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The dual PhD problem of today’s startups

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Re: The dual PhD problem of today’s startups

#112

Earlier quoted context omitted.

Judging by the lack of coherency / relevance of the profile's other replies, I'm guessing it's a bot whose model someone's attempting to train on HN comments.

A model that has coherency over multiple paragraphs? I don't think that's currently possible - but if I'm wrong about that I'd love a link to a study or a library if you have one. Natural language processing is something I'm very interested in.

...did you miss the entire GPT3 hype wave?

Re: The dual PhD problem of today’s startups

#113
post #75
post #40

Earlier quoted context omitted.

SBIR funding is critical for hard science ventures early on. It's also a good indicator to future investors of potential hard science projects that a panel of experts in the area has reviewed and approved government funding for the idea, and the team is at least decently competent to meet the milestones of the SBIR. This helped Ginkgo Bioworks before they received more than half a billion in private investment.

There's decently large amounts of money to be had with SBIRs, but they are a moving target--you end up stitching together many different smaller projects to slowly ping pong your way to the end goal. Of course they're also very slow to apply, decide, reapply, etc

With hard science ventures that sometimes have a hard time findng the 'killer app' for the technology, I think the experience and learning from ping ponging around is a feature. Yes, startups need to plan for the long and uncertain apply-decide-reapply cycle

Re: The dual PhD problem of today’s startups

#114
post #75

Earlier quoted context omitted.

There's decently large amounts of money to be had with SBIRs, but they are a moving target--you end up stitching together many different smaller projects to slowly ping pong your way to the end goal. Of course they're also very slow to apply, decide, reapply, etc

And consume massive amounts of a small startup team's highest skill expertise for weeks to have any chance of getting. And have a known death valley and cash flow issue unless you have other investment already. But they're a nice to have for sure. Just not enough to keep moving for long enough to get most hard tech startups funded.

I'd be interested in seeing citations for the known death valley. This is the second time I've heard this anecdote but have never seen the evidence.

Re: The dual PhD problem of today’s startups

#115
post #86

Earlier quoted context omitted.

If anyone asks you to do this, please make renting a Blueberry a condition of your participation.

Not chemistry experienced, and a quick internet search isn't doing the trick, but is a "Blueberry" some kind of mass spectrometer? How much would something like that rent for, or is it more of a "if you have to ask" situation?

It was actually a reference to the TV show Psych, whose character Burton Guster (and his many aliases) drove a bright blue Toyota Matrix hatchback affectionately referred to as "The Blueberry".

Re: The dual PhD problem of today’s startups

#117
post #87

So how is R&D being funded in China? China has government-funded everything. How's that working out?

China has a program called "1,000 Talents" to steal everything from the US that isn't nailed down. Hence the recent arrests.

https://en.wikipedia.org/wiki/Thousand_Talents_Plan

Re: The dual PhD problem of today’s startups

#118
post #114

Earlier quoted context omitted.

And consume massive amounts of a small startup team's highest skill expertise for weeks to have any chance of getting. And have a known death valley and cash flow issue unless you have other investment already. But they're a nice to have for sure. Just not enough to keep moving for long enough to get most hard tech startups funded.

I'd be interested in seeing citations for the known death valley. This is the second time I've heard this anecdote but have never seen the evidence.

Oh, no one would probably bother to cite it because it's right there in the request for proposals in black and white and they explicitly talk about it repeatedly at the SBIR conferences.

You finish your phase 1 in 9 months to a year depending. Then you apply for phase 2 which takes 3-6 months to review and fund. That's the death valley I mean, the lag between finishing phase 1 and starting phase 2.

If you don't have non-grant funding by then, you're self-funding the company for six months of being strung along waiting for them to make a decision. It sucks, especially when VCs have no interest in funding projects that are as hard to understand as my stuff (catalysts and chemicals and machine learning) when they can just fund Uber for cats or whatever.

I'm too tired to keep trying for it, but at least people are finally starting to recognize that chemical manufacturing infrastructure is pretty critical and that we don't understand much of it at all and that if we want to use bio-sourced chemicals we need to really understand this at a global systems level an awful lot better.

But we won't, we'll just try to bolt on bio stuff to horrible legacy systems and make a marginal improvement instead of a generational breakthrough. But if anyone reading this happens to actually be working on this give me a ring... it's my passion in life to fix this because I see it as reducing energy consumption and also improving agriculture through improved ammonia production processes. I am just unable to work on it because of life. And I really don't want to start another company at this point.

Re: The dual PhD problem of today’s startups

#119
post #66

Earlier quoted context omitted.

Unfortunately large companies invest much less in longer-term research than they used to. Bell Labs was a thing ... once.

Bell Labs was funded by a government-sanctioned monopoly. Calling it a "corporate lab" is incredibly misleading, but popular among corporate lab types.

Many companies that did not have a sanctioned monopoly used to have significant investments in research labs; those investments have been scaled back drastically.

Re: The dual PhD problem of today’s startups

#120
Our hubris is rooted on our systems. We expect accelerating growth without bound. And, by Conway’s Law: “Any organization that designs a system (defined broadly) will produce a design whose structure is a copy of the organization's communication structure.” We have a social and economic system of Survival of the Fittest, which is loosely based on evolution. Evolution has killed 99.9% of the species that have every existed, and our systems do the same. My internal dialectic tells me that there’s three responses to this: 1) The metaphor is lost, and that the statement is “all over the place”, exemplifying the point of the article, that, we cannot communicate effectively outside of our limited understanding. That we cannot have new thought, in part because it cannot be clearly stated. 2) Full throated support for the system prevents us from being able to objectively question why were doing the things that we are doing, which is precisely what Conway’s Law is trying to state. 3) Having a understanding, but idealistic perception, of the world means not being able to do anything about it. Survival of the Fittest means that cooperation will be exploited, and definitely not reciprocated.

In order to find new ground, you may find yourself needing to do something truly out of the ordinary. Try holding board meetings in Swahili. Try “running your business” (which loses context given the next few words) without the concept of ownership or property. Seek sources of knowledge and wisdom outside of the scientific method, religion, business schools, political systems. Of course these would obviously fail (see 3 above) in the current system. We don’t tolerate failure. And we like to see out-of-the-box thinking fail because it further validates our existence systems. We may very well be at a maxima for social and economic development. The cost to try something new would be tremendous. We’re also disadvantaged that we have homogenized culture and thought. Even the simplest changes may require a step back that would be considered another dark age.

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