Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

The main thing about Phenylacetone meth is that there's so much of it

dynomight.net

Post reply on HN
Print view View original

241–250 of 371 posts

Re: The main thing about Phenylacetone meth is that there's so much of it

#241

Post by jkhdigital »

throwaway2331 wrote: post #80
wswope wrote: post #34

Earlier quoted context omitted.

Great writeup! Just adding on: Other key differentiator between recreational and therapeutic amphetamine usage is the pharmacokinetics: Vyvanse is the best in this regard - it’s actually an amphetamine prodrug that gets converted to amphetamine in the bloodstream over the course of ~2 hours, giving a very smooth release. Adderall achieves a similar end (to a lesser degree) by combining equal ratios of four different…

Adding on: the problem with vyvanse is that there's no way to mess around with the dosage to get it "just right." It's like a more strict version of extended release (EX) and timed release formulations (there's a difference!). Vyvanse is metabolized to d-amphetamine in your blood cells (the specific mechanism escapes me right now), unlike the regular non-prodrug versions which get "metabolized" first in your stomach…

I’ve been on Vyvanse for a couple years now, and while I was titrating up the dosage I got into the habit of “spreading out” the capsule by opening it up and taking half about three hours apart. The idea was to make sure that the peak effect occurred at the right time. I recently discovered that this probably served no purpose whatsoever, and taking the entire pill at once produces pretty much the exact same overall effect profile.

Re: The main thing about Phenylacetone meth is that there's so much of it

#242

Post by lotophage »

dcolkitt wrote: post #88
dynm wrote: post #2

Around a week ago, I came across this link here on HN that suggested that there's a new form of meth: https://news.ycombinator.com/item?id=28938888 The theory is that new meth is based on a synthesis using a chemical called P2P rather than the old synthesis that used ephedrine. There are claims that this new form of meth is chemically different in some what that started creating schizophrenia around 2017. However, wh…

Much of the effects of any intoxicant are culturally constructed. Alcohol is widely known for causing aggression, but this effect doesn’t seem to exist in cultures without that association. Nor does it exist in double-blind studies, yet the placebo group becomes more aggressive. You can start with two chemically identical intoxicants, and either by marketing or random path dependencies one gains a reputation in the s…

> One theory is that much of the meth contains residue of toxic chemicals used in its production, or other contaminants. Even traces of certain chemicals, in a relatively pure drug, might be devastating. The sheer number of users is up, too, and the abundance and low price of P2P meth may enable more continual use among them. That, combined with the drug’s potency today, might accelerate the mental deterioration that ephedrine-based meth can also produce, though usually over a period of months or years, not weeks.

These are the theories mentioned in the article referenced in the comment you replied to. It might be the meth itself. Gin, whiskey, and tequila are different colors, and it's not because they are compositionally identical.

Re: The main thing about Phenylacetone meth is that there's so much of it

#243

Post by chucksta »

daveguy wrote: post #210
rsj_hn wrote: post #206

Earlier quoted context omitted.

But the harm or benefit of a policy is not measured by how many specific decisions are performed, but rather by the overall effect of the policy on the community, no? So let's just talk about that rather than counting steps between A and B.

The overall harm or benefit to the community is certainly related to how many and likely those bad decisions are that result in a specific harm/benefit.

Something like this? https://www.vox.com/2014/5/19/5727712/drug-alcohol-deaths

Re: The main thing about Phenylacetone meth is that there's so much of it

#244

Post by pinewurst »

adolph wrote: post #72
kens wrote: post #64

The article mentions the ban in 2006 of over-the-counter sales of Sudafed (pseudoephedrine). One of my favorite satirical articles is "A simple and convenient synthesis of pseudoephedrine from N-methylamphetamine". (The joke being that Sudafed is now hard to purchase while meth is readily available.) https://www.improbable.com/airchives/paperair/volume19/v19i3...

In the below podcast an author of a book about recent meth developments talks about the ban of Sudafed entirely in Mexico lead to a change in the market toward fentanyl. Author and journalist Sam Quinones talks about his book, The Least of Us, with EconTalk host Russ Roberts. Quinones focuses on the devastation caused by methamphetamine and fentanyl, the latest evolution of innovation in the supply of mind-altering d…

This book was abstracted into a great Atlantic article mentioned at the beginning of the original post.

https://www.theatlantic.com/magazine/archive/2021/11/the-new...

Re: The main thing about Phenylacetone meth is that there's so much of it

#245

Post by version_five »

m0zg wrote: post #222
perardi wrote: post #130

Bit of a tangential rant: meth is actually truly really bad, and I wish our drug education growing up hadn’t painted this nebulous concept of “drugs”, because there’s gradations of harm. I’m approaching 40. (Ugh, I hate to admit that.) I grew up during the D.A.R.E. era. Just Say No. Cartoon All-Stars to the Rescue. “Drugs” were this boogeyman, and whatever they were, they would turn you into a junkie instantly. I hav…

> with the exception of meth and opiates That's like saying "I did a lot of drugs, except the ones that _really_ fuck you up". 100K people will die in the US this year from hard drug overdoses. 93K died last year. This also ignores the fact that several times the number are circling down the societal shitter due to their addiction. That's not to disagree that e.g. MJ is less dangerous than alcohol when consumed in mo…

> heroin and meth should be legal, and freely available, and they will read your comment with that bias in mind. I'd much rather have the old DARE bullshit than allow this to happen.

