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Suppressing a gene by using its antibody can lead to tooth growth: animal study

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31–40 of 163 posts

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#31

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

It's so sad that most dentists optimise for billable revenue, even at the detriment of long term patient health.

Fillings for example always degrade and need repairs after X years. Drilling and filling even the smallest cavity puts that teeth on a lifetime progression to bigger and bigger fillings, eventually a root canal, eventually an implant.

Cavities, on the other hand can be arrested (stopped), and if small can even be remineralised. Yes, most dentists don't tell you that!

Careful monitoring and patient education on the other hand can lead to permanently keeping that natural teeth, as our teeth are living and can heal.

My personal lived experience: a dentist told me I must fill 2 cavities six years ago. I got a second opinion. That dentist told me I should wait, focus on oral care, chew xylitol gum, and use a toothpaste with novamin.

Both cavities have "arrested" and need no restorative work.

Disclaimer: Not a dentist. Listen to your dentist you trust, and get second opinions if you have doubt.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#32

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

Consumers would beat a path to the door of the dentists that offered this. They would make tons of money. The dentists not offering this product would lose customers and go out of business.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#33

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

Consumers would beat a path to the door of the dentists that offered this. They would make tons of money. The dentists not offering this product would lose customers and go out of business.

I don't know. We see pharma companies killing one-time cures to not cannibalise recurring treatments, even if another company makes the recurring treatments.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#34
post #23

Earlier quoted context omitted.

Maybe not that long. I'm 41 and have dentures. 18% of people 33-45 have them. 3% of people 18-33 have dentures. I've got a full denture with implant posts on the top, and a partial on the bottom. It's not just a "given" that teeth will hold out till retirement age.

Perhaps this is a regional variation of English but here in the US I've never heard anybody refer to non-removal dental implants as dentures before.

Dentures sometimes are attached to implants (the screws in your jaw).

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#35

Earlier quoted context omitted.

Maybe not that long. I'm 41 and have dentures. 18% of people 33-45 have them. 3% of people 18-33 have dentures. I've got a full denture with implant posts on the top, and a partial on the bottom. It's not just a "given" that teeth will hold out till retirement age.

18% sounds so high. What’s it like living with them? Any problems? Also congrats on being 41!

Is being 41 an achievement?

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#38

The article linked says it causes new teeth to grow in rats and ferrets, and that pugs and dogs are next. It doesn't however talk about targeting that growth to a particular place.

Thanks for giving me nightmares tonight.

For your dreaming (dis)pleasure: https://www.youtube.com/watch?v=402xHwQGVsE

(Conehead goes to the dentist)

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#39
post #35

Earlier quoted context omitted.

18% sounds so high. What’s it like living with them? Any problems? Also congrats on being 41!

Is being 41 an achievement?

Yes, because next year s/he will realize the meaning of life, the universe and everything.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#40
post #16

I hope someone works on recovering UOX (Urate Oxidase)[1] gene resurrection. It disappeared in one of our predessors making us prone to gout and excessive fat deposition[2]. Recovering this gene will treat both at the same time. [1] https://www.genecards.org/cgi-bin/carddisp.pl?gene=UOX [2] https://www.nature.com/articles/s41366-019-0487-9

I think you have misread the second paper. Mendelian randomization can be a confusing technique.

>Uric acid wGRS was not associated with fasting serum glucose, HbA1C, waist circumference, or BMI. On the other hand, waist circumference was causally associated with all the components of MetS including uric acid.

Here's what's happening: some genes are known to be associated with elevated uric acid. Other genes are known to be associated with increased waist circumference. Because several different genes are considered, it is assumed that the "side-effects" of these genes can be neglected; the failure of this assumption is called horizontal pleiotropy, and I don't feel confident assessing their methods on this point. MR is generally considered to provide a better degree of causality estimation than longitudinal data, because the genetic factors can be considered "prior" to other effects.

The authors find that the genes associated with uric acid are associated with worse cardiovascular symptoms, while they are not associated with other symptoms of metabolic syndrome; waist circumference genes are associated with all of the symptoms of metabolic syndrome. Also, the effect of weight circumference genes on uric acid levels is significant, while the effect of uric acid genes on waist circumference is not (a strange asymmetry, but I guess it makes sense).

So what the study really shows is that elevated uric acid appears to contribute to worse blood parameters. However, it doesn't contribute much to central adiposity.

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