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Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

pubmed.ncbi.nlm.nih.gov

91–100 of 157 posts

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#91

hi, i'm a just stupid waffle. can someone give me the TLDR of this [nearly] impossible to understand piece of writing?

From what I understand, is that if your body is quite good at fighting infection (and thus creates inflammation) you'll live longer. Seems a bit obvious to me, but what do I know? I'm not an academic scientist...

It's the other way around. Their finding is that lower levels of inflammation correlates with survival, capability and cognition in centenarians.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#92
post #14

Most people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...

Serendipitously, this popped up for me right as I was reading this thread https://www.youtube.com/watch?v=QezLxFuBxvM

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#93
post #69
post #10

Earlier quoted context omitted.

https://en.wikipedia.org/wiki/Ramdev#Claimed_cure_for_COVID-...

If there's one thing that has become apparent during COVID, it's that there is great reason to be skeptical of "official government guidelines" of in situations like COVID (acutely emerging and constantly changing scenario.) They simply can't process information fast enough to make well informed statements. Now I don't have an opinion on ayurvedic medicine and it's legitimacy but something being "banned by the govern…

Traditional auyrveda and yoga is great. Cult leaders and wondercures aren't.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#94

Earlier quoted context omitted.

From what I understand, is that if your body is quite good at fighting infection (and thus creates inflammation) you'll live longer. Seems a bit obvious to me, but what do I know? I'm not an academic scientist...

It's the other way around. Their finding is that lower levels of inflammation correlates with survival, capability and cognition in centenarians.

Ahhh. Thanks!

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#95
post #14

Most people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...

Curious – are there legitimate ways to measure stress?

Heart Rate Variability (HRV), a relatively new feature in wearables with optical heart rate monitors, is a good proxy for stress. Some years ago, IBM did a study that found that HRV in newborns served as an early warning system of illness. Athletes have long used this measure to determine when off days are needed.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#96
post #56

Earlier quoted context omitted.

yet everyone in the comments is sounding off as if this scientifically proves their random anecdotes about fasting

What’s wrong with fasting, isn’t it likely to increase life expectancy. I certainly feel better from this attempt at Ramadan (not religious just interested to try it as flat mate is Syrian). What evidence do you have that fasting -> less inflammation -> better ageing is wrong?

> What evidence do you have that fasting -> less inflammation -> better ageing is wrong?

It’s wrong to frame the question as you did. The evidence should be provided to prove something, not disprove it. Is there enough evidence that fasting ultimately leads to better aging? If so, for which groups of people? Is there any underlying condition that negates the effect? That’s how science work, not the other way around.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#97
post #14

Most people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...

We’re just scratching the surface there. So many things can go wrong with the immune system that lead to inflammation.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#98
post #14

Most people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...

CBD is great at helping alleviate inflammation in most people.

Was there a study?

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#99
post #26

It's always strange to me how certain studies seem to gain so many upvotes on hackernews....a few thoughts: 1. This is a single study published in 2015, what does the wider literature say? Any dieticians or clinicians recommending anything from this? 2. The journal is EBioMedicine, which is not nothing but not exactly pre-eminent either. 3. This seems like just a common sense conclusion: "In Cox proportional hazard m…

I think you’re overthinking it. Certain studies gain so many upvotes on HN because they generate interesting discussion, and may be worth storing in our favorites for sharing and/or future reference. I almost always upvote articles when there is interesting discussion (or the potential for interesting discussion) related to the article. I very rarely (but do sometimes) upvote articles solely based on the content of t…

On the other hand, isn't it a peer-reviewed journal? If we have to do the legwork of going around asking what other clinicians think of it, it has failed at its mission as a peer-reviewed journal.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#100
post #44

Epigenetic clocks measuring methylation sites across DNA are currently the most accurate way to measure aging https://en.wikipedia.org/wiki/Epigenetic_clock What's more, it seems that it is possible to reset the epigenetic of cells to their youthful state and reverse actual the biological age of those cells. They don't just "measure younger", they function as they did when they were younger. https://www.nature.com/ar…

interesting, what are your thoughts on modifying our epigenetics via crisper to pulse Yamanaka factors? also what ever happened to that CEO who gave her immune system a boost with stem cells?
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