I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…
What's your take on allowing a substance to change you so much?
Psilocybin 'promising' for depression
181–190 of 324 posts
Re: Psilocybin 'promising' for depression
#182They gave psilocybin in much lower dose to the placebo group... I wonder what the point of that was... it could still be affecting them.
Psylocybin usually comes with obvious hallucinogenic or physiological effects. The placebo group would instantly realize they have been given a placebo if no physiological effects appear at all, hereby making the blind study useless.
The Charité hospital in Berlin is starting a similar study sometime in summer of this year. The setup is that the control/placebo group (instead of Psylocybin) receives a dosage of Niacin [1]. This causes a "flushing" effect[2] in the test subject and in this way can trick them into believing they have indeed received Psylocybin.
Re: Psilocybin 'promising' for depression
#183For those curious: you can cultivate your own at home. It’s 100% legal to purchase psilocybin spores online in many states. I just had to throw out a grow due to contamination - super frustrating setback - but I’m determined to produce a healthy harvest.
Before anyone rushes to do this: Cultivating these mushrooms is not legal, even if buying the spores might be. Likewise, self-medicating severe depression with hone grown psychedelics is not a great idea. These studies use controlled administration in supervised environments often with therapy as part of the process. You cannot replicate that at home. Psychedelics also can’t be dosed continuously like traditional ant…
Re: Psilocybin 'promising' for depression
#184I feel like there will also people that have way too many prejudices towards these kinds of "drugs" because that's simply how we learned it. "Don't take drugs kids". These studies are very helpful especially when shared over general media, but the consumption has to be supervised and controlled to not have overdoses and ruin the whole reputation again. It should be treated like any other anti-depressant, since they a…
We need to change the message from "don't take drugs" to "if you choose to take drugs, take them responsibly". Start with low doses, don't mix (alcohol,benzo,opiates), and remember that unless taken therapeutically, drugs should be an occasional party thing and not an escapism for life. It's also totally fine to not do drugs. I'm going sober (except a beer or two) for an indefinite period of time, just because that's…
The phrase for this is “harm reduction” and it has been around for a few decades in the pro-drug communities.
The challenge is that harm reduction material is largely targeted at avoiding overdoses or fatal combinations as you mentioned, which can give users a false sense of confidence about their ability to avoid addiction.
I’ve watched a couple close acquaintances slowly decline over time due to what they thought was responsible drug use. You can do all the right things and still end up addicted to and dependent upon addictive drugs. Fortunately they were both able to afford rehabilitation programs that got them back on track.
I visited one of them in the rehab program. The price tag was high so selection bias was obviously at play, but it was interesting to see that every person there was also an adult professional who thought they were smart enough and self-educated enough about drugs to avoid succumbing to addiction, which was clearly not the case.
I don’t have any answers or solutions to the topic, but I do know that addiction is a risk that most addicts seem to downplay at the start of their experiences. Few people go into drug habits expecting to become dependent.
Perhaps more interesting is the uptick in people addicted to psychedelics, partially driven by the growing perception that they’re not addictive. It seems that these patients aren’t addicted in the traditional sense of becoming dependent, but they get hooked on the escapism aspect or the idea that they’re just one or two trips away from a major epiphany. Not all of the rewiring that takes place in these experiences is necessarily in a healthy direction. It can happen, so people should at least be aware of it.
Re: Psilocybin 'promising' for depression
#185I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…
Would your friend have advice or resources on how to give microdosing a try, especially for people who've never done psychedelics?
Re: Psilocybin 'promising' for depression
#186Earlier quoted context omitted.
In what way were their minds ruined?
Any psychadelics (and I think cannabis as well, but much more rarely) can cause a psychotic break, which can’t always be recovered from. It seems to be more prevalent if there is a family history of psychosis. No source, just anecdata, the circles I run in.
Re: Psilocybin 'promising' for depression
#187Earlier quoted context omitted.
I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.
At least some of this could be the tendency of people with pre-existing mental illness to self-medicate. High smoking rates amongst people with schizophrenia is an example. Smoking seems to ameliorate some psychotic symptoms.
Re: Psilocybin 'promising' for depression
#188Me and my girlfriend are microdosing LSD for the past couple of weeks. We both are very outgoing persons, but due to Corona, our life is really boring which makes our mental state not as positive as it was. We notice that we have more acceptance to the Corona situation. Especially the “bad” days, the microdosis makes the day much more acceptable.. I’m aware that this is a very brief explanation. If you are very inter…
Re: Psilocybin 'promising' for depression
#189I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…
I have zero experience with drugs, so I am wondering if there is a sugar/cigarette industry that put a lot of money into promoting it's products, then what will be different when drugs get legalized? Won't we repeat the history where companies make billions from this products, put them into ads to spread the use and addict people, suppress research into bad side effects etc,. Personally I think there are some good ap…
Re: Psilocybin 'promising' for depression
#190I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…
What's your take on allowing a substance to change you so much?