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Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

cell.com

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Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#51
post #31

Immunity persists for a while but doesn’t seem to stop the new variants. Another study shows that re-infection with Covid is a lot more likely in unvaccinated people than in vaccinated.

Do you or anyone else have a link to the other study?

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#52
post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

I had covid in November. Have had it again the past week and a half. It was a rough time the first time, but not as bad as when I had pneumonia.

Now, A constant mild sore throat and a lot of bad headaches. Otherwise not much.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#53

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

Vaccination also has more durable immunity than natural immunity in this case. Without those risks you outline.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#54
post #15
post #2

Can any of the findings from the properties of how natural immunity works be guided in to future COVID 19 vaccines? Given how the pharma companies are examining anti-body half life, exploring booster shots, and considering vaccinations against variants (like lambda), can any of the learnings go into a more durable, more broad vaccine?

Vaccine immunity IS "natural" immunity. It works the same way, by exposing the body's immune system to virus components such that they product a response. The only difference is that with a vaccine those components don't add up to a viable organism. But yes: expect newer vaccines tailored to currently-circulating strains to appear; the existing mRNA vaccines produce copies of the spike protein sequenced more than a y…

The Red Cross disagrees[1]: “One of the Red Cross requirements for plasma from routine blood and platelet donations that test positive for high-levels of antibodies to be used as convalescent plasma is that it must be from a donor that has not received a COVID-19 vaccine. This is to ensure that antibodies collected from donors have sufficient antibodies directly related to their immune response to a COVID-19 infection and not just the vaccine, as antibodies from an infection and antibodies from a vaccine are not the same.”

Interestingly this means if you have natural immunity and are a regular blood donor you shouldn’t get the vaccine since it deprives the healthcare system of a lifesaving treatment.

[1] https://www.redcrossblood.org/donate-blood/dlp/coronavirus--...

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#55
post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

I know this thread is catnip for the antivax contingent that reliably appears, but this argument has several problems.

First, our vaccines provide a stronger immune response than infection, as has been well documented by now[1]. Vaccination on top of prior infection boosts the response[2].

Second, the harm from the vaccine is minimal, and comparing it with an amputation is ridiculous (in spite of the large number of superstitious people who believe otherwise).

There are subtle arguments to be made for adjusting vaccination (one shot is almost certainly enough) when prior infection is documented, but from a public health perspective it's simple enough: pretty much everybody (over 12 until trials complete) should get vaccinated, and if they did, illness and death would decrease dramatically.

[1]: https://directorsblog.nih.gov/2021/06/22/how-immunity-genera...

[2]: https://jamanetwork.com/journals/jama/fullarticle/2782139

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#56

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

That's a strawman. Can you instead address this particular bucket: people who have had Covid, and are now wondering if they are as immune as they can hope for, considering all other available interventions.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#57
post #31

Immunity persists for a while but doesn’t seem to stop the new variants. Another study shows that re-infection with Covid is a lot more likely in unvaccinated people than in vaccinated.

> Now, a new NIH-supported study shows that the answer to this question will vary based on how an individual’s antibodies against SARS-CoV-2 were generated: over the course of a naturally acquired infection or from a COVID-19 vaccine. The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single letter” changes in a key portion of their spike protein compared to antibodies acquired from an infection.

https://directorsblog.nih.gov/2021/06/22/how-immunity-genera...

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#58
post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

interesting, over here in germany if you (provably) had covid you don't have to get vaccinated to enter places requiring that or a test

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#59
...more or less like most infections, as has been known for centuries. And yet, due to the current "anything which doesn't make people more fearful must be suppressed" attitude, this kind of thing is news. Or would be, if the U.S. newsmedia were willing to report it, which I suspect they will not.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#60
post #53

“Acquiring” natural immunity also has the following side effects at a much higher rate than the vaccine: - Death - Hospitalization - Chronic illness, which can include long-term neurological impairment I feel like it’s important to keep that in mind if you’re either advocating “natural immunity” as a public health strategy, or considering it a personal strategy.

Vaccination also has more durable immunity than natural immunity in this case. Without those risks you outline.

* Citation needed.
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