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Alterations in glutamate and the experience of ego dissolution with psilocybin

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Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#151
post #77

Earlier quoted context omitted.

Moderate does trips aren't for everyone. The HN crew is full of novelty-seeking, curious, open-minded explorers, already drawn to this sort of experience. Your average, vanilla soccer mom who is largely okay with life but struggles with panic attacks because her brain isn't great at damping the amygdala-cortical loop, may not necessarily be ready/interested in a trip through psychedelic space.

Meditation has similar effects - some people will have a single mind-blowing experience and a lot of their problems go away at once. Others practice for years and slowly whittle away at the sharper corners of their mind. The problem is, you may not know what type of person you are going to be till ten years in. I suspect the same is true of psychedelic dosing: some of those soccer moms may need a strong depersonaliza…

"The problem is, you may not know what type of person you are going to be till ten years in."

Very true. I used to fancy myself a psychonaut, then i got careless with 5-meo-dmt. Now i'm a teetotaler. Upon reflection i can't say i ever really liked tripping.

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#152

Earlier quoted context omitted.

Thanks for sharing, I'd like to add my own experience on LSD and the long-lasting effect of fear-of-death it can result in. I have taken LSD only three times and can't say I enjoyed it very much, but I still wanted to give it a chance. Last time I took a 1/2 of what was recommended for me to see how it goes, and the beginning was pretty enjoyable, I played League of Legends, and the mobs started walking on the wall b…

My experiences with psychedelics and cannabis (many decades ago now) were similar in that LSD or psilocybin were terrific on their own, but the addition of cannabis made it extremely unpleasant. I still find cannabis unpleasant now. I found cannabis very enjoyable before trying that combination. My advice for any explorers would be to not smoke cannabis while tripping.

I've heard so many anecdotes about how to steer acid trips by mixing with other drugs.

These candy flipping practices seem like a great way to die!

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#153
post #46

Earlier quoted context omitted.

>It seems that unless you live in the Bay area and are friends with certain organic chemists, your chances of getting good quality, real LSD are slim. Definitely not true. LSD is one of the purest recreational drugs you can buy. If it's LSD it's 'good' LSD. Occasionally dox or nbome are sold as LSD but even that is relatively rare. Also you can just order it online.

"Just order it online" make it sound like it's Amazon. In practice you're going to need BTC, a VPN, and several other safeguards.

Empire is just like Amazon

There was a time "just using Amazon" meant a whole setup that was not ubiquitous. People also are passionate about making darknet seem like a scary place, I've seen many askreddit threads about the "scariest thing you've seen on darknet" with anything to the contrary losing consensus very quickly. Found that odd and contrived.

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#154
post #46

Earlier quoted context omitted.

That is what puts me off trying LSD. It seems that unless you live in the Bay area and are friends with certain organic chemists, your chances of getting good quality, real LSD are slim. However, mushrooms are quite easy to grow.

>It seems that unless you live in the Bay area and are friends with certain organic chemists, your chances of getting good quality, real LSD are slim. Definitely not true. LSD is one of the purest recreational drugs you can buy. If it's LSD it's 'good' LSD. Occasionally dox or nbome are sold as LSD but even that is relatively rare. Also you can just order it online.

I think nbombs are being mixed with LSD

You gotta test. Don't dismiss the need to test.

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#155
post #6

Totally anecdotal but LSD made my depression significantly worse than improving it in any way. I had two proper trips and had a seizure kind of thing at the start of the second one due to the overwhelming visuals (not experienced anything like that before or since). EDIT: to expand, it made me very questioning of my own consciousness and gave me severe and persistent existential dread and fear of death to the point w…

Thanks for sharing, I'd like to add my own experience on LSD and the long-lasting effect of fear-of-death it can result in. I have taken LSD only three times and can't say I enjoyed it very much, but I still wanted to give it a chance. Last time I took a 1/2 of what was recommended for me to see how it goes, and the beginning was pretty enjoyable, I played League of Legends, and the mobs started walking on the wall b…

As others have noted, set & setting are hugely important as well as staying away from other intoxicants during the experience (unless you are experienced with LSD or in the care of someone to guide you through the trip). It's not surprising that the combination of the video game and weed would have this effect. I personally can't even look at a screen during a trip, it looks too cartoonish and just beyond uninteresting to me.

