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No one who got Moderna's vaccine in trial developed severe Covid-19

sciencemag.org

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Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#31

Post by faitswulff »

delfinom wrote: post #24
inglor_cz wrote: post #2

RNA vaccines have a huge potential in treating cancer as well. Basically, you can whip up a personalized vaccine which wakes the immune system up to the fact that it has a growing tumor on its hands. So far, the success rate is very far from 100 per cent, but the therapy sometimes works even in patients with severe late stage metastatized cancer and, in all likelihood, we will learn how to use it better in coming yea…

Sadly from the manufacturing process description alone, we are going to be decades away from when it's actually ...not a few million dollars per individual to treat.

An individually tailored cancer treatment is already available in the form of the CAR-T therapies, which might give an indication of how expensive it’ll be - you were pretty much right on the dot, since each treatment in a course of treatments is estimated at $375,000.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#32

Post by ed25519FUUU »

delfinom wrote: post #24
inglor_cz wrote: post #2

RNA vaccines have a huge potential in treating cancer as well. Basically, you can whip up a personalized vaccine which wakes the immune system up to the fact that it has a growing tumor on its hands. So far, the success rate is very far from 100 per cent, but the therapy sometimes works even in patients with severe late stage metastatized cancer and, in all likelihood, we will learn how to use it better in coming yea…

Sadly from the manufacturing process description alone, we are going to be decades away from when it's actually ...not a few million dollars per individual to treat.

If it cures late stage cancer a few million per treatment would actually be a bargain.

Edit: I have no clue why people would rather something not exist than for something to exist but for it to be too expensive.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#33

Post by ulfw »

IronRanger wrote: post #21

What was the age profile of the trial? If you fill it with healthy people under 50 during Summer you would expect the same results with a placebo, given the profile of the virus.

They would never be that dumb to do that. In fact "The Phase 3 COVE study was designed in collaboration with the FDA and NIH to evaluate Americans at the highest risk of severe COVID-19 disease. As of today, the COVE study includes more than 7,000 Americans over the age of 65"

https://investors.modernatx.com/news-releases/news-release-d...

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#34

Post by mrmonkeyman »

ed25519FUUU wrote: post #32
delfinom wrote: post #24

Earlier quoted context omitted.

Sadly from the manufacturing process description alone, we are going to be decades away from when it's actually ...not a few million dollars per individual to treat.

If it cures late stage cancer a few million per treatment would actually be a bargain. Edit: I have no clue why people would rather something not exist than for something to exist but for it to be too expensive.

That depends on the individual..

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#35

Post by [deleted] »

mchusma wrote: post #19

FDA says Dec 17 meeting to discuss. This contradicts some earlier opinions that the reason the FDA was taking so long to review Pfizer (Dec 10 scheduled date) was that they were planning to review 2-3 candidates together. For context, scheduling the meeting to review the candidates is running at 5-10% of the development time for these vaccines. 20M vaccines represent about 1/3 the elderly population in the US, there…

[deleted]

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#37

Post by renewiltord »

IronRanger wrote: post #21

What was the age profile of the trial? If you fill it with healthy people under 50 during Summer you would expect the same results with a placebo, given the profile of the virus.

Here's a starting point for your search https://investors.modernatx.com/static-files/34f97bb2-d89a-4...

I've found the answer starting from there. Good luck.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#38

Post by blackmagicjs »

mchusma wrote: post #19

FDA says Dec 17 meeting to discuss. This contradicts some earlier opinions that the reason the FDA was taking so long to review Pfizer (Dec 10 scheduled date) was that they were planning to review 2-3 candidates together. For context, scheduling the meeting to review the candidates is running at 5-10% of the development time for these vaccines. 20M vaccines represent about 1/3 the elderly population in the US, there…

There may be other ways to reduce risk if you belong to the at risk population, though.

Those statistics all have to be taken with a grain of salt. Like if it says "x% of some population will die from some thing", it could mean "x% in the population tend to be reckless" (like "x% of people under 30 will die from base jumping", but it is easy to avoid by not doing base jumping).

In the case of Covid, perhaps not living in an old people's home (in March) could improve your odds by a lot.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#40

Post by dashundchen »

alfon wrote: post #16
ck2 wrote: post #8

Yeah but imagine being dumb enough to get infected and very sick over the next month before you can get both shots next year. Because there are going to be thousands, maybe millions who do that in the USA alone for no good reason.

Not everyone has the privilege of working from home while they get their meal preps comfortably delivered to their doorstep.

No, but there have been plenty of people in the US gathering unnecessarily, not for essential work, but in large groups for Halloween parties and bars, with extended family and older relatives for Thanksgiving, and are likely to gather multiple times for Christmas once again.

Now unsurprisingly the pandemic is out of control, hospitals in many regions are overcapacity and the overworked essential healthcare workers mentioned are sending patients hundreds of miles away to the nearest available bed.

These gatherings are selfish and completely avoidable. If these multiple vaccine candidates are as promising as they are sounding, people should hold off a few more months on social events until this vaccine starts getting deployed to the highest risk crowd.

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