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Suppressing a gene by using its antibody can lead to tooth growth: animal study

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Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#141

Post by matheusmoreira »

mdpopescu wrote: post #94
NiceWayToDoIT wrote: post #92

Although amazing, I am following similar news for last 20 years, and promise of tooth regrowth was as a holly grail of dental health, but on the other side it is similar like a nuclear fusion always 20 years away. Process goes like this, "big news -> excitement -> and then nothing -> few years later again nothing -> you go to you dentist for regular check and when you ask he laughs in your face." I read about steam c…

As a general rule, the entire medical profession has the incentives set up the wrong way - the more problems you have, the more they benefit. I have read that there was a time, in the distant past, where you paid a doctor only as long as you were healthy. I can come up with some problems even in that case, but I can't help but think it might still be an improvement over the current situation...

As a general rule doctors always do what they believe is best for their patients. I don't think I've ever seen one intentionally harm patients in order to keep them coming back. There are so many people in need that doing such a thing would be pointless anyway.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#143

Post by jjk166 »

raducu wrote: post #122
mdpopescu wrote: post #94

Earlier quoted context omitted.

As a general rule, the entire medical profession has the incentives set up the wrong way - the more problems you have, the more they benefit. I have read that there was a time, in the distant past, where you paid a doctor only as long as you were healthy. I can come up with some problems even in that case, but I can't help but think it might still be an improvement over the current situation...

There's overwhelming evidence against such a broad statement. There are good mechanics, cars are getting safer, cops do fight crime, soldiers do fight wars and so on, social workers so do their jobs, teachers usually teach and so on. You can say the same for every kind of work -- that you are incentivized to do a poor work so that there's more demand for the work, but the counter incentive is the free market. If othe…

> There are good mechanics, cars are getting safer, cops do fight crime, soldiers do fight wars and so on, social workers so do their jobs, teachers usually teach and so on.

But there also exist many mechanics who try to get you to pay for unnecessary services, which mechanics are incentivized for.

Cars are getting safer for their human passengers by increasing the energy absorbed by the car body, which coincidentally increases the odds of a car being totaled in an accident, which increases demand for cars, which is what car manufacturers are incentivized for.

Cops are incentivized to make lots of arrests - which means they mostly fight crime which doesn't require extensive investigation nor poses high risk, ie lots of low level non-violent crimes.

Soldiers are not incentivized to prolong wars (they get paid in peace time, which also has much lower risks of death and disability). Major defense contractors and some politicians though do have an incentive to prolong wars, and coincidentally the US has been continuously at war for nearly 20 years.

How many major cities have had a serious social problem eliminated by the efforts of social workers? That's not their job, which is why it doesn't get done.

Teachers have no perverse incentive not to teach, they don't get paid more if their students don't pass. In fact it's a real problem where schools that have poor performance for unrelated reasons get punished with reduced funding, leading to a downward spiral that has destroyed lots of inner city schools. Even if the government doesn't formally have such punitive measures in place, the fact is wealthy families move away from mediocre school districts, which reduces the funding available for them, which quickly leads to the school district becoming even worse.

Perverse incentives don't mean you're incentivized to do your job poorly, it means the job you're incentivized to do well isn't necessarily the one people would want you to do.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#144

Post by ectopod »

trident5000 wrote: post #7
MauranKilom wrote: post #4

Earlier quoted context omitted.

Just pull all teeth and let them regrow at the same time, of course. Next!

I know you're joking but theres actually people who would pray for a treatment exactly like this. The elderly in particular. Over time all your teeth go. When I'm 60 I wouldnt mind them just ripping them all out if I could regrow them in 3 months.

> The elderly in particular. Over time all your teeth go.

This was the view of dentists before WWII. Both of my grandmothers had all their teeth pulled before they were thirty when there was very little wrong with them. "You'll lose them anyway, why not get a nice set of dentures?" They both regretted taking their dentists' advice. My octogenarian mother grew up in a more enlightened age and she still has her teeth. Tooth loss is not inevitable.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#145

Post by ectopod »

airhead969 wrote: post #69
King-Aaron wrote: post #42

Earlier quoted context omitted.