My personal rules for any LSD trip are: be in the company of others you feel comfortable being sober with (as in no drugs, not even weed or alcohol), be in a safe place or near a safe place you can get back to without much issue if things get overwhelming, relaxing music, lots of fresh fruit on hand. Oh, and make sure anyone you're with is not on any sort of anti-depressant. I've seen some bad mixes with SSRIs and psychedelics (primarily DMT).

You should be ready to go introspective during your trip. If things get overwhelming, lay down, focus on your breath, and remember you're tripping and that you will sober up in a few hours. Let yourself cry if you need to. The worst experiences come when you try to fight it.

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#156
post #6

Totally anecdotal but LSD made my depression significantly worse than improving it in any way. I had two proper trips and had a seizure kind of thing at the start of the second one due to the overwhelming visuals (not experienced anything like that before or since). EDIT: to expand, it made me very questioning of my own consciousness and gave me severe and persistent existential dread and fear of death to the point w…

That's rough. I'm sorry you're struggling with the aftermath. My own story may be relevant to you. FWIW: I was really into zen as a kid. Part of my rebellion against Christianity and leaving my church. Once while meditating, I accidentally had a pretty bad trip. (I can describe the actual trip separately.) I was completely unprepared, didn't even know such a thing was possible. It's kicked my ass ever since. From wha…

Apologies in advance for the wall of text, but this is a topic that has occupied a considerable portion of my attention for nearly 25 years. :)

If any of what I share here is helpful for someone, it will be well worth drifting significantly off topic and perhaps over-sharing my personal experience.

That said, my experience is my own - other people's mileage may vary depending on their background and personal makeup. Trust your intuition (and your doctor / therapist if you have one)!

From your comments below (about being able to notice yourself out of existence), it sounds to me like you experienced both udayabbaya-nana (knowledge of arising and passing away) and bhanga-nana (knowledge of dissolution), as well as the other dukkha-nanas (knowledges of suffering) that follow [1].

It also sounds like you are familiar with the Zen analogs for these Theravada terms - sharing them here mostly for other readers.

These are well-known and understood phenomena, at least in Buddhism. Some modern yogis refer to this territory as the "Dark Night", a term borrowed from St. John of the Cross' work describing the experiences from a mystical Christian perspective[2].

The Atlantic had a good piece on this (touching on some relevant research at Brown) several years back [3].

I went through something similar to what you've described here with meditation, and similar to what many others have described here with psychedelics.

It took years of searching, research and growth for me to process and integrate these experiences and return to both a stable, consistent meditative practice and enjoyable / helpful use of psychedelics, including cannabis (which gave me panic attacks for many, many years).

For anyone who is in similar territory but wishes they could continue exploring: Bhajan / Kirtan [4] (example [5]) and Yoga Asana were both incredibly helpful for me, as was a-melodious chanting of various mantra and stotra.

Coming at the problem as a programmer with some understanding of machine learning - I looked at chanting practices as training data for my own biological neural network. A way to re-wire my relationship with meditation / spiritual practices / ego death.

The transition from my atheistic Buddhist practice to a sort of mystical pluralist practice that integrates many traditions was an interesting one, for sure.

I stopped seeing "god" as an absurd, surely-non-existent (for everyone) personal entity and began recognizing "gods" as undeniably-existing (for me) hybrids of:

* helpful anthropomorphic representations of key truths

* helpful anthropomorphic representations for lawful phenomena

* at the highest level: helpful conceptual placeholders for things that are completely impossible for me to describe

As a former atheist, I slowly became more and more comfortable with this framework. I think this was a combination of having grown up in a religious environment; having mystical experiences, searching for answers and finding documentation (independently arising in many different traditions) that closely mirrored my experiences; and feeling like there was tremendous mind-shaping power in a shared subconscious framework transmitted through trance-inducing chants practiced by millions of people over many centuries.

Like many, I would encounter truths through various mystical experiences and find great relief - only to fall back into unhelpful habitual patterns later. A daily relationship with one's personal Gods (in whatever form they take for you) is a very powerful psychological anchor for remaining tethered to truths discovered through mystical experience.

Lectures by Ram Dass[6], talks by Mooji[7] and dharma talks from many different teachers at Dharma Seed [8] also helped considerably.

I have some conjectures rattling around in my mind about _some_ manifestations of mental illness having _some_ of their roots in the territory of ego death (or close brushes with it). Many of us live in a society where all of our basic needs are met and there is ample time for introspection. Moreover, many of us fill a good deal of our non-introspective free time with music, cinema and television which has been shaped (directly or indirectly) by artists and thinkers under the influence of mind-expanding drugs, leading to further introspection (at least this was the case for me and many of my peers).

