111–120 of 401 posts
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A daily dose of 2000-4000 is enough and is very safe. 42% of Americans are deficient, much more the darker your skin is. https://www.healthline.com/nutrition/vitamin-d-deficiency-sy...
Could help explain why COVID-19 is much more severe (on average) if you’re black...
Noteworthy that this is in combination with anti-viral drugs at hospital admission: hydroxychloroquine (400 mg every 12 hours on the first day, and 200 mg every 12 hours for the following 5 days), azithromycin (500 mg orally for 5 days). Regardless, I'm going to assume this means being outside and getting sun is good for me.
To be clear, all patients received these supplemental drugs, as at the time they were considered the best standard of care. (Also to be clear: they're not anti-virals.) Of the 75 patients in the trial, 50 people received additionally Vitamin D3 supplementation (in the form of calcifediol), and 25 did not. Notably, though, diabetes and high blood pressure were substantially more frequent in the control group, which ar…
How did this happen? Just bad luck with randomization?
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To be clear, all patients received these supplemental drugs, as at the time they were considered the best standard of care. (Also to be clear: they're not anti-virals.) Of the 75 patients in the trial, 50 people received additionally Vitamin D3 supplementation (in the form of calcifediol), and 25 did not. Notably, though, diabetes and high blood pressure were substantially more frequent in the control group, which ar…
> Notably, though, diabetes and high blood pressure were substantially more frequent in the control group How did this happen? Just bad luck with randomization?
Best case scenario: Less dead people.
Worst case scenario: We all have healthier bones.
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Azithromycin is a common antibiotic, not an anti-viral drug. This is an important distinction. Also hydroxychloroquine is an anti-malarial drug, which is also not an anti-viral.
Hydroxychloroquine is a zinc ionophore which helps zinc get into the cells in your lungs and slows the viral replication. It was not designed to be used this way, it just happens to work. This is mostly useful before your viral load is high. Same goes for Quercetin, also a zinc ionophore. They are good proactive measures to slow down the viral transcription before you reach a critical stage. It won't help everyone, e…
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By going outside you are likely to spread the virus.
Not really. Super-spreader events outside are essentially unheard of - both the sunlight & plentiful air make transmission much harder. Don't get up-close with crowds of strangers, sure, but growing evidence suggests 6' outdoors is safer than 20'-plus in any enclosed, recirculating-air indoors. Now, if you go outside in order to enter some other indoors, with people who may be infected, you're creating risks.
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"Parallel" generally means that different groups of patients receive different treatments. The opposite is a within-patient study, where all patients get all treatments over time (possibly varying the order to prevent order effects). "Open-label" generally means "not blind at all." Basically, the patient knows what treatment is being administered. "Double-masked" is usually synonymous with "double-blind," because "ma…
>"Double-masked" is usually synonymous with "double-blind," because "masking" sounds less violent than "blinding." This is literally the first time I've heard of "double-blind" being interpreted this way.
- https://link.springer.com/referenceworkentry/10.1007%2F978-3...
- https://az.research.umich.edu/medschool/glossary/double-mask...
- https://aidsinfo.nih.gov/understanding-hiv-aids/glossary/211...
Too many powerful people are heavily invested in the belief that there is no treatment for it.
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I got one that is still in effect in Michigan- "Gyms are closed" (but bars and casinos are open) A virus that kills old and _obese_ people, and you are shutting down the gym? If anything I hope Coronavirus shifts politicians from business leaders to scientists.
Weight gain and loss is simple physics. If you want to reduce obesity, focus on the dietary input. Virtually nobody is active enough to burn the extreme number of excess calories consumed that leads to obesity and the maintenance of obesity.
Good on you, Spain. A study like this could never take place in the USA :( Too many powerful people are heavily invested in the belief that there is no treatment for it.