What no one has yet discussed is being a plasma donor to keep the bad proteins down that have accumulated over time. You can donate 1 pint plasma up to twice a week, they replace it with saline and return the red cells to you. If someone went weekly, say, they would sooner or later have removed all the old plasma by dilution with the new plasma that replaces it - I dont have any data on how many donations it would ta…
Diluting blood plasma rejuvenates tissue, reverses aging in mice
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Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#82Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…
A testable hypothesis for your idea: do women age slower than men.
Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#83What no one has yet discussed is being a plasma donor to keep the bad proteins down that have accumulated over time. You can donate 1 pint plasma up to twice a week, they replace it with saline and return the red cells to you. If someone went weekly, say, they would sooner or later have removed all the old plasma by dilution with the new plasma that replaces it - I dont have any data on how many donations it would ta…
Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#84Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…
I don't know but since I was young it always seemed intuitive that blood-letting ought to have some good effects. If xyz bad things buildup (say, heavy metals) exist in the blood stream, and you remove a few % of your blood stream to make new blood, haven't you removed some xyz bad buildup?
Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#85Earlier quoted context omitted.
This is getting flagged down as a dumb joke, but for those in the cheap seats, it's not entirely clear exactly how this differs. Presumably adding "adding albumin and water" is different than just "adding water". But why, exactly? And so on.
If you’ve never encountered someone with low blood albumin, it is a very serious problem. You get terrible edema all over. Albumin helps you not retain the water in your cells, and instead to get the fluid back into your bloodstream for excretion.
Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#86Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#87Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#88Earlier quoted context omitted.
> A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work, for a while; but it wasn't heavily optimized for. I think your/the hypothesis fails...take certain species of jellyfish that are biologically immortal, they don’t have blood at all. Coincidentally they are considered top of the food chain, so another knock to the hypothe…
I think she/he/it was referring more specifically to mammals and other animals with blood.
In either case, the hypothesis suggests animals should live longer in the wild than in captivity. So let’s take the only mammal that isn’t more likely to die from age/don’t die from old age, the naked mole rat. We don’t understand why they die and any given day there is a 1 in 10,000 chance they die at any age. In captivity they should have the same lifespan as lab rats (6 years); however, in the wild the have an average lifespan of 17 years and in captivity that expands to 30 years (again in contrast to the hypothesis where wild animals of the same species should live longer than those in captivity).
Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice
#89Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…
Blood donors?