That is, I don't think someone necessarily needs to even be a yogi to wander into Dukkha-nana territory. Though, to be sure, the proliferation of superficial "mindfullness" practices will add to the aforementioned dog pile of causes and conditions for initial "spiritual awakenings" (for lack of a better term).

I'd love to share my entire journey and more thoughts on this (including 8 years living and traveling in Asia, trying to find answers). One day!

Lastly: if you find yourself in this territory and things are really bad, there are resources available to you! Check out: https://spiritualcrisisnetwork.uk.

Shenzen Young also has really helpful advice about when it's time to seek help from a medical professional: https://www.youtube.com/watch?v=BQ5B70ac_9M

==

[1] - http://www.buddhanet.net/knowledg.htm

[2](pdf) - http://www.carmelitemonks.org/Vocation/DarkNight-StJohnofthe...

[3] - https://www.theatlantic.com/health/archive/2014/06/the-dark-...

[4] - https://en.wikipedia.org/wiki/Kirtan

[5] - https://www.youtube.com/watch?v=YBso7TPtvJU

[6] - https://beherenownetwork.com/category/ram-dass/

[7] - https://podcasts.apple.com/us/podcast/satsang-with-mooji/id1...

[8] - https://dharmaseed.org/talks/

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#157
post #88
post #77

Earlier quoted context omitted.

Moderate does trips aren't for everyone. The HN crew is full of novelty-seeking, curious, open-minded explorers, already drawn to this sort of experience. Your average, vanilla soccer mom who is largely okay with life but struggles with panic attacks because her brain isn't great at damping the amygdala-cortical loop, may not necessarily be ready/interested in a trip through psychedelic space.

I think the answer to that is to slowly increase the dose over a number of sessions. Starting out with microdosing to get used to the body feeling, then getting used to visual disturbances and the altered mental state, and then graduating to a level that can unlock new perspectives on self and the world. This absolutely has to be done by a trained professional with personal experience with the substance and who has a…

> This absolutely has to be done by a trained professional with personal experience with the substance and who has assisted with other guided sessions. It's not going to be a prescription that a doctor can throw at the patient and then check up on in a few weeks time.

Seems like a bang-up business model, along with all sorts of other regular-meetings-with-the-professional therapies. Biologics on the pharm side, or just plain old therapy on the practitioner side.

Industry has plenty of practice with "every month or two" doses, so I wouldn't be so cynical in the attempts to remove the side effects. "Can you do it without getting high" is something that would greatly expand the audience and give people a better experience.

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#158

Earlier quoted context omitted.

Powerful psychoactive substances shouldn't be taken by people who are not mentally 'balanced', meaning just fine, happy with themselves or similar. I know its easy to say in hindsight, many of us tried those things when we didn't think about it, and it worked better for some and less for others. I think the old set & setting has some proper meaning here and can vastly bootstrap the incoming experience. Having a calm,…

> Powerful psychoactive substances shouldn't be taken by people who are not mentally 'balanced', meaning just fine, happy with themselves or similar. Agreed, but part of the problem is that they're often framed by their proponents as a miracle drug that can cure you of depression, anxiety, and fear of death. So people with those problems will often self medicate with them. And for some people, it totally works. But i…

I would say you shouldn't have your first trip unless your mental health is stable, or it is in a therapeutic context.

Once you have some sense of what to expect you can more readily use your judgment as to whether you're in the right headspace. I find it can be quite helpful to mitigate mild/moderate anxiety or depression.

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#159

Earlier quoted context omitted.

I suffer from diagnosed generalised anxiety disorder (GAD). Weirdly that second trip was actually much more relaxed and enjoyable during the trip than the first alone with just my wife on the canal boat, even if I did almost pass out at the start.

Thinking back, your experience of the seizure thing sounds similar to what a friend of mine experienced, not with LSD but MDMA. It is possibly related to the motion sickness and brain poisoning reflex.[0] [0] https://en.wikipedia.org/wiki/Motion_sickness#Defense_agains...

Serotonin is involved in regulating the digestive system so if you take drugs that act on serotonin like LSD or MDMA symptoms like nausea are quite common.

Re: Alterations in glutamate and the experience of ego dissolution with psilocybin

#160
> Whereas higher levels of medial prefrontal cortical glutamate were associated with negatively experienced ego dissolution, lower levels in hippocampal glutamate were associated with positively experienced ego dissolution.

This is interesting. Is there any practical techniques on how to induce the latter form of ego dissolution?

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