I'd just hope that the new teeth at least grow in the mouth

On my hands or on my johnson wouldn't be good.

People have been worrying about such things for centuries.

https://en.wikipedia.org/wiki/Vagina_dentata

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#146

Post by helloworld11 »

bigmattystyles wrote: post #62
throwawayboise wrote: post #5

Earlier quoted context omitted.

Don't rodent teeth grow continuously anyway? That's why they're always gnawing on stuff.

Yea, I remember seeing a picture on reddit years ago where a squirrel, feasting on soft human trash, his teeth didn't wear down and grew outwards in concentric circles until he presumably starved from now not being able to chew even the softest of foods. I don't want to look up the photo, it's sad, but I think it was legit.

At first I read your comment as saying "feasting on soft human flesh" and had some very serious questions about the benefits of helping that squirrel fix its teeth again...

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#147

Post by bionhoward »

raducu wrote: post #120
NiceWayToDoIT wrote: post #92

Although amazing, I am following similar news for last 20 years, and promise of tooth regrowth was as a holly grail of dental health, but on the other side it is similar like a nuclear fusion always 20 years away. Process goes like this, "big news -> excitement -> and then nothing -> few years later again nothing -> you go to you dentist for regular check and when you ask he laughs in your face." I read about steam c…

Because any regrowth solution would be quite expensive, time consuming and prone to problems. It would likely be performed by surgeons and monitored by orthodontists there couls be multiple teeth comming out, missaligned and so forth. I'd much rather do things the old fashion way than risk all sorts of problem down the line, have multiple trips, wait months upon months for my teeth to regrow. As a last resort, or ins…

Regeneration need not be expensive. The cells can do the work, as evidenced by the embryo. We just have to figure out how to tell the cells to do it again. And, critically, tell them to stop when they're done...

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#148

Post by throw1234651234 »

spyder wrote: post #80
elsonrodriguez wrote: post #64

Earlier quoted context omitted.

Sensodyne does not have Novamin in the USA(insert conspiracy theory here). You'd either have to import it from a reputable supplier, or try an alternative like Apagard or Biomin F(both of those have to be imported too, but are more readily available).

Article from 2018 about that: "As of the time of this update, Sensodyne toothpaste with NovaMin is now available on Amazon to buyers in the USA, directly from Sensodyne/GSK." https://medium.com/@ravenstine/the-curious-history-of-novami... https://www.amazon.com/Sensodyne-Protect-Whitening-Toothpast...

That article really helped me understand what this is all about, ty!

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#149

Post by Black101 »

nickspacek wrote: post #137
Black101 wrote: post #109

Earlier quoted context omitted.

I ordered some from Canada, made in Canada, using Ebay (about as reliable as Amazon but it doesn't come from India and it is cheaper).

I went looking on Ebay but couldn't find anything in Canada, do you mind sharing the brand or keyword?

Sorry I was talking about the Novamin one... I think the nano-hydroxyapatite one is available in the US.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#150

Post by throw1234651234 »

NiceWayToDoIT wrote: post #92

Although amazing, I am following similar news for last 20 years, and promise of tooth regrowth was as a holly grail of dental health, but on the other side it is similar like a nuclear fusion always 20 years away. Process goes like this, "big news -> excitement -> and then nothing -> few years later again nothing -> you go to you dentist for regular check and when you ask he laughs in your face." I read about steam c…

Unfortunately, stuff like this is what makes it clear to me that all claims of slowing aging / reversal are a complete joke. We can't even put a hard layer on a tooth that mimics a natural layer, seriously? Not to mention that we can't prevent baldness, nor do we REALLY know how much muscle control can reverse myopia. We can't even re-attach nails to the nail base, etc, etc, etc.
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