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The dual PhD problem of today’s startups

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Re: The dual PhD problem of today’s startups

#72
post #62

Earlier quoted context omitted.

This, 100%. The author says how difficult it is for multidisciplinary teams to come together when they don't understand each others skillsets--but the same applies to the investors themselves. When you start talking about these complicated ideas, there comes a point where unless the investor is involved in the industry they're investing in, they simply won't understand the true impact of it. My company is trying to r…

This is describing just one painful route up the mountain. There are other routes, which usually involve sucking it up, going and working at Wall St or SV for a couple years till you know the "right people" and they know/trust you. After that happens the type of conversations change drastically.

You’re doing it wrong. It’s about time and chemistry and knowing how to tell the story, even if it is in Yang Mills 5D

Re: The dual PhD problem of today’s startups

#73
post #47

Earlier quoted context omitted.

It's 1. But also, who can blame them. I've seen really stupid companies come out of biotech incubators, including one that was peddling a genetically modified probiotic whose concoction as designed is known to be ineffective pharmacologically (and an equivalent reformulation strategy is not known in their host species), and a company that demoed reconstituted mock vegan meringues that had residual trifluoroacetic aci…

We're kind of like Uber but instead of calling a car for yourself, you call a deadly pie for your enemies. Our drivers are incentivized by the rating system to operate with discretion that beats similar state-sanctioned programs. Launch flavors include Rhubarb, Almost Almond, and Death by Chocolate.

7 for effort

Re: The dual PhD problem of today’s startups

#74
post #40
post #25

The reason you don't see more startups in the hard sciences is not due to the lack of hybrid talent as this article surmises. It's because: 1 - VCs are reluctant to fund capital intensive startups that have time horizons for exits that are significantly longer than software based startups. 2 - The product lifecycle is so much longer, which makes it inherently much riskier. In many cases it can be years before you eve…

SBIR funding is critical for hard science ventures early on. It's also a good indicator to future investors of potential hard science projects that a panel of experts in the area has reviewed and approved government funding for the idea, and the team is at least decently competent to meet the milestones of the SBIR. This helped Ginkgo Bioworks before they received more than half a billion in private investment.

Or another avenue to abuse just to prove a point. That you could. Make ‘me pray and sweat, in fear for what you would do next.

Re: The dual PhD problem of today’s startups

#75
post #40
post #25

The reason you don't see more startups in the hard sciences is not due to the lack of hybrid talent as this article surmises. It's because: 1 - VCs are reluctant to fund capital intensive startups that have time horizons for exits that are significantly longer than software based startups. 2 - The product lifecycle is so much longer, which makes it inherently much riskier. In many cases it can be years before you eve…

SBIR funding is critical for hard science ventures early on. It's also a good indicator to future investors of potential hard science projects that a panel of experts in the area has reviewed and approved government funding for the idea, and the team is at least decently competent to meet the milestones of the SBIR. This helped Ginkgo Bioworks before they received more than half a billion in private investment.

There's decently large amounts of money to be had with SBIRs, but they are a moving target--you end up stitching together many different smaller projects to slowly ping pong your way to the end goal. Of course they're also very slow to apply, decide, reapply, etc

Re: The dual PhD problem of today’s startups

#76
This is an argument for the corporate research lab, where you have people on staff who know how to do things. Xerox PARC was able to build the first laser printer because they were in the same building as the people who worked on copier technology. So they had people who knew about photoconductors and paper feeding and getting the toner to stick to the right part of the paper.

Jack Kilby was able to make the first IC because he worked in a transistor factory.

Re: The dual PhD problem of today’s startups

#77
post #62

Earlier quoted context omitted.

This is describing just one painful route up the mountain. There are other routes, which usually involve sucking it up, going and working at Wall St or SV for a couple years till you know the "right people" and they know/trust you. After that happens the type of conversations change drastically.

You’re doing it wrong. It’s about time and chemistry and knowing how to tell the story, even if it is in Yang Mills 5D

What?

Re: The dual PhD problem of today’s startups

#78
post #77

Earlier quoted context omitted.

You’re doing it wrong. It’s about time and chemistry and knowing how to tell the story, even if it is in Yang Mills 5D

What?

Judging by the lack of coherency / relevance of the profile's other replies, I'm guessing it's a bot whose model someone's attempting to train on HN comments.

Re: The dual PhD problem of today’s startups

#79
post #25

The reason you don't see more startups in the hard sciences is not due to the lack of hybrid talent as this article surmises. It's because: 1 - VCs are reluctant to fund capital intensive startups that have time horizons for exits that are significantly longer than software based startups. 2 - The product lifecycle is so much longer, which makes it inherently much riskier. In many cases it can be years before you eve…

I agree with #1 in particular. However, there are always ways around these issues. Some solutions for founders: 1. Use an evergreen fund (such as many family funds) instead of traditional 10-year fund lifetime VC. They are specifically set up to harvest these sorts of opportunities. 2. Demonstrate commitment and operational efficiency. For example spend nontrivial amounts of time and funds on the project to reach relatively advanced stages before asking for outside investment. 3. Regulatory hedging (cross-border operations, and establishing facilities near borders) is one viable strategy.

Full disclosure: I run a nontrivial hardware startup seeking to define and dominate a greenfield segment and have used all three strategies in the last few years.

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