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Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

pubmed.ncbi.nlm.nih.gov

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Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#141

Post by coldtea »

sparrc wrote: post #26

It's always strange to me how certain studies seem to gain so many upvotes on hackernews....a few thoughts: 1. This is a single study published in 2015, what does the wider literature say? Any dieticians or clinicians recommending anything from this? 2. The journal is EBioMedicine, which is not nothing but not exactly pre-eminent either. 3. This seems like just a common sense conclusion: "In Cox proportional hazard m…

>1. This is a single study published in 2015, what does the wider literature say? Any dieticians or clinicians recommending anything from this?

Dieticians and clinicians seem to say all kinds of contradicting things all the time, for half a century...

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#142

Post by coldtea »

dheera wrote: post #99
jader201 wrote: post #72

Earlier quoted context omitted.

I think you’re overthinking it. Certain studies gain so many upvotes on HN because they generate interesting discussion, and may be worth storing in our favorites for sharing and/or future reference. I almost always upvote articles when there is interesting discussion (or the potential for interesting discussion) related to the article. I very rarely (but do sometimes) upvote articles solely based on the content of t…

On the other hand, isn't it a peer-reviewed journal? If we have to do the legwork of going around asking what other clinicians think of it, it has failed at its mission as a peer-reviewed journal.

>it has failed at its mission as a peer-reviewed journal

Peer-reviewed just means:

(a) a bunch of guys had a cursory look at the research, which they might or might not be able to follow (even basic math), and left some hasty criticism on low hanging fruits (or the personal pet peeves they always mention) to pretend they thoroughly read it, and accepted it

(b) Some scholar friends accepted this as a favor to other academic friends, who will backrub them when they submit their own research, and help each other pad their paper counts

And meta-analysis means:

(c) Let's take 80 crap papers, study them as if they're relevant, and get some statistical takeways...

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#143

Post by treeman79 »

andy_ppp wrote: post #81
treeman79 wrote: post #20

Earlier quoted context omitted.

Was in a massive Sjogrens flare. Stopped eating for a month. Collapsing aside, my inflammation was fixed. Did a month on sweet potatoes. Very boring but same result.

Sjogrens sounds horrendous! I’m glad you found some way to managing the symptoms, even if quite extreme. Has it been well managed since a return to a more normal diet, have you considered OMAD instead?

In general The longer I can hold off eating the better I do during the day. At least until I collapse. If I have regular food I feel flushed and feverish. Often triggering migraines. Basically my ability to function is near zero.

Non trigger foods, ie. sweet potatoes allow me to avoid such problems.

As to well managed. No, not really. I was physically doing much better when taking proper meds, (plaqunial)

However side effects were to much.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#144

Post by Robotbeat »

mattowen_uk wrote: post #84
Robotbeat wrote: post #80

What is inflammation, exactly?

Redness round a sore or cut? Inflammation. Swollen gums around a dying tooth? Inflammation. Sore stomach due to food intolerance? Inflammation.

But what is inflammation?

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#145

Post by koolba »

b112 wrote: post #106
koolba wrote: post #50

Earlier quoted context omitted.

You could count the amount of hair loss or lack thereof. I bet hours of nightly REM sleep would be inversely correlated as well.

There is nothing wrong with hair loss, it is perfectly natural, even when young and it doesn't mean you are getting old, not even a little bit, it even can look good, OK?

I never said it’s not natural or that there’s anything wrong with it. It’s known to be associated with stress so barring other known factors, if you suddenly start losing your hair then stress could be a cause. In contrast to long term loss, short term loss from stress tends to be reversible if it’s caught early enough.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#146

Post by fsflover »

NotSammyHagar wrote: post #53
legerdemain wrote: post #5

Earlier quoted context omitted.

Serum concentration of C-reactive protein and other molecular markers of ongoing inflammation processes.

You made a lot of good comments on this article, do you have a background in nutrition?

Nice try, NSA.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#148

Post by f6v »

gogopuppygogo wrote: post #147
f6v wrote: post #98

Earlier quoted context omitted.

Was there a study?

https://pubmed.ncbi.nlm.nih.gov/31881765/

I skimmed through that review and it mostly references mice and rats, as well as cell models. There is a huge difference between that and “in most people”. In fact, you’d need a lot studies in actual people(not cell models) of different ages and and conditions to say it works.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#149

Post by imwillofficial »

NotSammyHagar wrote: post #52
imwillofficial wrote: post #42

Earlier quoted context omitted.

Subjective meaning is not no meaning. Good absolutely has a meaning. So does healthy, as does natural. Your lack of understanding of the context of use, and underlying meaning, is nobody's problem but your own. Perhaps you should have asked what He meant by clean, because clearly you don't understand.

what does clean mean to you then? Everything we consume has been modified from the original. Apples, wheat, tomatoes, corn - everything we eat has been significantly modified from what it was 10,000 years ago. Early farmers modified potatoes and everything else to grow more calories by genetic manipulation - like planting the ones that grow faster or bigger. Nothing and I mean nothing is like it was before mankind st…

Asking somebody to clarify what they mean who is using a vague phrase is useful. Telling them to stop using a phrase that you personally don’t understand is not useful.

Think of it this way, there may not be a nailed down definition of “clean” or healthy” eating. However, it gets you in a “range of uncertainty”

Is McDonalds clean? No. Is Pizza clean? Nope. Is brown rice clean? Maybe. I should ask what they mean by their usage of clean.

Have I made my point a little bitter? I view usage of vague terms like that not as useless, but as “gets you close to the target without getting lost in the weeds.”

Hope this helps.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#150

Post by andy_ppp »

jk7tarYZAQNpTQa wrote: post #127
MrBuddyCasino wrote: post #118

Earlier quoted context omitted.

> You're talking a very long time ago. We've made strong progress in food security in the last 100-200 years, not sure about before that. I suspect hunter/gatherers had it actually better than farmers. What time spans are you talking about?

> What time spans are you talking about? I would assume (from ignorance) than knowledge about food security is older than us as a species. And by food security I mean "don't eat plant A", or "don't eat plant B raw, put it first on the fire or it will make you sick" etc.

I’m not even talking about the food, more the bacteria from the environment on the food, in some places still today even the water isn’t safe to drink. You can easily have food in a developing country that makes you sick. These simply aren’t past problems and it makes sense the body mounts defences just in case!
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