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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#71

Post by inglor_cz »

d4rkp4ttern wrote: post #60
mantas wrote: post #21

Earlier quoted context omitted.

It's super easy to treat if caught early. But that's where the good ends. Vast majority of cases present the infamous circle. But some don't. And if you got the circle in a hard-to-notice spot, it's easy to miss it (it will a month or two into infection) too. First precaution is to check your legs (and possibly torso/hands) for ticks after passing through high grass. And whole body after coming from the woods. The na…

Should we assume we are safe if we go hiking in a place where we never brushed against any plants or grass or twigs? In other words we went through woods but only stayed on wide open trails. I assume ticks don’t “fly” in the air ?

Ticks don't fly and they generally dislike sunlit or dry places. They will mostly lurk in darker, wetter places, up to 3 feet from the ground. So a shady tree patch with overgrown grass at the edge of a swamp or creek is much more likely to be thoroughly infested than other places.

Use a repelent, wear some light-colored clothes to spot a crawling tick easily, tuck the (long!) trousers into your hiking shoes and you should be OK.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#73

Post by lampe3 »

ianhawes wrote: post #25
_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

The biggest investment that Pfizer made was the creation of a way to reliably manufacture mRNA vaccines. Now they must recoup those investments.

Can you name any big company that does not work that way? Like Apple, Facebook, Ford, Tesla, Nestle ect ect.

And what would be an alternative?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#74

Post by inglor_cz »

kingkawn wrote: post #58
inglor_cz wrote: post #48

Earlier quoted context omitted.

Because it means rerunning the trials again. These requirements will have to be loosened for anti-Covid vaccines. They are tailored to other diseases, but SARS-CoV-2 mutates too fast. The flu vaccine has an exception, too, otherwise it wouldn't be possible to prepare the correct vaccine (against the expected dominant strain) on time.

One bad autoimmune reaction from a poorly engineered vaccine and the whole society will boycott the mRNA vaccines forever after. Safety is higher priority to ongoing viability than speed.

Safety and speed must usually be balanced in a trade-off, and we are actually used to it, that is why people drive a car, even though it comes with a risk of dying or being maimed.

I have no doubt that some kind of safety-related trials must be run on boosters and that they will be run, but they will likely only take weeks in the future, not months.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#75

Post by twooster »

foolinaround wrote: post #36
Thaxll wrote: post #7

Why is it a vaccine? Are there going to be vaccine for everything in the future?

Should we have a vaccine for addictions? alcoholism? drug use? eating? Eg: Give it early in people's lives, that the first time they drink even a little alcohol, it should produce such (non life threatening) symptoms - terrible taste, throw up etc, they would not touch it again, and therefore won't be addicted?

It's been done: https://en.wikipedia.org/wiki/Disulfiram

Not as a vaccine, but as a drug.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#77

Post by _Microft »

timonoko wrote: post #50

Emphasis should be on tick-bite prevention. I have never had live tick on me and have been literally wallowing on all tick-infested areas of northern hemisphere. They just die. Most probably just drop off, but sometimes there is dead tick only slightly attached. Looks like they die on first drop of blood.

People developing immunity to ticks has been reported. We discussed that here half a week ago: https://news.ycombinator.com/item?id=28281523

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#79

Post by walidwalid »

jhrmnn wrote: post #67
pibechorro wrote: post #42

Earlier quoted context omitted.

We should not call them vaccines, they work totally different. These are gene treatments.

Absolutely not correct. They do work exactly like conventional vector vaccines, the only difference is how the genetic material of the foreign virus is delivered to the cells of the patient. The genetic material of the patient (the genes) is not modified.

Can you guarantee that and sign with your own blood ?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#80

Post by Ovah »

jhrmnn wrote: post #67
pibechorro wrote: post #42

Earlier quoted context omitted.

We should not call them vaccines, they work totally different. These are gene treatments.

Absolutely not correct. They do work exactly like conventional vector vaccines, the only difference is how the genetic material of the foreign virus is delivered to the cells of the patient. The genetic material of the patient (the genes) is not modified.

Technically speaking ... the genetic code of the B cell receptor gene of B cells is altered by vaccines. The same goes for pretty much all antigens the body comes across. But that's the point of the adaptive immune system and is obviously not what OP meant. https://en.wikipedia.org/wiki/V(D)J_recombination
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