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Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

pubmed.ncbi.nlm.nih.gov

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Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#111

Post by nabla9 »

legerdemain wrote: post #7
TimSchumann wrote: post #3

Anecdote, but this may explain why I feel so much healthier when I'm fasting regularly. Turns out, if you stop putting everything but water/salt in your body, there's not much left that causes inflammation.

Inflammation is a basic life process, not a reaction to the food you eat. Inflammation plays an active part in wound-healing. Teething in infants has an inflammatory component. Systemic inflammation is ubiquitous during and following parturition in mammals. There is inflammation everywhere, it's as generic a word as "oxidation" and "metabolism."

Inflammation is immune system response. Nothing to do with metabolism or oxidation.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#112

Post by PartiallyTyped »

kbaker wrote: post #49
NotSammyHagar wrote: post #32

Earlier quoted context omitted.

Come on, don't use the word clean with regards to diet. It's a bs and meaningless word that specifies nothing. Is it no sugar, no salt, no meat, no gc organisms, no alcohol no processed, low carb, high carb? Clean is a word that suggests Instagram influencers. Clean does not mean bland or not bland, whole foods or not. It's a meaningless word like good, healthy, natural.

I mean, they did qualify it in the same sentence with "different foods, processed stuff, fast food, alcohol, harsh additives, fried/burned food etc. on occasion". Although I don't know any diet that would be "clean" compared with a water fast...

> Although I don't know any diet that would be "clean" compared with a water fast...

Vegan perhaps?

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#113

Post by nabla9 »

NotSammyHagar wrote: post #53
legerdemain wrote: post #5

Earlier quoted context omitted.

Serum concentration of C-reactive protein and other molecular markers of ongoing inflammation processes.

You made a lot of good comments on this article, do you have a background in nutrition?

He has made horrible comments like

> There is inflammation everywhere, it's as generic a word as "oxidation" and "metabolism."

He is probably googling for answers and making it up as he goes.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#114

Post by Broken_Hippo »

tittenfick wrote: post #103
m463 wrote: post #102

Earlier quoted context omitted.

All the things I've listened to regarding health an longevity have a recurring theme - inflammation happens a lot in modern life - and it decreases your lifespan. I think type 2 diabetes is basically an inflammatory disease. More and more people are "pre-diabetes", which is basically lifestyle moving them towards type 2 diabetes.

But inflammation is just the body's natural respond to disease. Claiming inflammation hurts you is like saying wet streets cause rain.

Inflammation can be good or bad.

You really don't want a section of a nerve to be inflamed because the body is attacking the coating, for example. You do, however, want the skin surrounding the scratch on your leg to have some inflammation to help close the cut.

None of this means you should regularly take an anti-inflammatory drug nor does it mean that an "anti-inflammatory" diet or other preventative measures will help, either. I view some of this as the latest pseudo-science, at least in the hands of most folks.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#115

Post by adamjb »

dheera wrote: post #99
jader201 wrote: post #72

Earlier quoted context omitted.

I think you’re overthinking it. Certain studies gain so many upvotes on HN because they generate interesting discussion, and may be worth storing in our favorites for sharing and/or future reference. I almost always upvote articles when there is interesting discussion (or the potential for interesting discussion) related to the article. I very rarely (but do sometimes) upvote articles solely based on the content of t…

On the other hand, isn't it a peer-reviewed journal? If we have to do the legwork of going around asking what other clinicians think of it, it has failed at its mission as a peer-reviewed journal.

You have a weird view of academia

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#116

Post by jk7tarYZAQNpTQa »

andy_ppp wrote: post #71
rsync wrote: post #59

Earlier quoted context omitted.

"Inflammation is a basic life process, not a reaction to the food you eat. Inflammation plays an active part in wound-healing. Teething in infants has an inflammatory component. Systemic inflammation is ubiquitous during and following parturition in mammals. There is inflammation everywhere, it's as generic a word as "oxidation" and "metabolism."" Everything you have said is true. What I think you are missing is that…

Yes, also we know cell machinery operates in a different mode when the body is without fuel, it’s moves in a repair/conserve mode that includes preferential autophagy of damaged cells. It makes sense, eating used to be extremely dangerous so the body mounts an immune response including inflammation every time.

