The old urban legend is that Vitamin D brings you down and Vitamin C, up. Milk if tripping too hard, orange juice to trip harder.
An LSD Trip “Off-Switch” May Be Coming Soon
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Re: An LSD Trip “Off-Switch” May Be Coming Soon
#52So no info on what it actually is. Just some company filing a patent. And the fact that they call it "a neutralizer technology" suggests that it's probably just a bunch of BS combined with previously known drugs to make it patentable. I'm pretty sure there's at least some published research on using at least one antipsychotic for that and mountains of "folk research" on using benzodiazepines.
This article suggests it's likely Ketanserin. https://newatlas.com/science/lsd-off-switch-mindmed-liechti-...
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#53Earlier quoted context omitted.
How about alcohol? I’ve only had one third of a trip and towards the end whiskey took some of the edge off.
In my experience, alcohol has no effect if taken mid-trip. Usually if I'm tripping I won't even notice the effects of alcohol at all; YMMV.
Agreed, and this goes for other substances too.
I took a few hundred or so micrograms a couple weeks ago. I did a dab weighing about .15g during the strong part, and I didn’t notice any perceptual shift at all.
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#54We already have one. Give someone having a bad trip a Xanax and they're good.
Or a bit of MDMA
MDMA will not reduce the effects of LSD but remove the element of fear and bring your imagination into more pleasant areas. This is something that Rick Doblin, the founder of MAPS, describes in the latest Tim Ferriss podcast.
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#55We already have one. Give someone having a bad trip a Xanax and they're good.
Interesting, I didn't know that. Now I wish I'd had a Xanax after my one trip which kept me awake until 4-5 am after taking acid around noon (otherwise it was an incredible day, it was just annoying not being able to sleep). Don't benzos have some pretty nasty side effects and/or dependency potential though? Maybe this drug is a bit more targeted / less risky?
Try smoking a bunch of strong weed to sleep after tripping, works better than alcohol for me, YMMV.
Strong indicas in particular, Gorilla Glue for example.
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#56note: i’m not a doctor or anything related. Wikipedia says “5-HT2A antagonists block the psychedelic activity of LSD”[0], so wouldn’t 5-ht2a antagonists like mirtazapine work well enough here? No idea as to how quickly the trip would be tempered, though [0]: https://en.m.wikipedia.org/wiki/Lysergic_acid_diethylamide
Yes, or at least it blocks effects if you take it pre-exposure. Risperidone, an atypical antispychotic, is also known for this. Some idiotic big pharma startup will try and milk this, rather than examining cheap existing medications. Plenty of medications block 5-HT2A, I think the important requirement here would be rapid absorption and high receptor occupancy.
Anecdotally, I've used risperidone specifically to abort LSD trips on two occasions and found it quite successful both times. Now when I introduce people to LSD I give them a Risperdal to keep in their pocket "just in case", though to my knowledge none of them have had to use it.
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#57The old urban legend is that Vitamin D brings you down and Vitamin C, up. Milk if tripping too hard, orange juice to trip harder.
That's a folksy legend indeed, where is that from? The 1960s?
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#58Earlier quoted context omitted.
Yeah marketing something widely known to make it palatable and "provide liability" isn't new. See e.g. Scott Alexander's piece on literal fish oil: https://slatestarcodex.com/2014/06/15/fish-now-by-prescripti...
There have been way too many scandals around supplement purity for me to buy into his narrative. Like if someone told me a given brand of fish oil supplements contained 10% of the stated dose, was rancid and full of heavy metals I wouldn't be the least surprised. But if a fish oil medicine had those issues, I would be shocked, because the consequences for the guilty party would be much bigger, a huge circus of lawsui…
If it's an fda approved drug, I'd be shocked. You see how strictly they're coming down on contamination in the antacid space. If it was a supplement calling itself a medicine with a "these statements have not been evaluated by the FDA" label, then I'd be surprised if it actually did contain what it says it does, and do what it promises to do
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#59What was wrong with Niacin? 1500mg of Niacin stops it in less than 20 minutes for me.
Re: An LSD Trip “Off-Switch” May Be Coming Soon
#60Earlier quoted context omitted.
How about alcohol? I’ve only had one third of a trip and towards the end whiskey took some of the edge off.
I've never been able to even contemplate eating while tripping and the idea of drinking alcohol while tripping turns my stomach, I find it much easier to just take some alprazolam or diazepam if things start getting out of hand. That's just me personally though, I've tripped with a guy who went and bought and ate a whole chicken while tripping...
In my experience, processed food of all sorts appears utterly weird and unappealing in this state.
On the other hand, fresh fruit is usually marvellous.