Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Moderna is announcing three new vaccine programs

investors.modernatx.com

Post reply on HN
Print view View original

231–236 of 236 posts

Re: Moderna is announcing three new vaccine programs

#231

Post by monopoledance »

henearkr wrote: post #229
monopoledance wrote: post #205

Earlier quoted context omitted.

I don't know if you can read the article apart from the abstract, so just in case: It proposes the idea for the mechanism of vitamin D supplementation to better certain conditions in the short term, but worsen health long term, by acting as a immune suppressant similar to other steroids. Here are some excerpts: > "Consequently, if patients with autoimmune disease succeed in killing bacteria associated with their dise…

Thanks, but I read the article, and my enthusiasm is justified. Because thus vitamin D would be a great solution against autoimmune diseases, among which are a lot of the cases under the umbrella Chronic Lyme Disease (it is supposed that the borreliosis can provoke an autoimmune dysfunction that continues beyond the disappearance of the bacteria). A lot of cases of chronic fatigue would be treated by vitamin D, which…

But they argue, it will make things worse and promote bacterial spread and growth...

They say the VD supplementation is comparable to steroid treatment. I don't see what's to be enthusiastic about, tbh.

Re: Moderna is announcing three new vaccine programs

#232

Post by henearkr »

monopoledance wrote: post #231
henearkr wrote: post #229

Earlier quoted context omitted.

Thanks, but I read the article, and my enthusiasm is justified. Because thus vitamin D would be a great solution against autoimmune diseases, among which are a lot of the cases under the umbrella Chronic Lyme Disease (it is supposed that the borreliosis can provoke an autoimmune dysfunction that continues beyond the disappearance of the bacteria). A lot of cases of chronic fatigue would be treated by vitamin D, which…

But they argue, it will make things worse and promote bacterial spread and growth... They say the VD supplementation is comparable to steroid treatment. I don't see what's to be enthusiastic about, tbh.

In the case where there are still Borrelia bacteria you're true, but if it can be checked that the intruders have vanished (which is the case in most cases of difficult to treat CLD or CF) then it should not pose any problem.

In the case where the Borrelia are just hiding and in a latent state, then all is a question of comparating the dynamics of the two sides: the time required by the Borrelia to wake up and proliferate, vs the time required by the vitamin D to reduce the autoimmunity to the point where the body is again desensitized about itself.

A short treatment of vitamin D would be sufficient to cure the immune problem and not long enough to allow the bacteria to take over. (Hypothetically. This is just a possibility and has to be researched, but this is exactly why I am enthusiastic.)

Also, contrary to steroidal treatment, vitamin D bolsters a part of the immunity (lymphocytes T), even if it dampens an other part. So, it would restore a balance which is lost in case of defective aquiered immunity.

Re: Moderna is announcing three new vaccine programs

#233

Post by dillondoyle »

valarauko wrote: post #224
dillondoyle wrote: post #219

Earlier quoted context omitted.

I have the DVDs too. It's worth the lower quality just for the music. Some of the most powerful scenes are deeply tied to the nusic for me, dancing at prom, Brian's bowling, the first episode, so many more - the replacement 'music' they hacked together is horrible too... Wow i didn't know the cellular aging part thank you. Do you have anymore info? I'm on it (or was when I could actually be around humans ;( ) The big…

The music on the show deeply influenced my musical tastes for at least a decade. The most moving scene for me personally was Brian bicycling by himself (S04E14) - for the longest time I would get weepy just thinking about it, and how it seemed to reflect where my own life was at the time. The music really tied it together - Wonderful Life by Colin Vearncombe. The cellular aging - it's something I discovered recently…

thanks!

HN is amazing sometimes ;)

I was 17/18 just becoming independent in college when I discovered the show and it gave me so much confidence.

'No excuses. No apologies. No Regrets", "F*ck em all", or Justin's self actualizing speech to his therapist and mom that I won't repeat here lol.

Yeah Gilead will reimburse all the copay. I guess so they can charge insurance/government an insane amount. Which is passed along to us anyways...

I think it was like $2000 out of pocket for me for 3 month supply. and i have really really good insurance.

Yeah the one dating experience i have had in covid that actually progressed I used that short time frame dosing.

Though in normal times for most PrEP users it would seem impossible to schedule sex in advanced or too frequent to do that.

But still really good research on how effective these drugs are. maybe we'll get more research into short term PeP - though i think that's a different drug combo.

Re: Moderna is announcing three new vaccine programs

#234

Post by valarauko »

dillondoyle wrote: post #233
valarauko wrote: post #224

Earlier quoted context omitted.

The music on the show deeply influenced my musical tastes for at least a decade. The most moving scene for me personally was Brian bicycling by himself (S04E14) - for the longest time I would get weepy just thinking about it, and how it seemed to reflect where my own life was at the time. The music really tied it together - Wonderful Life by Colin Vearncombe. The cellular aging - it's something I discovered recently…

thanks! HN is amazing sometimes ;) I was 17/18 just becoming independent in college when I discovered the show and it gave me so much confidence. 'No excuses. No apologies. No Regrets", "F*ck em all", or Justin's self actualizing speech to his therapist and mom that I won't repeat here lol. Yeah Gilead will reimburse all the copay. I guess so they can charge insurance/government an insane amount. Which is passed alon…

Any idea if Descovy is similarly reimbursed by Gilead?

Re: Moderna is announcing three new vaccine programs

#235

Post by dillondoyle »

valarauko wrote: post #234
dillondoyle wrote: post #233

Earlier quoted context omitted.

thanks! HN is amazing sometimes ;) I was 17/18 just becoming independent in college when I discovered the show and it gave me so much confidence. 'No excuses. No apologies. No Regrets", "F*ck em all", or Justin's self actualizing speech to his therapist and mom that I won't repeat here lol. Yeah Gilead will reimburse all the copay. I guess so they can charge insurance/government an insane amount. Which is passed alon…

Any idea if Descovy is similarly reimbursed by Gilead?

maybe: https://www.descovy.com/treatment/co-pay-assistance

Re: Moderna is announcing three new vaccine programs

#236

Post by ed_balls »

woleium wrote: post #230
ed_balls wrote: post #207

Earlier quoted context omitted.

It seems we need to cull a lot of bats.

that actually makes transmission more likely. more culling means less comptition for food so more reproduction, which leads to a larger number of juvenile bats. Additionally, bats eat insects including mosquitos that cause maleria and they also pollinate fruit.

not really https://www.bbc.com/news/world-us-canada-53856776
Post reply on HN