> eating used to be extremely dangerous

You're talking a very long time ago. Shouldn't that be already disregarded from an evolutionary POV?

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#117

Post by jk7tarYZAQNpTQa »

NotSammyHagar wrote: post #32
kossTKR wrote: post #8

Earlier quoted context omitted.

Same here. It's the closest thing to an actual wonder drug i have ever come across. My skin clears up, brainfog disappears, the white in my eyes get brighter, etc. After reading a bit i have come to the same conclusion - if your diet is already extremely clean / bland, maybe you won't get the same effect, but for most people that eats lots of different foods, processed stuff, fast food, alcohol, harsh additives, frie…

Come on, don't use the word clean with regards to diet. It's a bs and meaningless word that specifies nothing. Is it no sugar, no salt, no meat, no gc organisms, no alcohol no processed, low carb, high carb? Clean is a word that suggests Instagram influencers. Clean does not mean bland or not bland, whole foods or not. It's a meaningless word like good, healthy, natural.

> It's a bs and meaningless word that specifies nothing

It's neither bs nor meaningless. It intuitively describes a good diet if you have a basic knowledge of food and diet. It basically means "what is good for you". What would you describe as "clean", deep fried butter or broccoli sprouts? See how it's intuitive?

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#118

Post by MrBuddyCasino »

jk7tarYZAQNpTQa wrote: post #116
andy_ppp wrote: post #71

Earlier quoted context omitted.

Yes, also we know cell machinery operates in a different mode when the body is without fuel, it’s moves in a repair/conserve mode that includes preferential autophagy of damaged cells. It makes sense, eating used to be extremely dangerous so the body mounts an immune response including inflammation every time.

> eating used to be extremely dangerous You're talking a very long time ago. Shouldn't that be already disregarded from an evolutionary POV?

> You're talking a very long time ago.

We've made strong progress in food security in the last 100-200 years, not sure about before that. I suspect hunter/gatherers had it actually better than farmers. What time spans are you talking about?

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#119

Post by samus »

tittenfick wrote: post #103
m463 wrote: post #102

Earlier quoted context omitted.

All the things I've listened to regarding health an longevity have a recurring theme - inflammation happens a lot in modern life - and it decreases your lifespan. I think type 2 diabetes is basically an inflammatory disease. More and more people are "pre-diabetes", which is basically lifestyle moving them towards type 2 diabetes.

But inflammation is just the body's natural respond to disease. Claiming inflammation hurts you is like saying wet streets cause rain.

This is slightly incorrect, because inflammation is not only triggered by "diseases". Inflammation indeed hurts the body. Some of the weapons it deploys, for example Neutrophil extracellular traps (basically, playing Spider Man with webs of DNA) make subsequent cadiovascular disease more likely. Others are just generally bad for the body or uncomfortable (fever, ratches, ulcers).

Chronic systemic inflammation is known to play a role in the development and progression of coronary heart disease and diabetes, and accelerate the transformation of the immune system into an aged state, which makes it more likely to develop immune system disregulations such as autoimmune diseases, and to cause cytokine storms when exposed to agents such a N1H1, Epstein-Barr or Covid.

The immune system consists of many moving parts coordinating each other via the exchange of signalling molecules, which results in a large distributed system with lots of unintuitive emergent behaviors. We are only just starting to understand what effects our everyday behavior has on the immune system, and what happens to it when we age.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#120

Post by samus »

tittenfick wrote: post #105
m463 wrote: post #104

Earlier quoted context omitted.

It might also be the body's natural response to a poor diet, or carrying too much weight.

Yes, you're more vulnerable to disease when you are living an unhealthy lifestyle. Shocker.

Please define "unhealthy". This is a higly ambiguous term, and its definition differs a lot between cultures and across time, therefore it is far from obvious what living an unhealthy lifestyle means.
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