The article linked says it causes new teeth to grow in rats and ferrets, and that pugs and dogs are next. It doesn't however talk about targeting that growth to a particular place.
Thanks for giving me nightmares tonight.
Suppressing a gene by using its antibody can lead to tooth growth: animal study
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Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#12In mice.
The headline could use some "in mice" in it.
Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#13Earlier quoted context omitted.
Just pull all teeth and let them regrow at the same time, of course. Next!
I know you're joking but theres actually people who would pray for a treatment exactly like this. The elderly in particular. Over time all your teeth go. When I'm 60 I wouldnt mind them just ripping them all out if I could regrow them in 3 months.
Wouldn't they fall out like baby teeth do if new teeth grow under to push them out?
Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#14> They found, with animal studies, that suppressing the gene USAG-1 by using its antibody can efficiently lead to tooth growth. And we're sure that suppressing USAG-1 (uterine sensitization associated gene-1) is safe? Since this has "uterine sensitization" in it, it seems like it may affect more than teeth! Just from a quick glance, this says its involved in pregnancy. > Given the remarkably tight restriction of its…
There's the possibility that localized suppression would be possible. Even if not, any scientists working on this will be well aware to check for potential health complications before human testing was even started.
Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#15The other one would be nice is synthetic gums for grafts. Far from teeth, should be one of the easier things.
Lot of research on that one. Just goes to show how lousy the development part of R&D is these days.
Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#16I hope someone works on recovering UOX (Urate Oxidase)[1] gene resurrection. It disappeared in one of our predessors making us prone to gout and excessive fat deposition[2]. Recovering this gene will treat both at the same time.
Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#17Earlier quoted context omitted.
I know you're joking but theres actually people who would pray for a treatment exactly like this. The elderly in particular. Over time all your teeth go. When I'm 60 I wouldnt mind them just ripping them all out if I could regrow them in 3 months.
Wouldn't they fall out like baby teeth do if new teeth grow under to push them out?
Great question, that might be even better.
Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#18Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#19I hope someone works on recovering UOX (Urate Oxidase)[1] gene resurrection. It disappeared in one of our predessors making us prone to gout and excessive fat deposition[2]. Recovering this gene will treat both at the same time. [1] https://www.genecards.org/cgi-bin/carddisp.pl?gene=UOX [2] https://www.nature.com/articles/s41366-019-0487-9
I found the Slate Star Codex article about uric acid interesting [1]. The bit about this gene:
> About ten million years ago, the common ancestor of apes and humans got a mutation that broke uricase, causing uric acid levels to rise. The mutation spread very quickly, suggesting that evolution _really_ wanted primates to have lots of uric acid for some reason. Since discovering this, scientists have been trying to figure out exactly what that reason was, with most people thinking it’s probably an antioxidant or neuroprotectant or something else helpful if you’re trying to evolve giant brains.
[1] https://slatestarcodex.com/2020/04/27/give-yourself-gout-for...
Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study
#20The article linked says it causes new teeth to grow in rats and ferrets, and that pugs and dogs are next. It doesn't however talk about targeting that growth to a particular place.
Just pull all teeth and let them regrow at the same time, of course. Next!
Really don't want to go through the process of having four impacted wisdom teeth removed again.