Why? Do you think somehow things would be worse with legal, controlled drugs?

Re: The main thing about Phenylacetone meth is that there's so much of it

#246

Post by grepfru_it »

mjevans wrote: post #237
xyzzyz wrote: post #227

Earlier quoted context omitted.

Teachers and parents can get vaccinated themselves, no? I thought the vaccine works, doesn’t it?

The Alpha variant of COVID-19 was strongly suppressed by the vaccines that were approved in the US, and also the others globally. Since around early Summer Delta has been the dominant variant, which is extremely more transmissible. Even if vaccinated, Delta still retains effective transmutability, though (maybe?) to a reduced degree even for fully vaccinated individuals. Since we still don't have sufficient tests to…

last i read kids (~7 and under) didn't have "fully developed ACE2 receptors" which lead to the spike RBD not fully binding in young children. this allowed their immune system to fight the invader and gave them very strong protection against SARS-CoV-2.

mutations could bring about a spanish-flu style pandemic in the young so i agree it's not a good time to get comfortable yet.. but i'm not sure i agree with mRNA vaccines being forced on all (especially kids) without long term study data. especially when subunit and inactivated vaccines for the S1 protein now exist

Re: The main thing about Phenylacetone meth is that there's so much of it

#247

Post by chucksta »

xyzzyz wrote: post #194
mjevans wrote: post #180

Earlier quoted context omitted.

If only they'd legalize, tax, and regulate the meth... We could get our real cold symptom treatments back as true OTCs and stop wasting so much time chasing petty criminals. It would also help identify drug addicts and get them help before problems become bad.

If they did that, the consumption would only go up, resulting in even more overdoses. That’s what happened in Portugal, after drug decriminalization — drug consumption there went up significantly (with exception of heroin, which went down, but it also went down in other European countries at the same time which did not decriminalize it). Full on legalization will increase consumption even higher. Of course, one might…

Meth was legal until the 70s, society functioned. The current problem is another side effect of the war on drugs

https://www.history.com/topics/crime/history-of-meth

Re: The main thing about Phenylacetone meth is that there's so much of it

#248

Post by throwaway2331 »

stainforth wrote: post #233
throwaway2331 wrote: post #189

Earlier quoted context omitted.

Apologies; I confused BPC-157 with TB-500, and made a horrible amalgamation. What do you want to know? Do you have some specific goal you want achieved or curiosity that you would like satisfied? It's been a bit since I've been involved with these things. Most of it is underground, but I can give you a quick rundown. BPC-157 and TB-500 are regenerative peptides. BPC-157 seems to be more "global" and neuro-involved th…

Looks like there's NASA sold in spray form, how would that compare in efficacy to subcutaneous injection?

Seems to act differently depending on route of administration. If you've ever had weed, it's like edibles (injecting) vs. smoking (nasal).

Intranasal is more cerebral, "in your head" type of effects.

Subq is more bodily, "all around your body" type of effects.

If you're looking at it as a nootropic, I would recommend the spray. It feels similar to prozac and wellbutrin, if they weren't so terrible.

If you're looking at is as an anodyne or body-anxiolytic, I would recommend subq. If feels like baclofen.

Re: The main thing about Phenylacetone meth is that there's so much of it

#249

Post by chucksta »

perardi wrote: post #130

Bit of a tangential rant: meth is actually truly really bad, and I wish our drug education growing up hadn’t painted this nebulous concept of “drugs”, because there’s gradations of harm. I’m approaching 40. (Ugh, I hate to admit that.) I grew up during the D.A.R.E. era. Just Say No. Cartoon All-Stars to the Rescue. “Drugs” were this boogeyman, and whatever they were, they would turn you into a junkie instantly. I hav…

Meth was legal until the 70s, society functioned. The current problem is another side effect of the war on drugs

https://www.history.com/topics/crime/history-of-meth

Re: The main thing about Phenylacetone meth is that there's so much of it

#250

Post by [deleted] »

lotophage wrote: post #242
dcolkitt wrote: post #88

Earlier quoted context omitted.

Much of the effects of any intoxicant are culturally constructed. Alcohol is widely known for causing aggression, but this effect doesn’t seem to exist in cultures without that association. Nor does it exist in double-blind studies, yet the placebo group becomes more aggressive. You can start with two chemically identical intoxicants, and either by marketing or random path dependencies one gains a reputation in the s…

> One theory is that much of the meth contains residue of toxic chemicals used in its production, or other contaminants. Even traces of certain chemicals, in a relatively pure drug, might be devastating. The sheer number of users is up, too, and the abundance and low price of P2P meth may enable more continual use among them. That, combined with the drug’s potency today, might accelerate the mental deterioration that…

[deleted]
Post reply on HN