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Glucosamine Supplementation Reduces All-Cause Mortality: Study

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Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#131

Post by Obi_Juan_Kenobi »

m0llusk wrote: post #120
faitswulff wrote: post #108

Earlier quoted context omitted.

The study says the participants were 62% female, overwhelmingly ate more vegetables and supplements, exercised more than the control group, were mostly white, as well as self reported glucosamine supplementation - without dosage information. Overall it might be more indicative of wealth, education, and fitness than the effect of glucosamine. The paper itself says it’s not able to differentiate the effect from lifesty…

That is possible but the large sample size may help. The study involved roughly a half million people with around one hundred thousand supplementing with glucosamine. With that many people and these big numbers the results are rather strong.

Sampling addresses variance, not confounding factors.

If the sample is not representative of the broader population, then in no way will any amount of sampling correct that error.

Observational studies often involve quite large samples, but they remain unreliable because it is extremely difficult to address all possible confounding factors. Experimental intervention is the gold standard for a reason, and absent the ethical or practical impossibility of experimentation, should be used here.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#132

Post by ramraj07 »

ve55 wrote: post #119
ramraj07 wrote: post #91

Earlier quoted context omitted.

Interesting you take rapamycin and a bunch of other stuff thats supposed to extend lifespan. I wish to see if you live longer but I'll probably die first lol. Serious questions: have you experimented with calorie restriction? Clearly thats THE method that works in every species. Second question: do you battle with depression? My current hypothesis is that any life extending drug will also inevitably lead to depressio…

Yes, I generally have been doing quite a bit of intermittent fasting, fasting, and caloric restriction. But not very strictly so, only sometimes. I have before, but I would say it's not too bad right now.

Interesting. I'll keep following you to see how things progress!

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#134

Post by xvilka »

GloriousKoji wrote: post #57
nazca wrote: post #48

I've given glucosamine to my dogs for years, and I can clearly notice a difference in their joint health and how stiff and sore they are after long runs ('long-run': 15-25 miles, measured on GPS collars). When I run out of glucosamine, or just drop off of giving it to them for whatever reason, I see them fall back pretty quickly. And when I restart them on it, I notice a response in a few days. I also give give them…

Purely anecdotal data but a I know a good number of dogs and cats that had really good results supplementing with glucosamine. As for me personally and few other friends and family, glucosamine supplements didn't have much of a noticeable effect.

Probably because we, humans, don't move as much as cats and dogs.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#135

Post by b0rsuk »

faitswulff wrote: post #108
andrewem wrote: post #3

The paper this is based on, which might be a better link: https://ard.bmj.com/content/79/6/829

The study says the participants were 62% female, overwhelmingly ate more vegetables and supplements, exercised more than the control group, were mostly white, as well as self reported glucosamine supplementation - without dosage information. Overall it might be more indicative of wealth, education, and fitness than the effect of glucosamine. The paper itself says it’s not able to differentiate the effect from lifesty…

The last time I did googling on efficiency of glucosamine (several years ago, to combat runner's knee) I only found clinical trials sponsored by companies which produce glucosamine. Who's sponsoring this study?

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#136

Post by _8ljf »

evo_9 wrote: post #55

If you are interested in digging into this stuff, and what really works medically/scientifically based on reviewed evidence and sources such as Cochrane Reviews, I can't recommend Dr Stanfields youtube channel high enough: https://www.youtube.com/c/DrBradStanfield/videos Also here is his video on Sulforaphane which Glucosamine activates. He goes into detail as to how this mechanism works. Because of his video/latest…

Glucosamine supplementation looked decidedly unimpressive a decade ago and I don’t imagine anything has changed since.

https://sciencebasedmedicine.org/?s=glucosamine

Still, I took a look at Dr Stanfield’s youtube channel (because nothing says “primary source” like a YT link):

