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Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

cell.com

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Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#61

Post by lazyjones »

mercora wrote: post #37
015a wrote: post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

how easy is it to test for these antibodies for a layman? could people actually easily get tested prior to considering a vaccination?

There are commercially available antibody tests that can distinguish between antibodies from natural infection and from the common vaccines.

https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/anti...

>The first vaccines distributed in the United States induce antibodies to S protein. Thus, presence of antibodies to N protein indicates previous natural infection regardless of vaccination status, while presence of antibodies to S protein indicates either previous natural infection or vaccination.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#62

Post by ClumsyPilot »

mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

Well unfortunately COVID forgot to ask my opinion before gifting me with one for free

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#63

Post by wizzwizz4 »

slumpt_ wrote: post #53
mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

Vaccination also has more durable immunity than natural immunity in this case. Without those risks you outline.

I expected this for the mRNA vaccine, but source?

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#64

Post by SideburnsOfDoom »

briefcomment wrote: post #56
mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

That's a strawman. Can you instead address this particular bucket: people who have had Covid, and are now wondering if they are as immune as they can hope for, considering all other available interventions.

> people who have had Covid, and are now wondering if they are as immune as they can hope for, considering all other available interventions.

They are not "as immune as they can hope for" and would benefit from vaccination, after having had COVID, in that respect.

Links posted already, but mainly https://www.healthline.com/health-news/why-you-need-to-get-v...

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#65

Post by rvp-x »

015a wrote: post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

I am under the impression that a lot of places consider recovered cases as equivalent to fully vaccinated.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#66

Post by [deleted] »

slumpt_ wrote: post #53
mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

Vaccination also has more durable immunity than natural immunity in this case. Without those risks you outline.

[deleted]

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#67

Post by mbgerring »

ClumsyPilot wrote: post #62
mbgerring wrote: post #47

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

Well unfortunately COVID forgot to ask my opinion before gifting me with one for free

I’m sorry you got sick, and I’m glad to see this study suggesting you have durable immunity! I worry that since it’s dated July 14 it may not have enough data on the Delta variant to be useful in considering your risk going forward. I hope you remain in good health.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#68

Post by Valgrim »

orbifold wrote: post #27
hprotagonist wrote: post #6

https://www.nature.com/articles/s41586-021-03738-2 vaccines also produce durable and persistent immune responses. Primary antibody titers wane, but the system itself remembers and can regenerate them when challenged. see https://news.ycombinator.com/item?id=28107714 for contra "but muh boosters", which i suspect is what's helping me collect downvotes.

Not really the anti-body count decays more quickly compared to that of a natural infection and does so dramatically especially for older people: https://www.thelancet.com/journals/lancet/article/PIIS0140-6... . This is the underlying reason that there is talk of boosters.

It is normal for antibodies to decline after an immune response, it doesn't mean the immunity is gone, the immune system remembers how to produce them when needed.

The paper you link actually says that the memory B-cell populations appear to be maintained after the waning of the antibodies. B-cells are the cells that remembers and creates antibodies in response to an antigen (like the spike protein on the surface of the virus).

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#69

Post by dang »

All: I know it's an activating topic, but this thread has tons of comments breaking the site guidelines. That's not ok.

If you're going to comment, make sure you know the rules and stick to them: https://news.ycombinator.com/newsguidelines.html. That means making substantive points thoughtfully.

If you want to put down or yell at people on the other side of this $hot-topic, or any topic, please do that somewhere else. We're trying for a little better than internet default here.

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