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An LSD Trip “Off-Switch” May Be Coming Soon

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Re: An LSD Trip “Off-Switch” May Be Coming Soon

#131

Post by GuB-42 »

DyslexicAtheist wrote: post #86
entropyneur wrote: post #12

So no info on what it actually is. Just some company filing a patent. And the fact that they call it "a neutralizer technology" suggests that it's probably just a bunch of BS combined with previously known drugs to make it patentable. I'm pretty sure there's at least some published research on using at least one antipsychotic for that and mountains of "folk research" on using benzodiazepines.

I'm curious what would be the market for this? wouldn't that be an extremely niche scenario within the emergency-response medicine where people inexperienced with LSD who suffer a bad trip ask to be taken off it? afaik LSD isn't a drug that one is likely to OD from either.

The biggest problem with LSD is its unpredictability, and what I think is the main reason why it isn't used therapeutically despite having shown very promising results.

You can't reasonably OD from LSD but you can have bad trips. Some of them can be so overwhelming that they will cause lasting effect not unlike PTSD. If you can stop a trip dead in its tracks, that's one less risk. By having ways to counteract its various potential negative effects, you can improve the safety profile of the drug, and therefore make it more acceptable.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#133

Post by godelski »

TheSkyHasEyes wrote: post #98
DyslexicAtheist wrote: post #86

Earlier quoted context omitted.

I'm curious what would be the market for this? wouldn't that be an extremely niche scenario within the emergency-response medicine where people inexperienced with LSD who suffer a bad trip ask to be taken off it? afaik LSD isn't a drug that one is likely to OD from either.

People on or approaching a bad trip I assume. Just don't know who will bother having any on hand if this happens.

There seems to be growing interest in using psychedelics for medicine. Just last week I was approached by someone asking to sign for a ballot measure to approve the usage of psychedelics in clinical settings (with a medical professional on hand). If they are going to do that, I think said medical practitioner would be the perfect person to have this on hand.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#134

Post by indenturedsmile »

penagwin wrote: post #65
c22 wrote: post #56

Earlier quoted context omitted.

Anecdotally, I've used risperidone specifically to abort LSD trips on two occasions and found it quite successful both times. Now when I introduce people to LSD I give them a Risperdal to keep in their pocket "just in case", though to my knowledge none of them have had to use it.

Simply knowing you have a backup strategy if you panic can go a long way to preventing panic attacks. Psychiatrists sometimes do something similar where they write a script for a benzo, just one or two for your bag. Knowing you can control panic if it occurs goes such a ways in preventing panic at all.

Anecdotally, one of the best treatments for social anxiety I've found is to always know where the exits are. At a concert, identify the exit signs. In a conversation, have someone who can take over for you.

Knowing there's a way out of the situation can completely nullify the scariness of that situation.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#135

Post by LockAndLol »

>LSD has been classified in the vast majority of countries as a Schedule 1 illegal drug for more than 50 years, ever since the adoption of the United Nations' Convention on Psychotropic Substances.

>That scheduling means regulators believe the drug has "no currently accepted medical use" — and according to scientists from Imperial College London's Centre for Psychedelic Research, it's had a hugely negative impact on LSD research.

The US fucked up a lot of research forcing other countries to sign that convention.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#136

Post by thoughtpalette »

thoughtpalette wrote: post #72
forgotmypw17 wrote: post #26

Earlier quoted context omitted.

Or a bit of MDMA

Highly recommend not candy flipping from anecdotal experience if anyone's thinking about doing it.

Let me add due to the number of replies, that I was in a comfortable, safe setting with a consistent, trusted source.

I personally ran into an issue with _intense_ head pressure I've not experienced before and it was very discomforting.

As with all recreational drugs, your experience has many variables to make it pleasant or not.

So as much as I'd recommend against (and won't do it again), there's obviously great experiences to be had candy flipping.

YMMV

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#137

Post by goatsi »

W4ldi wrote: post #24
layoutIfNeeded wrote: post #21

Earlier quoted context omitted.

Benzos are given to hundreds of millions of people every year, so they're pretty safe in my opinion. But they must not be taken for longer than a few weeks and/or in high doses! Because if you stop them cold turkey, you can die from the withdrawal effects (seizures).

Thing with most drugs is - we barely know which long-term/not clearly traceable side effects they have. We have these big issues like heart attacks, strokes, cancer, mental issues, gene defects - all of which don't have obvious causes but surely increased with pollution, drugs and chemicals

We are starting to find out the long-term effects of benzos, and it doesn't look good: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325366/

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#138

Post by carapace »

thanatos519 wrote: post #59

What was wrong with Niacin? 1500mg of Niacin stops it in less than 20 minutes for me.

Yeah, FWIW, R. A. Wilson talks about how B3 was known anecdotally back in the 70's in "Sex and Drugs" as good for bad trips.

https://en.wikipedia.org/wiki/Sex,_Drugs_and_Magick

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#139

Post by c22 »

readarticle wrote: post #82
crishoj wrote: post #60

Earlier quoted context omitted.

In my experience, processed food of all sorts appears utterly weird and unappealing in this state. On the other hand, fresh fruit is usually marvellous.

Set and setting. Trip with some poor people who haven’t seen a fresh fruit since grade school and look out instead for the magical “fruit” drinks that taste of their literal colors.

On one trip I had a memorable and absolutely glorious time stuffing my entire mouth with Gushers[0] and taking deliciously fruity flavored bong hits.

[0] https://en.wikipedia.org/wiki/Fruit_Gushers

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#140

Post by proverbialbunny »

bambataa wrote: post #113
proverbialbunny wrote: post #99

Earlier quoted context omitted.

Meditation. There are certain kinds of meditation that light up the brain in a near identical way to magic mushrooms, though imho the experience is better. An advanced practitioner only takes about 20 minutes of meditation to get into that kind of state. They can stay in that state as long as they want, and they can strengthen it or weaken it even turning it off whenever they want.

Are you referring to jhana?

Yes
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