    As a side note, here's all the supplements I currently take (affiliate links):
    WAKE UP:
    • Sulforaphane 8mg ( https://amzn.to/… )
    • Niacin 50-500mg ( https://amzn.to/… ) - start low to help with flushing
    WORKOUT:
    • Creatine 2.5g before & after ( https://amzn.to/… )
    BREAKFAST:
    • Vitamin K2 MK-7 90μg ( https://amzn.to/… )
    • Vitamin D3 3,000 IU ( https://amzn.to/… )
    • Omega-3 (DHA/EPA) two capsules ( https://amzn.to/… )
    • Trans-Resveratrol 500mg ( https://amzn.to/… or https://cntr.click/… )
    • Pterostilbene 150mg ( https://amzn.to/… )
    • Collagen 10g ( https://amzn.to/… )
    LUNCH:
    • Niacin 50-500mg ( https://amzn.to/… )
    • Trimethylglycine (TMG) 750mg ( https://amzn.to/… or https://cntr.click/… )
    NIGHT (one hour before sleeping):
    • Metformin 1 gram (only on non-workout days)
    • Melatonin 500mcg ( https://amzn.to/… )
    • Magnesium Taurate 125mg ( https://amzn.to/… )
    ONCE I can afford it (will take in the morning):
    • Nicotinamide Mononucleotide (NMN) 1 gram ( https://amzn.to/… or https://cntr.click/… )
Yeah, no. Oversold supplements for the neurotic well are a longtime health grift. 1PPM of actual science and medicine, diluted in 999,999PPM of ego-pampering, holy-rolling religion, and wishful anti-aging crap.

BTW, here’s what your own Cochrane link says, which suggests you didn’t even bother to read it yourself:

“The current evidence does not support the use of antioxidant supplements in the general population or in patients with various diseases.”

IANAD, but I advise you apply some skepticism to that burn ASAP.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#137

Post by hhas01 »

hirenj wrote: post #130

I wonder why we need to supplement glucosamine (e.g. to treat arthritis) when it is synthesised by the body from glucose in one of our basic metabolic pathways. I could only imagine this becomes a problem unless a) the enzymes responsible stop working or b) if the glucose gets shunted off to some other purpose. It’s also funny that chondroitin supplementation does the job too, because it actually contains no glucosam…

In absence of good, hard, scientific evidence of effects above and beyond placebo, I’m gonna go with “Cos it’s easy to bottle and it’s easy to sell”.

And profitable too, I have no doubt. Thanks to Orrin Hatch, US supplement peddlers don’t even have to prove their products are safe, never mind effective:

https://en.wikipedia.org/wiki/Dietary_Supplement_Health_and_...

I bet the oft-reviled Big Pharma (who, amusingly enough, are some of the biggest manufactures of supplements too) just wish all their products could enjoy such lax standards of regulation. Meanwhile, to everyone else, I wholeheartedly recommend The Poison Squad:

https://www.pbs.org/wgbh/americanexperience/films/poison-squ...

https://www.penguinrandomhouse.com/books/312067/the-poison-s...

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#138

Post by hhas01 »

Article title is gross overreach, if not outright wrong.

IANAS, but even I know Correlation does not mean Causation. The paper itself only says “associated with”, not “responsible for”. Being an observational study of self-selecting cohorts, even with the authors’ attempts to control the confounders will be massive.

Honestly, this is the standard of reporting I’d expect from yellow-bellied fish wrappers like the Daily Mail. Please do better.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#139

Post by tluyben2 »

jdhn wrote: post #97
ibobev wrote: post #94

All-Cause Mortality? Is it make you also somehow immune to fire arms for example? Just the title makes the article to view unserious.

>Is it make you also somehow immune to fire arms for example? No, you have to start off with daily injections of small arms fires (think .22 caliber) in order to begin building immunity. Over time you gain immunity and then can work your way up to larger calibers.

It is a Reddit worthy response, but it immediately made me think of a KungFu movie I saw in the 80s where the monks were trained to withstand gunshots (multiple) to their heart. Now I just cannot find what (incredibly bad but apparently memorable) movie that was!

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#140

Post by hrishios »

This is an impossible field to be working in - I know - and it's to do with the way our medical research and treatment systems are set up.

We began as a species focused on making sick people healthy, and it's the way the entire system works. It's near impossible to get studies approved that tackle aging and proactive healthcare with drugs, as they will largely need to look at the effects on people who are healthy now, but will almost assuredly die from dementia, Alzheimer's and heart disease.

I understand why it is the way it is, but it's frustrating to see the system wait until you have heart disease in your 70s before doing something about it.

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