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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#221

Post by learc83 »

woodpanel wrote: post #196
ArnoVW wrote: post #151

Earlier quoted context omitted.

The Lancet has published a study this week that anti-inflamatory drugs may help Ncovid penetrate cell walls and actually speed up the process. France has stopped over-the-counter sales of Ibuprofen as of mid January. https://www.afrinik.com/anti-inflammatory-drugs-can-make-cor...

This has been disputed: "This speculation about the safety of ACE-i or ARB treatment in relation to COVID-19 does not have a sound scientific basis or evidence to support it. Indeed, there is evidence from studies in animals suggesting that these medications might be rather protective against serious lung complications in patients with COVID-19 infection, but to date there is no data in humans. The Council on Hyperte…

The GP was talking about NSAIDS and you're posting about blood pressure medicine. There are similarities, but still.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#222

Post by marcosdumay »

stareatgoats wrote: post #189
greggman3 wrote: post #183

Earlier quoted context omitted.

Nirobi, Metro Area Population 10 million https://www.civitatis.com/en/nairobi/ Compare: Largest cities in Africa https://en.wikipedia.org/wiki/List_of_cities_in_Africa_by_po... Vs Largest cities in USA https://en.wikipedia.org/wiki/List_of_United_States_cities_b...

It's not a matter of big cities only. People in the big cities in industrialized countries spend their time indoors with large crowds to a much higher degree. It indicates that the spread will be slower in Africa (while not absent)

What exactly do you expect those 10M people to do during the day?

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#223

Post by vikramkr »

khafra wrote: post #216
ArnoVW wrote: post #151

Earlier quoted context omitted.

The Lancet has published a study this week that anti-inflamatory drugs may help Ncovid penetrate cell walls and actually speed up the process. France has stopped over-the-counter sales of Ibuprofen as of mid January. https://www.afrinik.com/anti-inflammatory-drugs-can-make-cor...

The Lancet article was not a study, it was a "correspondence," an educated guess from a researcher. https://www.thelancet.com/journals/lanres/article/PIIS2213-2...

I don't know if it's more responsible for the researchernto ouvlish their educated guess immediately - it's perhaps more likely than not to be right based on their expertise and they truley believe it's a really issue and might feel obligated to talk about it. Or, if it's more responsible to do the work first and get some preliminary evidence. Those few days during the pandemic could be crucial for rapid response, and if there's a strong rationale for it maybe it's worth communicating, but this isn't like "it can spread in xyz manner" that really changes behavior - you still be have to do social distancing whether or not Advil makes you more susceptible -is the panic that your painkiller will give you the coronavirus worth it?

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#224

Post by whatch »

devdas wrote: post #214
WhiteSage wrote: post #149

Earlier quoted context omitted.

In the east coast of Spain we have had great weathee (25+ degrees celsius) and it didn't seem to greatly influence transmission speed :(

The numbers so far suggest you need tropical heat and humidity to slow down transmission speed. That would need to be 35C+ weather, and no air conditioning.

Before I've read you message I was sure that dry air slows down transmission speed. But indeed, it's humidity https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3551767

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#225

Post by jackson1way »

Cantbekhan wrote: post #155
monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

And as discussed previously before in many submissions, hydroxichloroquine is already actively being used against Covid19 by at least the following EU countries: - Belgium - Netherlands - Switzerland - Italy

any source for this? especially how the success rate is in Italy? How many people received it etc.?

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#226

Post by ianai »

matwood wrote: post #191
ianai wrote: post #164

Earlier quoted context omitted.

Citation needed on it preferring colder climates. My own quick glimpse of the global numbers showed plenty of equatorial cases per capita. Many aren’t rigorously tested populations, too.

I think this presentation is a great source of facts. https://drive.google.com/file/d/1DqfSnlaW6N3GBc5YKyBOCGPfdqO... Weather: Maybe 10 oF increases the doubling time 2x (steady-state reduction in exterior virus levels by 50% per Pubmed 22312351, plus reducing time × concentration of people indoors). I don't think a paper about SARS-CoV-2 and temperature has been written yet (that I've seen), but people are hoping it…

“ It may also explain why some Asian countries in tropical area (such as Malaysia, Indonesia or Thailand) with high temperature and high relative humidity environment did not have major community outbreaks of SARS.”

Iirc, Maylasia has a pretty strong breakout on its hands. They recorded their first death today and are at something like 670 cases. I think their double rate was 2-3 days. Edit-it’s 1 day today. See link. Not good news I think for the hypothesis.

https://ourworldindata.org/coronavirus

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#227

Post by Lldjjxnn »

onetimemanytime wrote: post #215
londons_explore wrote: post #211

Earlier quoted context omitted.

Except drugs can be shipped around the world very cheaply, even in small doses, so demand alone can't explain price difference.

exactly. My point was this is prob a demand issue, not a government intervention. I wonder how fast they can make it...shipping can be done via charter planes this time.

False. Government prohibits importation of most medicines from abroad. It's corruption hidden in the form of "please just think of the children."

"FDA cannot assure the safety and efficacy of unapproved drugs" is the main excuse used in drug importation court cases.

Reference: https://www.pharmacycheckerblog.com/online-pharmacies-person...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#228

Post by arusahni »

CPLX wrote: post #197
andybak wrote: post #168

When I first went backpacking in the 90s I remember people were sharing stories about really disturbing nightmares from taking Chloroquine and generally complaining about mental and emotional side-effects. Google returns a bit of corroboration but that isn't mentioned on the Wikipedia page.

Are you sure you’re not talking about Malarone? That’s the other anti-malaria drug which has very intense and emotional dreams as a side effect.

Lariam (Mefloquine) was the one I took in the 90s that had the psychological warnings attached. IIRC, Malarone is newer, and may not align with the OP's timeline.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#229

Post by Khelavaster »

jcims wrote: post #23
cbhl wrote: post #17

Earlier quoted context omitted.

Under normal times, if you tell your doctor that you're planning on traveling, sometimes they'll ask if you want anti-malaria medication, and I believe chloroquine is one of the options they give you.

Yes my daughter got it on a trip to Tanzania last year.

Then you should go after the doctor for malpractice because malaria in East Africa is hydrochloroquine-resistant.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#230

Post by DennisP »

Lldjjxnn wrote: post #227
onetimemanytime wrote: post #215

Earlier quoted context omitted.

exactly. My point was this is prob a demand issue, not a government intervention. I wonder how fast they can make it...shipping can be done via charter planes this time.

False. Government prohibits importation of most medicines from abroad. It's corruption hidden in the form of "please just think of the children." "FDA cannot assure the safety and efficacy of unapproved drugs" is the main excuse used in drug importation court cases. Reference: https://www.pharmacycheckerblog.com/online-pharmacies-person...

But it wouldn't take an act of Congress to change that. Your link says it's up to the FDA, which could easily choose to allow importation to combat the pandemic.
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