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Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

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Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#121

Post by ncmncm »

bsder wrote: post #53
vikramkr wrote: post #9

Here's the original publication. The paper is actually more focused on the 3d engineered brain model and is titled "A 3d human brain-like tissue model of herpes-induced Alzheimer's disease": https://advances.sciencemag.org/content/6/19/eaay8828 The publication actually seems to highlight the demonstration of the 3d brain Alzheimers model as more of what the accomplishment of the paper is (as compared to a demonstrati…

This is good because it helps continue to break down the whole "amyloid hypothesis" stanglehold on Alzheimer's research and we might finally start seeing some progress. This is not the whole story, but it's a ray of sunshine to get medical scientists moving in a another direction.

Question is what two generations of amyloid experts will do with their careers once it is seen that amyloids are just a response to a problem, not the problem. Discover new prions, maybe?

But the first priority has to be to get the purse strings and publication barriers out of the hands of amyloid partisans. Anybody deep in amyloids will have some time to find another gig, because the whole Amyloid Industrial Complex will take an appalling length of time to dismantle. Peer reviewed publication and grants are profoundly conservative, with only very occasional exceptions.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#122

Post by ncmncm »

benibela wrote: post #73

Didn't they discover that periodontitis causes Alzheimer: https://advances.sciencemag.org/content/5/1/eaau3333 Perhaps any infection that reaches the brain can cause Alzheimer and amyloid-beta plaques are there to fight the infection

Medical people mostly find the correlation unpersuasive, mostly because poor dental hygiene correlates strongly with all kinds of illnesses that break down ability to self-maintain.

I.e, it is just as likely that Alzheimer's causes periodontal complications.

That said, those bacteria do find their way to parts of the body that are protected against the immune system, and the brain would be an excellent host site.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#123

Post by ncmncm »

mylons wrote: post #5
TheSpiceIsLife wrote: post #4

Earlier quoted context omitted.

It means you’re not getting enough lysine at those times.

Source on info? Can you supplement with lysine?

I used to supplement with a huge oversupply of lysine, enough that I could smell it on my skin, and taste it in my saliva. I could never detect any effect, whether shortening an outbreak, reducing severity, or preventing an outbreak. I have had to conclude that nerve cells that host the virus manage to keep excess lysine outside the cell.

A peanut or nut binge would definitely worsen an outbreak, though.

Oral acyclovir also has no effect on the strain(s) I have. I have had an outbreak start while taking acyclovir prophylactically, and proceed through the whole cycle.

Valacyclovir 1000mg still works. Initially, one tablet. Now, 2 or 3.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#124

Post by ncmncm »

paypalcust83 wrote: post #77

I worked with a guy researching the functional basis of Alzheimer's synthesizing many radiological technologies. It is likely a multi-factor pathological degenerative condition with many, many potential precipitating (no pun intended) causes, both nature and nurture. "The cure" is more than likely a holistic combination of many early lifestyle modifications including, but not limited to: diet, sleep, exercise, gene t…

That has been said about every illness that has subsequently been shown to have a single cause.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#125

Post by vmception »

_prototype_ wrote: post #6

So according to WHO, 67% of people older than 50 have Herpes 1: https://www.who.int/en/news-room/fact-sheets/detail/herpes-s... How do you account for the disparity between the massive infection rate and the relatively low Alzheimer's rate?

The article covers this question, they think it is just a factor. A funnel towards Alzheimer's that a lot of people still end up getting to the bottom of.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#126

Post by vmception »

pharke wrote: post #90

So let me get this straight, the elevator pitch for this is: "We're going to make a micro-brain out of dick skin and spider webs so we can give it herpes and see if it gets Alzheimers." Just wanted to make sure.

Seems accurate! Since you read the article, the real question to me is what is the brain protecting against?

If amyloid plaques are a defense mechanism that happens to permanently block neuron function, then what happens if that the plaques don't form and the herpes infection spreads?

There doesn't have to be an answer, evolution doesn't cause improvements, people reproduce before this happens.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#127

Post by velosol »

DocG wrote: post #117
velosol wrote: post #44

Earlier quoted context omitted.

Have you intentionally exposed yourself to your previous triggers (assuming you had them)? How long has it been since you had the zoster vaccine? Were you of an on-label age for the zoster vaccine at receipt or was it off-label usage? Put another way did you receive Varivax or Zostavax dosing and were you in the on-label group (1-50 for Varivax and 50+ for Zostavax)? The data isn't great but there's a fair bit of ane…

I've had outbreaks but they were way less severe after that. I'm under 30. This recommendation came from doctor who specializes in herpes. She did warn me it might not work, but she has seen overall good results -outbreaks are less severe, rarer, or dissapear altogether. I think it's been around five years. There was a paper also on that, but couldn't find.

Thank you for the reply - I last looked into it for someone before the UCLA article came out and their doctor wasn't convinced by the French study but also wasn't completely against it. The person opted to not get the vaccine at that time. More and more it seems like the potential benefit is worth any side effects.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#128

Post by SequoiaHope »

toomuchtodo wrote: post #71
TaylorAlexander wrote: post #57

Earlier quoted context omitted.

I just don’t think wild speculation about science is fun. What is fun to me about science is fact based exploration. Hypothesis is great and conjecture has its place, but wild conjecture is not fun to me. You can feel otherwise and that’s okay!

I don't believe my original comment was wild conjecture (although it did lack a citation how I arrived at the hypothesis), but in keeping with your ideals as it relates to putting forth a thesis in a public forum: > We believe that HSV1 is a major contributory factor for Alzheimer’s disease and that it enters the brains of elderly people as their immune system declines with age. It then establishes a latent (dormant)…

Ah, you're probably right. I'm sorry, I believe I misunderstood. Well it would be great to figure out a vaccine for HSV-1 and HSV-2.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#129

Post by DocG »

velosol wrote: post #127
DocG wrote: post #117

Earlier quoted context omitted.

I've had outbreaks but they were way less severe after that. I'm under 30. This recommendation came from doctor who specializes in herpes. She did warn me it might not work, but she has seen overall good results -outbreaks are less severe, rarer, or dissapear altogether. I think it's been around five years. There was a paper also on that, but couldn't find.

Thank you for the reply - I last looked into it for someone before the UCLA article came out and their doctor wasn't convinced by the French study but also wasn't completely against it. The person opted to not get the vaccine at that time. More and more it seems like the potential benefit is worth any side effects.

I'm I EU if that matters and as far as I know, I have no sideffects. I was supposed to be healthy for both shots, that was the only requirement.

Why I'm sharing this information usually, because there are people out for who herpes is not annoyance but life disrupting virus. They often do not even know that there are antiviral drugs out there that work really well. They do think that there isn't much to do other than to suffer because when they were young or had bad doctor who said "oh everyone has it". My hope is maybe some people might go back to their doctor and say "please, it's disrupts my life" and they get appropriate treatment.

Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s

#130

Post by [deleted] »

nsxwolf wrote: post #58
hombre_fatal wrote: post #55

Earlier quoted context omitted.

What's your gameplan for the rest of your life? You're never going to kiss anyone or share a cup or a smoke or any of the thousands of ways that have infected the vast majority of humanity? You can even get it passing through your mom's birth canal. Your two examples of transmission are so specific that I'm not sure you know how it spreads. Just extended family members kissing or sharing cups with your kids? What? He…

I'm in the second half of my life and I married an HSV-negative. I try not to put my mouth on sketchy things.

[deleted]
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