The dual PhD problem of today’s startups
111–120 of 126 posts
Re: The dual PhD problem of today’s startups
#112Earlier quoted context omitted.
Judging by the lack of coherency / relevance of the profile's other replies, I'm guessing it's a bot whose model someone's attempting to train on HN comments.
A model that has coherency over multiple paragraphs? I don't think that's currently possible - but if I'm wrong about that I'd love a link to a study or a library if you have one. Natural language processing is something I'm very interested in.
Re: The dual PhD problem of today’s startups
#113Earlier quoted context omitted.
SBIR funding is critical for hard science ventures early on. It's also a good indicator to future investors of potential hard science projects that a panel of experts in the area has reviewed and approved government funding for the idea, and the team is at least decently competent to meet the milestones of the SBIR. This helped Ginkgo Bioworks before they received more than half a billion in private investment.
There's decently large amounts of money to be had with SBIRs, but they are a moving target--you end up stitching together many different smaller projects to slowly ping pong your way to the end goal. Of course they're also very slow to apply, decide, reapply, etc
Re: The dual PhD problem of today’s startups
#114Earlier quoted context omitted.
There's decently large amounts of money to be had with SBIRs, but they are a moving target--you end up stitching together many different smaller projects to slowly ping pong your way to the end goal. Of course they're also very slow to apply, decide, reapply, etc
And consume massive amounts of a small startup team's highest skill expertise for weeks to have any chance of getting. And have a known death valley and cash flow issue unless you have other investment already. But they're a nice to have for sure. Just not enough to keep moving for long enough to get most hard tech startups funded.
Re: The dual PhD problem of today’s startups
#115Earlier quoted context omitted.
If anyone asks you to do this, please make renting a Blueberry a condition of your participation.
Not chemistry experienced, and a quick internet search isn't doing the trick, but is a "Blueberry" some kind of mass spectrometer? How much would something like that rent for, or is it more of a "if you have to ask" situation?
Re: The dual PhD problem of today’s startups
#116Things close the edge are risky. Things close to two edges are even more risky.
Risk isn't reduced by reward.
Re: The dual PhD problem of today’s startups
#117So how is R&D being funded in China? China has government-funded everything. How's that working out?
Re: The dual PhD problem of today’s startups
#118Earlier quoted context omitted.
And consume massive amounts of a small startup team's highest skill expertise for weeks to have any chance of getting. And have a known death valley and cash flow issue unless you have other investment already. But they're a nice to have for sure. Just not enough to keep moving for long enough to get most hard tech startups funded.
I'd be interested in seeing citations for the known death valley. This is the second time I've heard this anecdote but have never seen the evidence.
You finish your phase 1 in 9 months to a year depending. Then you apply for phase 2 which takes 3-6 months to review and fund. That's the death valley I mean, the lag between finishing phase 1 and starting phase 2.
If you don't have non-grant funding by then, you're self-funding the company for six months of being strung along waiting for them to make a decision. It sucks, especially when VCs have no interest in funding projects that are as hard to understand as my stuff (catalysts and chemicals and machine learning) when they can just fund Uber for cats or whatever.
I'm too tired to keep trying for it, but at least people are finally starting to recognize that chemical manufacturing infrastructure is pretty critical and that we don't understand much of it at all and that if we want to use bio-sourced chemicals we need to really understand this at a global systems level an awful lot better.
But we won't, we'll just try to bolt on bio stuff to horrible legacy systems and make a marginal improvement instead of a generational breakthrough. But if anyone reading this happens to actually be working on this give me a ring... it's my passion in life to fix this because I see it as reducing energy consumption and also improving agriculture through improved ammonia production processes. I am just unable to work on it because of life. And I really don't want to start another company at this point.
Re: The dual PhD problem of today’s startups
#119Earlier quoted context omitted.
Unfortunately large companies invest much less in longer-term research than they used to. Bell Labs was a thing ... once.
Bell Labs was funded by a government-sanctioned monopoly. Calling it a "corporate lab" is incredibly misleading, but popular among corporate lab types.
Re: The dual PhD problem of today’s startups
#120In order to find new ground, you may find yourself needing to do something truly out of the ordinary. Try holding board meetings in Swahili. Try “running your business” (which loses context given the next few words) without the concept of ownership or property. Seek sources of knowledge and wisdom outside of the scientific method, religion, business schools, political systems. Of course these would obviously fail (see 3 above) in the current system. We don’t tolerate failure. And we like to see out-of-the-box thinking fail because it further validates our existence systems. We may very well be at a maxima for social and economic development. The cost to try something new would be tremendous. We’re also disadvantaged that we have homogenized culture and thought. Even the simplest changes may require a step back that would be considered another dark age.