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Mouse studies show gene therapy can cause big drop in latent herpes infections

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Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#61

Post by inglor_cz »

wnevets wrote: post #4
RcouF1uZ4gsC wrote: post #2

.. In mice. It is unknown if it will work in humans. In addition, what are the long term consequences of causing multiple DNA cuts in nerve cells that the DNA repair mechanism cannot repair? There is still a very long, long way to go.

>DNA cuts in nerve cells that the DNA repair mechanism cannot repair If I read the article correctly the "cuts" are made to the DNA of the virus, not the nerve cell itself. [1] [1] The hidden herpes viruses are disabled by an injection that tracks down infected nerve cells and induces them to make special gene-cutting enzymes, which work like a molecular scissors, to slash viral genes in specific places. Much of the…

Basically, you want the cuts to only happen where they should. Without so-called "off target" edits, undesirable changes elsewhere.

We are becoming better with the molecular scissors, but 100 percent accuracy is AFAIK not there yet.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#62

Post by frongpik »

feralimal wrote: post #48

Hurrah for science! Hurrah for gene therapy! We are finally able to match God in creativity, and even improve the design! God/Nature was never that good anyway, we can give ourselves special powers now. Science ethics committees have discussed this, and they say its fine - we've had that discussion! Release the beast. Its not like my code is isn't perfect - I thrive when I barely have a handle on what a complicated f…

If we go into theology, then the nature is just a playground and the human body is just a complicated mechanism that a soul attaches to temporarily.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#63

Post by call_me_dana »

mrtesthah wrote: post #60
feralimal wrote: post #54

Earlier quoted context omitted.

Absolutely - we should do this everywhere! We should mandate in fact. Make sure that babies, the elderly, everyone have to get say, 'RNA' vaccines. Brilliant idea! What could go wrong? Nothing.

Do you think that mRNA vaccines work on a fundamentally different mechanism than any other vaccine developed in the last 70 years? They don’t. ‘What could go wrong?’ That’s an incredibly insulting perspective to take toward medical researchers who dedicate their entire careers to answering such questions.

They actually do. But your definition of “fundamentally different” may be fundamentally different than mine.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#64

Post by call_me_dana »

Traubenfuchs wrote: post #50
feralimal wrote: post #48

Hurrah for science! Hurrah for gene therapy! We are finally able to match God in creativity, and even improve the design! God/Nature was never that good anyway, we can give ourselves special powers now. Science ethics committees have discussed this, and they say its fine - we've had that discussion! Release the beast. Its not like my code is isn't perfect - I thrive when I barely have a handle on what a complicated f…

Taking charge of our evolution / genetics has always been humanities future and there is absolutely nothing wrong with eradicating disease and optimizing us however we see fit.

“Always” as in when statements like that starting appearing what, 50 years ago?

So... not always.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#65

Post by call_me_dana »

hannob wrote: post #46
tijuco2 wrote: post #10

What bothers me is that every single good news coming from science has the same old "but". >It will still take a long time before these experiments lead to the first human trials And we'll never hear from them again. You betcha!

It's often the case. It's not always the case. I remember the stories during the summer. "mRNA is promising, but there never was an mRNA vaccine that made it to the market. Nobody knows if it'll work." Well, it does work. Amazingly so.

And for the hundreds that have died from them already? I mean, not died from them. I mean died days to weeks after. They’re uhm, completely unrelated!

Would their families also agree that they work amazingly so?

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#66

Post by mrtesthah »

call_me_dana wrote: post #63
mrtesthah wrote: post #60

Earlier quoted context omitted.

Do you think that mRNA vaccines work on a fundamentally different mechanism than any other vaccine developed in the last 70 years? They don’t. ‘What could go wrong?’ That’s an incredibly insulting perspective to take toward medical researchers who dedicate their entire careers to answering such questions.

They actually do. But your definition of “fundamentally different” may be fundamentally different than mine.

Your immune system learns how to recognize a foreign antigen. The fact that your muscle cells' ribosomes are temporarily instructed to produce said antigenic proteins is immaterial to the fundamental mechanism of immunity. The mRNA stays in the cytoplasm and is not carried into the cell nucleus; it has no opportunity to affect the genome. The onus is on you here to present peer-reviewed evidence to the contrary.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#67

Post by call_me_dana »

mrtesthah wrote: post #66
call_me_dana wrote: post #63

Earlier quoted context omitted.

They actually do. But your definition of “fundamentally different” may be fundamentally different than mine.

Your immune system learns how to recognize a foreign antigen. The fact that your muscle cells' ribosomes are temporarily instructed to produce said antigenic proteins is immaterial to the fundamental mechanism of immunity. The mRNA stays in the cytoplasm and is not carried into the cell nucleus; it has no opportunity to affect the genome. The onus is on you here to present peer-reviewed evidence to the contrary.

No, mine is the accepted view and has been for years. Being that you are bringing a completely new outlook to the vaccination process, the onus is on you to provide evidence.

Anyone else who’s reading this, take note of what they did here. Say that mRNA gene therapy is the same fundamentally as traditional vaccines which is absolutely not the case. Then attempting to make the person espousing the traditional view provide evidence of the accepted fact. Liars like this need to be called out. They are NOT the same.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#68

Post by jpxk »

henearkr wrote: post #41
jpxk wrote: post #36

My understanding is that herpes (both HSV1 and HSV2) are not actually bad but have enormous social stigma, which is the main problem. I wonder what can be done to address that, as an alternative strategy.

They are actually bad, with a risk of chronic latent infection that could extend to deeper in the brain, and also a strongly suspected link with the (still unknown) cause of Alzheimer's.

You're right, I forgot about that connection.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#69

Post by pertymcpert »

call_me_dana wrote: post #65
hannob wrote: post #46

Earlier quoted context omitted.

It's often the case. It's not always the case. I remember the stories during the summer. "mRNA is promising, but there never was an mRNA vaccine that made it to the market. Nobody knows if it'll work." Well, it does work. Amazingly so.

And for the hundreds that have died from them already? I mean, not died from them . I mean died days to weeks after. They’re uhm, completely unrelated! Would their families also agree that they work amazingly so?

What are you on about? The vaccines haven’t killed anyone.

Re: Mouse studies show gene therapy can cause big drop in latent herpes infections

#70

Post by call_me_dana »

pertymcpert wrote: post #69
call_me_dana wrote: post #65

Earlier quoted context omitted.

And for the hundreds that have died from them already? I mean, not died from them . I mean died days to weeks after. They’re uhm, completely unrelated! Would their families also agree that they work amazingly so?

What are you on about? The vaccines haven’t killed anyone.

Huh? Here’s one report out of thousands

https://www.wric.com/health/coronavirus/man-in-70s-collapses...

So you can stop saying that now.

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