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Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

pubmed.ncbi.nlm.nih.gov

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Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#121

Post by [deleted] »

jader201 wrote: post #72
sparrc wrote: post #26

It's always strange to me how certain studies seem to gain so many upvotes on hackernews....a few thoughts: 1. This is a single study published in 2015, what does the wider literature say? Any dieticians or clinicians recommending anything from this? 2. The journal is EBioMedicine, which is not nothing but not exactly pre-eminent either. 3. This seems like just a common sense conclusion: "In Cox proportional hazard m…

I think you’re overthinking it. Certain studies gain so many upvotes on HN because they generate interesting discussion, and may be worth storing in our favorites for sharing and/or future reference. I almost always upvote articles when there is interesting discussion (or the potential for interesting discussion) related to the article. I very rarely (but do sometimes) upvote articles solely based on the content of t…

[deleted]

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#122

Post by vimy »

ryandvm wrote: post #36
TimSchumann wrote: post #3

Anecdote, but this may explain why I feel so much healthier when I'm fasting regularly. Turns out, if you stop putting everything but water/salt in your body, there's not much left that causes inflammation.

My experience with a 3 day fast was that for the first day it was no problem. I can generally ignore hunger pretty easily. But days 2 and 3 were just a brutal lack of energy. I have never felt so depleted as when I was finishing my 3-day fast. Other than that, I didn't really experience any positive benefits.

Probably had more to do with electrolytes being depleted than hunger.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#123

Post by andy_ppp »

f6v wrote: post #96
andy_ppp wrote: post #70

Earlier quoted context omitted.

What’s wrong with fasting, isn’t it likely to increase life expectancy. I certainly feel better from this attempt at Ramadan (not religious just interested to try it as flat mate is Syrian). What evidence do you have that fasting -> less inflammation -> better ageing is wrong?

> What evidence do you have that fasting -> less inflammation -> better ageing is wrong? It’s wrong to frame the question as you did. The evidence should be provided to prove something, not disprove it. Is there enough evidence that fasting ultimately leads to better aging? If so, for which groups of people? Is there any underlying condition that negates the effect? That’s how science work, not the other way around.

I guess we will see who is right once the studies are done. There is definitely proof that fasting reduces inflammation, if reducing inflammation helps with ageing is being worked on by people like David Sinclair at Harvard and others.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#124

Post by tartoran »

JMTQp8lwXL wrote: post #17
tartoran wrote: post #9

Earlier quoted context omitted.

That's like saying cell division is a basic life process and nothing can stop this process from going haywire, but what about cancer. It is widely believed that inflammation levels spike for certain foods and the overall effect on the body is not optimal to say the least.

There's a middle ground: some is probably beneficial in certain cases, but you can have too much of a good thing-- then it's an issue.

Yes, that is obvious. It is a natural process as much as apoptosis or cell suicide is.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#125

Post by bregma »

andreygrehov wrote: post #38
asadkn wrote: post #14

Most people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...

Curious – are there legitimate ways to measure stress?

Stress is measured in metric units of "handwaves." One handwave (Ɦ)is 1 angst (å) per second.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#126

Post by chub500 »

perl4ever wrote: post #46
kgin wrote: post #44

Epigenetic clocks measuring methylation sites across DNA are currently the most accurate way to measure aging https://en.wikipedia.org/wiki/Epigenetic_clock What's more, it seems that it is possible to reset the epigenetic of cells to their youthful state and reverse actual the biological age of those cells. They don't just "measure younger", they function as they did when they were younger. https://www.nature.com/ar…

>currently the most accurate way to measure aging I don't understand what people mean by statements like this. Per the Wiki page, they found something that on average is highly correlated to chronological age. But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise? What is the reference point for the "real" age that is not chronological age?

I just watched an interesting Veritasium on this aspect of aging: https://m.youtube.com/watch?v=QRt7LjqJ45k

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#127

Post by jk7tarYZAQNpTQa »

MrBuddyCasino wrote: post #118
jk7tarYZAQNpTQa wrote: post #116

Earlier quoted context omitted.

> eating used to be extremely dangerous You're talking a very long time ago. Shouldn't that be already disregarded from an evolutionary POV?

> You're talking a very long time ago. We've made strong progress in food security in the last 100-200 years, not sure about before that. I suspect hunter/gatherers had it actually better than farmers. What time spans are you talking about?

> What time spans are you talking about?

I would assume (from ignorance) than knowledge about food security is older than us as a species. And by food security I mean "don't eat plant A", or "don't eat plant B raw, put it first on the fire or it will make you sick" etc.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#128

Post by Retric »

dheera wrote: post #99
jader201 wrote: post #72

Earlier quoted context omitted.

I think you’re overthinking it. Certain studies gain so many upvotes on HN because they generate interesting discussion, and may be worth storing in our favorites for sharing and/or future reference. I almost always upvote articles when there is interesting discussion (or the potential for interesting discussion) related to the article. I very rarely (but do sometimes) upvote articles solely based on the content of t…

On the other hand, isn't it a peer-reviewed journal? If we have to do the legwork of going around asking what other clinicians think of it, it has failed at its mission as a peer-reviewed journal.

Peer review only is the initial smell test, and don’t mean it’s actually true. Fraud for example can often pass peer review just fine. That said, it does catch errors and rejects a lot of junk which is why it’s considered important.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#129

Post by refurb »

dheera wrote: post #99
jader201 wrote: post #72

Earlier quoted context omitted.

I think you’re overthinking it. Certain studies gain so many upvotes on HN because they generate interesting discussion, and may be worth storing in our favorites for sharing and/or future reference. I almost always upvote articles when there is interesting discussion (or the potential for interesting discussion) related to the article. I very rarely (but do sometimes) upvote articles solely based on the content of t…

On the other hand, isn't it a peer-reviewed journal? If we have to do the legwork of going around asking what other clinicians think of it, it has failed at its mission as a peer-reviewed journal.

No, peer review is “there doesn’t seem to be an major errors and the thinking is reasonable”

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#130

Post by atat7024 »

andy_ppp wrote: post #76
atat7024 wrote: post #16

Earlier quoted context omitted.

Every time you eat, the body enters a state of heightened inflammation. This is well documented. Please don't spread disinformation.

https://www.sciencedaily.com/releases/2017/01/170116121912.h... For example suggests this is true...

Yeah, honestly this is no different than real life.

People don't want to be told that alcohol, sugar, too many calories, etc inflames the hell out of the body. So be it.

Wait for your own wakeup call. I hope it never comes.

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