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Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

cell.com

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Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#71

Post by anonuser123456 »

mbgerring wrote: post #67
ClumsyPilot wrote: post #62

Earlier quoted context omitted.

Well unfortunately COVID forgot to ask my opinion before gifting me with one for free

I’m sorry you got sick, and I’m glad to see this study suggesting you have durable immunity! I worry that since it’s dated July 14 it may not have enough data on the Delta variant to be useful in considering your risk going forward. I hope you remain in good health.

The immunity acquired from infection may be more robust against variants since a broader set of antibodies are produced.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#73

Post by tchalla »

wizzwizz4 wrote: post #63
slumpt_ wrote: post #53

Earlier quoted context omitted.

Vaccination also has more durable immunity than natural immunity in this case. Without those risks you outline.

I expected this for the mRNA vaccine, but source?

> Now, a new NIH-supported study shows that the answer to this question will vary based on how an individual’s antibodies against SARS-CoV-2 were generated: over the course of a naturally acquired infection or from a COVID-19 vaccine. The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single letter” changes in a key portion of their spike protein compared to antibodies acquired from an infection.

https://directorsblog.nih.gov/2021/06/22/how-immunity-genera...

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#74

Post by Valgrim »

nickthemagicman wrote: post #9
hprotagonist wrote: post #6

https://www.nature.com/articles/s41586-021-03738-2 vaccines also produce durable and persistent immune responses. Primary antibody titers wane, but the system itself remembers and can regenerate them when challenged. see https://news.ycombinator.com/item?id=28107714 for contra "but muh boosters", which i suspect is what's helping me collect downvotes.

Natural immunity may work better considering the vaccine requires booster shots every 12 months according to the Pfizer CEO. https://www.cnbc.com/2021/04/15/pfizer-ceo-says-third-covid-...

The requirement for booster shots may be for increasing immunity to variants, not the original virus. If you survived the original virus and got an immunity out of it you are just as vulnerable to variants as anyone who got the vaccine.

Basically, subsequent shots are security updates.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#75

Post by plorg »

briefcomment wrote: post #56
mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

That's a strawman. Can you instead address this particular bucket: people who have had Covid, and are now wondering if they are as immune as they can hope for, considering all other available interventions.

I absolutely don't think it's a strawman. Nearly to a person, the people in my life who have not gotten vaccinated and have not yet gotten Covid-19, if asked, have been making this argument: it's not that bad, it's not worth getting the vaccine.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#76

Post by ramraj07 »

briefcomment wrote: post #56
mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

That's a strawman. Can you instead address this particular bucket: people who have had Covid, and are now wondering if they are as immune as they can hope for, considering all other available interventions.

Actually being infected with Covid (symptomatic) probably does confer the best immunity possible, for sure. You should still get vaccinated after that though, because research suggests that vaccination can significantly help alleviate long COViD symptoms which a large fraction of patients have. Haven’t seen actual numbers on the immunity boost conferred by post-Covid vaccination though (no reason to think it’ll not add at least a slight bit).

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#77

Post by peteradio »

raphlinus wrote: post #55
015a wrote: post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

I know this thread is catnip for the antivax contingent that reliably appears, but this argument has several problems. First, our vaccines provide a stronger immune response than infection, as has been well documented by now[1]. Vaccination on top of prior infection boosts the response[2]. Second, the harm from the vaccine is minimal, and comparing it with an amputation is ridiculous (in spite of the large number of…

[1] is not generally supportive of your very broad statement. You must qualify you statement with some indication of this stated limitation: "carrying “single letter” changes in a key portion of their spike protein"

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#78

Post by tchalla »

anonuser123456 wrote: post #71
mbgerring wrote: post #67

Earlier quoted context omitted.

I’m sorry you got sick, and I’m glad to see this study suggesting you have durable immunity! I worry that since it’s dated July 14 it may not have enough data on the Delta variant to be useful in considering your risk going forward. I hope you remain in good health.

The immunity acquired from infection may be more robust against variants since a broader set of antibodies are produced.

May be not.

> The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single letter” changes in a key portion of their spike protein compared to antibodies acquired from an infection.

https://directorsblog.nih.gov/2021/06/22/how-immunity-genera...

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#79

Post by Buttons840 »

nickthemagicman wrote: post #41
ajross wrote: post #15

Earlier quoted context omitted.

Vaccine immunity IS "natural" immunity. It works the same way, by exposing the body's immune system to virus components such that they product a response. The only difference is that with a vaccine those components don't add up to a viable organism. But yes: expect newer vaccines tailored to currently-circulating strains to appear; the existing mRNA vaccines produce copies of the spike protein sequenced more than a y…

How is an mRNA strand that encode for a single very specific protein on a virus the same as the entire virus? The antibody memory made from a Natural Infection seems like it would be much richer and have much more variety than the mRNA vaccine. I would imagine the attenuated virus vaccine would be closer to Natural immunity.

Your body might accidentally create an immunity to a portion of the virus that mutates. Perhaps the protein produced by vaccine mRNA forces your body to create an immunity against a portion of the virus that is less likely to mutate.

I don't know if this is the case, but I offer this as an example of how our biological systems may be complicated beyond intuition.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#80

Post by anonuser123456 »

slumpt_ wrote: post #53
mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

Vaccination also has more durable immunity than natural immunity in this case. Without those risks you outline.

I’m not sure this is clear. Yes, this is what has been stated in the media, but I have yet to see data to back the claim.

And in particular it has been shown that natural immunity produces a much broader set of antibodies that may allow the immune system to cope with variants better.

I’m not advocating natural immunity btw. I completely agree people should get the vaccine.

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