This is Phase 2, but I wonder how long Phase 3 will take, given that getting Lyme disease is still pretty rare, can easily be missed or misdiagnosed, it will takes a lot of time and people to get a significant effect between a control group and vaccinated people
Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
61–70 of 271 posts
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#62I actually had Lyme disease when i was younger. Curiously enough, i didn't get the somewhat common rash after the tick bite, but instead it was discovered later, as a part of blood testing. I was submitted to that after my relatives had concerns about how lethargic i was being, as well as because i was experiencing joint pain, which the blood test later seemed to confirm.
If i recall correctly, i was given antibiotics and felt pretty bad for a month onwards, though nowadays i'm not aware of any lingering long term effects, apart from maybe my short term memory being slightly worse than i'd expect it to. Of course, i think that in my case i had it pretty easy, since some other folks are known to develop symptoms that are considerably more worse. Whether there will be any lingering consequences in my future because of it, only time will tell.
A vaccine would definitely be welcome, especially because of how common ticks are here in Eastern Europe - any walk in the forest might end with more than one of them on your clothes. If you have dogs, you'll probably have to remove dozens of those from their fur every summer.
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#63Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…
The biggest investment that Pfizer made was the creation of a way to reliably manufacture mRNA vaccines. Now they must recoup those investments.
I think the term you're looking for is capitalize. Pfizer made some investments in a technology that had wide applications, and now they want to capitalize on it. It's good business, and a lot of people are going to be helped in the process.
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#64This is Phase 2, but I wonder how long Phase 3 will take, given that getting Lyme disease is still pretty rare, can easily be missed or misdiagnosed, it will takes a lot of time and people to get a significant effect between a control group and vaccinated people
Lyme is not rare, the CDC estimates 476,000 cases per year in the US. https://www.cdc.gov/lyme/stats/humancases.html
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#65I love Pfizer. They censor the entire internet and fuck up the world.
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#66Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#67Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…
We should not call them vaccines, they work totally different. These are gene treatments.
Absolutely not correct. They do work exactly like conventional vector vaccines, the only difference is how the genetic material of the foreign virus is delivered to the cells of the patient. The genetic material of the patient (the genes) is not modified.
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#68Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…
HIV was a few days ago. Amazing if it works. https://gizmodo.com/moderna-set-to-test-experimental-hiv-mrn...
BioNTech is working on a malaria vaccine as well. If this one works out well, it would be a huge win for all mankind.
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#69Finally, I can be as protected as my dog!
Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
#70The first vaccine had a problem where it gave people Lyme every once in a while. My hypothesis is that Lyme disease is an autoimmune disease caused by being exposed too acutely in some way, or for too long. For some people, a tick byte isn’t enough exposure to trigger it. For others, the vaccine is enough. They didn’t catch it early in clinical trials because those people are rare enough to not show up in small studi…
> The first vaccine had a problem where it gave people Lyme every once in a while. Do you have a citation for that? The FDA review didn’t mention that: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/
> 59 reports of arthritis associated with vaccination
Maybe it was coincidence. I’m just saying if the vaccine gave people Lyme, here’s my hypothesis. But it makes a lot of sense that an autoimmune disease created by exposure to X could be triggered by a vaccine containing X. The definition of a vaccine is to expose a person to whatever it is the immune system recognizes — spike proteins and so on. It’s plausible. But as you point out, not very likely.