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No one who got Moderna's vaccine in trial developed severe Covid-19

sciencemag.org

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Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#51

Post by smt88 »

SomeoneFromCA wrote: post #14
ck2 wrote: post #8

Yeah but imagine being dumb enough to get infected and very sick over the next month before you can get both shots next year. Because there are going to be thousands, maybe millions who do that in the USA alone for no good reason.

They are failing the Marshmallow test.

You are accidentally correct. You seem to think the Marshmallow Test is a test of willpower.

That interpretation is debunked. It is actually a test of poverty.

https://www.smithsonianmag.com/smart-news/new-research-marsh...

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#52

Post by School-Cotton »

dashundchen wrote: post #40
alfon wrote: post #16

Earlier quoted context omitted.

Not everyone has the privilege of working from home while they get their meal preps comfortably delivered to their doorstep.

No, but there have been plenty of people in the US gathering unnecessarily, not for essential work, but in large groups for Halloween parties and bars, with extended family and older relatives for Thanksgiving, and are likely to gather multiple times for Christmas once again. Now unsurprisingly the pandemic is out of control, hospitals in many regions are overcapacity and the overworked essential healthcare workers m…

Social interaction is essential for humans, not optional.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#53

Post by iguy »

faitswulff wrote: post #31
delfinom wrote: post #24

Earlier quoted context omitted.

Sadly from the manufacturing process description alone, we are going to be decades away from when it's actually ...not a few million dollars per individual to treat.

An individually tailored cancer treatment is already available in the form of the CAR-T therapies, which might give an indication of how expensive it’ll be - you were pretty much right on the dot, since each treatment in a course of treatments is estimated at $375,000.

What is this money spent on? Is it a real cost per dose, or just a made-up number for something made in a research lab?

Maybe another way to ask is: On the scale from 400k of white-shoe lawyer-hours, to 400k of custom 7nm silicon-etching, where should I mentally place this? The former isn't going to budge, the latter will cost pennies in a generation's time.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#55

Post by nkjoep »

whb07 wrote: post #54

Hurray for a vaccine that is > 90% effective on a disease that for those who get it have a > 99% survival rate. Bring on the new overlords.

I guess survival rate means a different thing from side effects.

I would be still cautious with that statement and not underestimate it.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#56

Post by amurale »

lultimouomo wrote: post #45
amurale wrote: post #36

> No one developed severe Covid-19 > No one developed severe adverse effects (yet) There is a reason vaccine trials normally take several years. I'll wait until we're a few years into phase IV trials, thankyouverymuch.

Honest question: would you wait if there was a pact to the effect that either everyone takes the vaccine, or no one does? Because obviously not getting vaccinated when everybody else does is almost always the best choice game-theoretically speaking; it doesn't really say anything on the vaccine (it may say more on the civic sense of the individual).

Let's see... it's a calculus of death vs potential long term adverse effect:

P(death) I'd take the vaccine in a heartbeat, long term effects and all, if P(death) was 10% or higher.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#57

Post by NicoJuicy »

Antimateri4 wrote: post #6
inglor_cz wrote: post #2

RNA vaccines have a huge potential in treating cancer as well. Basically, you can whip up a personalized vaccine which wakes the immune system up to the fact that it has a growing tumor on its hands. So far, the success rate is very far from 100 per cent, but the therapy sometimes works even in patients with severe late stage metastatized cancer and, in all likelihood, we will learn how to use it better in coming yea…

Yes i read some interesting article aswell regarding mRNA vaccines, but from my understanting mRNA vaccine aren't yet tested in humans right? Only animals or am i mistaken? EDIT: what my question is: is there another mRNA type vaccine out there fully developed (i'm not suggesting that they are bad!)? EDIT2: Guys, i will never ask question again in here. Begin downvoted for a genuine question.

You're probably being downvoted because this information is easily looked up.

https://en.m.wikipedia.org/wiki/RNA_vaccine

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#58

Post by ed25519FUUU »

blhack wrote: post #48

Does anybody have a good link for a layman's overview of how mRNA vaccines work? Lot's of nervousness from people around this, and would love to be able to help quell some of that.

Edit: I do plan to get the vaccine, but as a software engineer I know beta versions usually have the most “bugs” — and I have the health privilege to be in the back of the line so I will!

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#59

Post by SpicyLemonZest »

blackmagicjs wrote: post #38
mchusma wrote: post #19

FDA says Dec 17 meeting to discuss. This contradicts some earlier opinions that the reason the FDA was taking so long to review Pfizer (Dec 10 scheduled date) was that they were planning to review 2-3 candidates together. For context, scheduling the meeting to review the candidates is running at 5-10% of the development time for these vaccines. 20M vaccines represent about 1/3 the elderly population in the US, there…

There may be other ways to reduce risk if you belong to the at risk population, though. Those statistics all have to be taken with a grain of salt. Like if it says "x% of some population will die from some thing", it could mean "x% in the population tend to be reckless" (like "x% of people under 30 will die from base jumping", but it is easy to avoid by not doing base jumping). In the case of Covid, perhaps not livin…

There may be in general, but in this case I don't think it's a factor. Something like 40% of deaths have happened in nursing homes, where residents don't have much agency to reduce their individual risk.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#60

Post by throwawaysea »

ghaff wrote: post #30
mchusma wrote: post #19

FDA says Dec 17 meeting to discuss. This contradicts some earlier opinions that the reason the FDA was taking so long to review Pfizer (Dec 10 scheduled date) was that they were planning to review 2-3 candidates together. For context, scheduling the meeting to review the candidates is running at 5-10% of the development time for these vaccines. 20M vaccines represent about 1/3 the elderly population in the US, there…

>Note: I think the bar for requiring a vaccination can/should definitely be higher than the bar to lift a total ban on a vaccine. It's unlikely in the US that the federal government could require vaccination. States maybe could but only because of very old case law that might well not stand up today. Of course, private workplaces, schools, government offices, airlines, etc. could to the degree that it might be quite…

> States maybe could but only because of very old case law that might well not stand up today. Of course, private workplaces, schools, government offices, airlines, etc. could to the degree that it might be quite difficult at some point to refuse.

States probably can compel people to take it, considering some already require it for use of public services like schools. I’m guessing private companies can do whatever they want as long as they avoid running into disability law. I think this is a problem though - as a matter of principle, bodily autonomy is sacrosanct. Citizens who are forced to give up bodily autonomy to use basic services they can’t reasonably avoid (roads, public transportation, schools, etc) simply don’t have basic freedoms in my view.

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