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Diluting blood plasma rejuvenates tissue, reverses aging in mice

news.berkeley.edu

81–90 of 108 posts

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#81

What no one has yet discussed is being a plasma donor to keep the bad proteins down that have accumulated over time. You can donate 1 pint plasma up to twice a week, they replace it with saline and return the red cells to you. If someone went weekly, say, they would sooner or later have removed all the old plasma by dilution with the new plasma that replaces it - I dont have any data on how many donations it would ta…

And do you feel rejuvinated?

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#82
post #80
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

A testable hypothesis for your idea: do women age slower than men.

They certainly live longer

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#83

What no one has yet discussed is being a plasma donor to keep the bad proteins down that have accumulated over time. You can donate 1 pint plasma up to twice a week, they replace it with saline and return the red cells to you. If someone went weekly, say, they would sooner or later have removed all the old plasma by dilution with the new plasma that replaces it - I dont have any data on how many donations it would ta…

O- donors have the opposite option: The machine is configured to remove red cells and return plasma diluted with saline.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#84
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

I don't know but since I was young it always seemed intuitive that blood-letting ought to have some good effects. If xyz bad things buildup (say, heavy metals) exist in the blood stream, and you remove a few % of your blood stream to make new blood, haven't you removed some xyz bad buildup?

Yeah, but you've weakened your body's ability to manage whatever xyz bad buildup and are now asking it to produce more blood as well. IANAD, but I'm pretty sure the medical consensus is that it's a net negative stress on the body.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#85
post #21

Earlier quoted context omitted.

This is getting flagged down as a dumb joke, but for those in the cheap seats, it's not entirely clear exactly how this differs. Presumably adding "adding albumin and water" is different than just "adding water". But why, exactly? And so on.

If you’ve never encountered someone with low blood albumin, it is a very serious problem. You get terrible edema all over. Albumin helps you not retain the water in your cells, and instead to get the fluid back into your bloodstream for excretion.

I haven't. But the idiot in me wants to ask whether I could just drink loads of albumin in water and "dilute" myself that way, without all of this weird dialysis, etc. Presumably not, but why not, exactly?

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#87
post #9

Earlier quoted context omitted.

Some conspiracy theory, they have a price list. https://www.ambrosiaplasma.com/

this is amazing. how did you find this, and do you know of any other health/longevity tips?

Nope, I just heard about it in the news a while back.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#88

Earlier quoted context omitted.

> A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work, for a while; but it wasn't heavily optimized for. I think your/the hypothesis fails...take certain species of jellyfish that are biologically immortal, they don’t have blood at all. Coincidentally they are considered top of the food chain, so another knock to the hypothe…

I think she/he/it was referring more specifically to mammals and other animals with blood.

Why would you think they were referring specifically to mammals? Mammals isn’t mentioned once whereas species/animals is used very broadly In the context of very broad ideas of evolution.

In either case, the hypothesis suggests animals should live longer in the wild than in captivity. So let’s take the only mammal that isn’t more likely to die from age/don’t die from old age, the naked mole rat. We don’t understand why they die and any given day there is a 1 in 10,000 chance they die at any age. In captivity they should have the same lifespan as lab rats (6 years); however, in the wild the have an average lifespan of 17 years and in captivity that expands to 30 years (again in contrast to the hypothesis where wild animals of the same species should live longer than those in captivity).

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#89
post #65
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

Blood donors?

https://sciencenordic.com/body-death-denmark/frequent-blood-...
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