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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#181

Post by jussij »

droithomme wrote: post #11
r6203 wrote: post #8

The publication is from 02/18/20 (as stated in the footer). Why didn’t gain it more traction?

> Why didn’t gain it more traction? It did. Since then they've done more studies, have started even more studies, and have deployed it en masse as a treatment. It's part of the official treatment recommendations in China, South Korea, Poland, and Italy. It's been described as a "cure" where it was used in Australia after Chinese patients demanded they be treated with it, and Australia is starting a nationwide trial.…

Here is more information regarding the possible Australia trial:

https://www.news.com.au/lifestyle/health/health-problems/cor...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#182

Post by drewcon »

JamesBarney wrote: post #73
spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

From wikipedia > In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult).[5] It is often recommended as a relief for leg cramps, but medica…

Challenge accepted!

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#183

Post by greggman3 »

stareatgoats wrote: post #162
codebolt wrote: post #143

Earlier quoted context omitted.

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

Nirobi, Metro Area Population 10 million

https://www.civitatis.com/en/nairobi/

Compare:

Largest cities in Africa

https://en.wikipedia.org/wiki/List_of_cities_in_Africa_by_po...

Vs

Largest cities in USA

https://en.wikipedia.org/wiki/List_of_United_States_cities_b...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#184

Post by stareatgoats »

dmos62 wrote: post #180
stareatgoats wrote: post #162

Earlier quoted context omitted.

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

I'd offer the Ebola outbreak as a counter-example.

Ebola is different: It does not spread over air like the Corona virus.

The Ebola virus " spreads to people initially through direct contact with the blood, body fluids and tissues of animals. Ebola virus then spreads to other people through direct contact with body fluids of a person who is sick with or has died from EVD". [0]

[0] https://www.cdc.gov/vhf/ebola/about.html

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#185

Post by stareatgoats »

kabouseng wrote: post #179
stareatgoats wrote: post #162

Earlier quoted context omitted.

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

I think you have a very Hollywood view of African societies...

Having lived in African countries for more than 5 years I don't rely on Hollywood for my sources.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#186

Post by matwood »

dreamcompiler wrote: post #105
spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

Quinine is one of the most bitter substances in the world. In capsule form it's not used much any more for malaria because the taste of the dust on the outside of the capsule made people throw up. The amount in tonic water is tiny compared to what you need if you have malaria.

I didn't vomit, but easily one of the worst pills I've ever taken - and I like bitter.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#187

Post by onetimemanytime »

joncrane wrote: post #178
j-james wrote: post #122

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

Ibuprofen can be manufactured by almost any company and sold in almost any store. So open competition in the sector drives down prices. Chloroquine exists in a walled garden where pharmaceutical companies and the government have rigged it so that rent-seeking behavior is the optimal financial strategy.

Why can't Chloroquine ? Maybe there's not as much money in it, unless it requires special permissions.

Does anyone know if there's a lot of supply in hand and if it can be made in large quantities fast?

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#188

Post by sandGorgon »

spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

To be more accurate - The cocktail was introduced by the army of the British East India Company in India.

Basically it was invented by the British to not die in India. We like to call it our national drink ;)

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#189

Post by stareatgoats »

greggman3 wrote: post #183
stareatgoats wrote: post #162

Earlier quoted context omitted.

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

Nirobi, Metro Area Population 10 million https://www.civitatis.com/en/nairobi/ Compare: Largest cities in Africa https://en.wikipedia.org/wiki/List_of_cities_in_Africa_by_po... Vs Largest cities in USA https://en.wikipedia.org/wiki/List_of_United_States_cities_b...

It's not a matter of big cities only. People in the big cities in industrialized countries spend their time indoors with large crowds to a much higher degree. It indicates that the spread will be slower in Africa (while not absent)

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#190

Post by maxerickson »

dmos62 wrote: post #180
stareatgoats wrote: post #162

Earlier quoted context omitted.

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

I'd offer the Ebola outbreak as a counter-example.

Only 2 Ebola outbreaks have had more than 1000 infected people.

This thing is in the early stages still and there are already 7x more recorded cases than the largest Ebola outbreak.

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