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Suppressing a gene by using its antibody can lead to tooth growth: animal study

u-fukui.ac.jp

71–80 of 163 posts

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#71
post #46
post #33

Earlier quoted context omitted.

I don't know. We see pharma companies killing one-time cures to not cannibalise recurring treatments, even if another company makes the recurring treatments.

Where have we seen this? Genuine question.

Not exactly an example, but the pharma industry has shown a complete lack of interest in pursuing phage therapy, even though it could help solve the problem of antibiotic resistance, because phages cannot be patented.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#72
post #39
post #35

Earlier quoted context omitted.

Is being 41 an achievement?

Yes, because next year s/he will realize the meaning of life, the universe and everything.

I just turned 43. Babelfish won't help. Get laid as much as you can, eat more fiber, ease off the substances, and DGAFs.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#73
post #71
post #46

Earlier quoted context omitted.

Where have we seen this? Genuine question.

Not exactly an example, but the pharma industry has shown a complete lack of interest in pursuing phage therapy, even though it could help solve the problem of antibiotic resistance, because phages cannot be patented.

I’ve heard phage therapy is very individual and cannot be scaled as a reason for slow adoption.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#75
post #31

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

It's so sad that most dentists optimise for billable revenue, even at the detriment of long term patient health. Fillings for example always degrade and need repairs after X years. Drilling and filling even the smallest cavity puts that teeth on a lifetime progression to bigger and bigger fillings, eventually a root canal, eventually an implant. Cavities, on the other hand can be arrested (stopped), and if small can…

[deleted]

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#76
post #31

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

It's so sad that most dentists optimise for billable revenue, even at the detriment of long term patient health. Fillings for example always degrade and need repairs after X years. Drilling and filling even the smallest cavity puts that teeth on a lifetime progression to bigger and bigger fillings, eventually a root canal, eventually an implant. Cavities, on the other hand can be arrested (stopped), and if small can…

> It's so sad that most dentists optimise for billable revenue

I've heard this so often as well as the more general statement that doctors optimize for revenue. I think it's nonsense and even dangerous. People are more likely to die from deadly diseases like cancer because they avoid doctors. The anti-vaccination movement is also very likely linked to this sentiment.

> Cavities, on the other hand can be arrested (stopped),

If they are really small. And even if, teeth with rough surface require multiple times more effort to take care of. (So you really need to chew a lot of gum) Only exception are deep holes, those you sometimes don't want to fill so the tooth can "breathe", at least for some years IIRC.

> and if small can even be remineralised. Yes, most dentists don't tell you that!

2 out of 3 dentists told me to buy remineralization tooth paste and use it once a week. Also I'm getting urged nowadays to go twice a year for tooth cleaning including professional remineralization treatment.

Disclaimer: Not a dentist either. I think medical advice should be taken from people that have actually studied that stuff.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#77
post #31

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

It's so sad that most dentists optimise for billable revenue, even at the detriment of long term patient health. Fillings for example always degrade and need repairs after X years. Drilling and filling even the smallest cavity puts that teeth on a lifetime progression to bigger and bigger fillings, eventually a root canal, eventually an implant. Cavities, on the other hand can be arrested (stopped), and if small can…

> Listen to your dentist you trust

Sure, but it's tough to find a dentist since:

> most dentists optimise for billable revenue

I find it hard to trust dentists since they may exaggerate cavities to put money in their pocket.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#78
post #31

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

It's so sad that most dentists optimise for billable revenue, even at the detriment of long term patient health. Fillings for example always degrade and need repairs after X years. Drilling and filling even the smallest cavity puts that teeth on a lifetime progression to bigger and bigger fillings, eventually a root canal, eventually an implant. Cavities, on the other hand can be arrested (stopped), and if small can…

My dentist friend claims he makes far more money per hour from cleanings than from fillings. This is because most of a cleaning is done by a relatively lowly paid hygienist but still requires him popping in for 5 minutes and a filling requires him to be there the whole time.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#79
I highly doubt this is intentional, but I wanted to point out a little fun play on words here: USAG-1 written down looks a lot like "usagi" (兎), which in Japanese means "rabbit" – an animal known for its teeth, among other things. :)

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#80

Earlier quoted context omitted.

I have never heard of this Novamin toothpaste before. Nor has any of my dentists ever recommended it. It looks like the popular brand is Sensodyne.

Sensodyne does not have Novamin in the USA(insert conspiracy theory here). You'd either have to import it from a reputable supplier, or try an alternative like Apagard or Biomin F(both of those have to be imported too, but are more readily available).

Article from 2018 about that:

"As of the time of this update, Sensodyne toothpaste with NovaMin is now available on Amazon to buyers in the USA, directly from Sensodyne/GSK."

https://medium.com/@ravenstine/the-curious-history-of-novami...

https://www.amazon.com/Sensodyne-Protect-Whitening-Toothpast...

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