugal and regulated because it's impossible for a consumer of illicit drugs to verify their contents and it would cut off criminal profiteering, violence, and the police-prison-industrial-complex from some funding too.
Trafficking is still a criminal offence, and personal possession is still punishable with a fine.
Psilocybin has changed my life. It needs to be available to everyone in the world. Pharmaceutical companies will fuck it up (it's coming - very quickly) so learn to grow your own.
Legality aside, growing and consuming a fungus to me, someone who knows nothing about them outside the grocery store, sounds very dangerous.
Some quick points: > 233 patients Very small, can't generalize results based on such a small number. Doesn't mean the study's trash or anything, but don't jump to any conclusions here - good or bad. > "The trial, which had all patients stopping antidepressants before participating, compared two active doses of COMP360, 25mg and 10mg, against a comparator 1mg dose." - COMP360 was, I assume, their therapeutic psilocybi…
From the topline data [1]:
- 3 Suicidal behaviour
- 5 Self-injury
- 4 Suicidal ideation
- 1 Drug withdrawal (from codeine?)
- 1 Adjustment disorder with anxiety
- 1 Adjustment disorder with mixed anxiety and depressed mood
- 1 Hospitalisation
[1] https://compasspathways.com/knowledge-navigator/pdf/COMP001%...
Earlier quoted context omitted.
9 weeks of TMS should be tried before ECT. ECT is just one away from a lobotomy in terms of brutality and risk.
ECT is not as brutal or risky as it used to be. You can now opt for unilateral treatment (only shocking one hemisphere) rather than bilateral for the same outcome with lessened side effects. I agree TMS should come first, but I think the comparison of ECT to lobotomy is misguided.
Ketamine also. It's already approved. I would prefer all drugs were legalized as in Portugal and regulated because it's impossible for a consumer of illicit drugs to verify their contents and it would cut off criminal profiteering, violence, and the police-prison-industrial-complex from some funding too.
Drugs are not legalised in Portugal, they're decriminalised. Trafficking is still a criminal offence, and personal possession is still punishable with a fine.
Headline could be more informative by including this number.
29.1% effective Headline could be more informative by including this number.
29.1% effective Headline could be more informative by including this number.
"Overall, 29.1% of patients in the highest-dose group were in remission three weeks after treatment, compared to 7.6% of those in the control group, "