Psilocybin has changed my life. It needs to be available to everyone in the world. Pharmaceutical companies will fuck it up (it's coming - very quickly) so learn to grow your own.
Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
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Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#22Psilocybin has changed my life. It needs to be available to everyone in the world. Pharmaceutical companies will fuck it up (it's coming - very quickly) so learn to grow your own.
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Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#23Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#24Earlier quoted context omitted.
To someone who has done mushrooms before, sure, they can tell. But for people with no psychedelic experience, niacin (a common stand-in) causes flushing and some other effects which a patient can tell "is doing something." IIRC, the famous "Good Friday" psilocybin experiment had some people from the control group believe they were not in the control group.
> IIRC, the famous "Good Friday" psilocybin experiment had some people from the control group believe they were not in the control group. I can find a few people right now that believe that Lord of the Rings is a historical account of medieval Europe.
Right but when it comes to questions of placebo, the belief is what matters.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#25I’m a believer in the potential value but think placebo or blind studies of psychedelics are absurd. You know full well of you’ve eaten an eighth of cubensis. I think to be fair, they should compare psychedelic treatment to other therapies like ECT or a weeklong vacation to Hawaii.
9 weeks of TMS should be tried before ECT. ECT is just one away from a lobotomy in terms of brutality and risk.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#26Ketamine also. It's already approved.
I would prefer all drugs were legalized as in Portugal and regulated because it's impossible for a consumer of illicit drugs to verify their contents and it would cut off criminal profiteering, violence, and the police-prison-industrial-complex from some funding too.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#27The trial tested psilocybin combined with therapy. This isn’t equivalent to ad-hoc self treatment with mushrooms. They noticed a response to psilocybin+therapy in about 20-25% of patients depending on the criteria for “sustained response”: > The protocol-defined sustained response* up to week 12 was double, with 20.3% of patients in the 25mg group It’s also notable that about 5% of the psilocybin receivers experience…
This sounds pretty crappy right? If I'm understanding the numbers, 25% response is about like what we get with a placebo in most studies if my memory is correct. It sounds like they were tripping balls on 25 mg, so this is definitely in active placebo range. From my memory: Placebo is about 25%. Antidepressants about 35% response rate. Active placebo of something like atropine which makes you feel weird but isn't an…
I’m not sure if it makes a difference, but this study was conducted on _treatment resistant_ patients.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#28I’m a believer in the potential value but think placebo or blind studies of psychedelics are absurd. You know full well of you’ve eaten an eighth of cubensis. I think to be fair, they should compare psychedelic treatment to other therapies like ECT or a weeklong vacation to Hawaii.
This does at least show a difference between 10 mg and 25 mg dosage.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#29The thing that's not clear is, how often do you have to do this? It's definitely not an everyday pill like Prozac, but it's not very effective after 6 weeks. Would you trip every 2 months? Seems like that would rapidly run into diminishing returns. No one has even tested a second dose! How is this actually going to work?
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#30Psilocybin has changed my life. It needs to be available to everyone in the world. Pharmaceutical companies will fuck it up (it's coming - very quickly) so learn to grow your own.
Legality aside, growing and consuming a fungus to me, someone who knows nothing about them outside the grocery store, sounds very dangerous.