What was the age profile of the trial? If you fill it with healthy people under 50 during Summer you would expect the same results with a placebo, given the profile of the virus.
No one who got Moderna's vaccine in trial developed severe Covid-19
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Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#22Wonder what the trial exclusion criteria was...it’s not referenced in this article.
Can read all of them in their published protocol at https://www.modernatx.com/sites/default/files/mRNA-1273-P301... under section 5.2.
Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#23Wonder what the trial exclusion criteria was...it’s not referenced in this article.
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Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#24RNA vaccines have a huge potential in treating cancer as well. Basically, you can whip up a personalized vaccine which wakes the immune system up to the fact that it has a growing tumor on its hands. So far, the success rate is very far from 100 per cent, but the therapy sometimes works even in patients with severe late stage metastatized cancer and, in all likelihood, we will learn how to use it better in coming yea…
Sadly from the manufacturing process description alone, we are going to be decades away from when it's actually ...not a few million dollars per individual to treat.
Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#25>>> Anti-vaxxers immediately jump on any report of possible adverse events in a vaccine trial (which are thoroughly investigated, of course). >>> Let’s spare a thought today for the person who signed up for the Moderna vaccine trial, received two placebo shots and died of covid19. https://twitter.com/kakape/status/1333401133260419072 --- edit: Please explain the downvotes. The vaccine volunteer would be alive if he w…
I think this might have flown better if you had included the first half of the tweet: Anti-vaxxers immediately jump on any report of possible adverse events in a vaccine trial (which are thoroughly investigated, of course).
That really puts the second half in context.
Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#26What was the age profile of the trial? If you fill it with healthy people under 50 during Summer you would expect the same results with a placebo, given the profile of the virus.
That would be a likely outcome even under the null hypothesis in a phase II trial, but, for a 30,000 person efficacy trial, I wouldn't be so quick to offhandedly dismiss the assertion that that's a significant result.
Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#27>>> Anti-vaxxers immediately jump on any report of possible adverse events in a vaccine trial (which are thoroughly investigated, of course). >>> Let’s spare a thought today for the person who signed up for the Moderna vaccine trial, received two placebo shots and died of covid19. https://twitter.com/kakape/status/1333401133260419072 --- edit: Please explain the downvotes. The vaccine volunteer would be alive if he w…
I think this might have flown better if you had included the first half of the tweet: Anti-vaxxers immediately jump on any report of possible adverse events in a vaccine trial (which are thoroughly investigated, of course). That really puts the second half in context.
interesting, I've added the full tweet.
Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#28>>> Anti-vaxxers immediately jump on any report of possible adverse events in a vaccine trial (which are thoroughly investigated, of course). >>> Let’s spare a thought today for the person who signed up for the Moderna vaccine trial, received two placebo shots and died of covid19. https://twitter.com/kakape/status/1333401133260419072 --- edit: Please explain the downvotes. The vaccine volunteer would be alive if he w…
I think the downvotes are from people assuming you're denouncing the placebo portion of a randomized clinical trial? Maybe indicate otherwise? (Or explicitly state it if I'm wrong). All of those that died during clinical trials deserve respect for signing up and helping us advance the medicine. Their death is a statistic, but not in the Stalin quote sense! It's a statistic that helped us find the treatment that will…
not sure what you mean "denouncing the placebo portion of a randomized clinical trial" but I'm going to move on with my life and accept my -4 reputation :)
Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#29Yeah but imagine being dumb enough to get infected and very sick over the next month before you can get both shots next year. Because there are going to be thousands, maybe millions who do that in the USA alone for no good reason.
Dumb people like teachers, doctors, nurses, first responders, the infirm, grocery stockers? Dumb people that have to work to pay their rent, mortgage, put food on the table? I know there are a lot of idiot anti-maskers running around, but being dumb is not a prerequisite to catching covid. Not everyone has the luxury of working from home.
Re: No one who got Moderna's vaccine in trial developed severe Covid-19
#30FDA says Dec 17 meeting to discuss. This contradicts some earlier opinions that the reason the FDA was taking so long to review Pfizer (Dec 10 scheduled date) was that they were planning to review 2-3 candidates together. For context, scheduling the meeting to review the candidates is running at 5-10% of the development time for these vaccines. 20M vaccines represent about 1/3 the elderly population in the US, there…
>Note: I think the bar for requiring a vaccination can/should definitely be higher than the bar to lift a total ban on a vaccine.
It's unlikely in the US that the federal government could require vaccination. States maybe could but only because of very old case law that might well not stand up today. Of course, private workplaces, schools, government offices, airlines, etc. could to the degree that it might be quite difficult at some point to refuse.
To your broader point, if a roll the dice strategy backfired, you could not only have had dead people but you'd basically make vaccine development untenable both for this and probably other diseases.