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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#161

Post by sandGorgon »

j-james wrote: post #122

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

btw, not sure if you cited the ibuprofen example merely as a comparison. I hope you are aware that early data is indicating that NSAIDs including ibuprofen have shown high degree of correlation with mortality in younger patients.

To an extent that the French govt has officially released it as a statement. https://edition.cnn.com/2020/03/16/health/coronavirus-ibupro...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#162

Post by stareatgoats »

codebolt wrote: post #143
j-james wrote: post #122

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#163

Post by john_minsk »

droithomme wrote: post #11
r6203 wrote: post #8

The publication is from 02/18/20 (as stated in the footer). Why didn’t gain it more traction?

> Why didn’t gain it more traction? It did. Since then they've done more studies, have started even more studies, and have deployed it en masse as a treatment. It's part of the official treatment recommendations in China, South Korea, Poland, and Italy. It's been described as a "cure" where it was used in Australia after Chinese patients demanded they be treated with it, and Australia is starting a nationwide trial.…

But Italy is a mess... So it is not an actual cure?

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#164

Post by ianai »

codebolt wrote: post #143
j-james wrote: post #122

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

Citation needed on it preferring colder climates. My own quick glimpse of the global numbers showed plenty of equatorial cases per capita. Many aren’t rigorously tested populations, too.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#165

Post by C1sc0cat »

cm2187 wrote: post #120

For French speakers, a talk yesterday from Didier Raoult who is also testing Chloroquine in France [1] (and I believe who originally discovered the anti-viral benefits of that molecule on certain viruses). He finds that it reduces significantly the viral charge. He made an interesting point. It appears infected people remain contagious for 3 weeks. Taking this drug allows to significantly reduce this period. The curr…

I must admit as an immune supressed individual - if (uk) they might suggest prophylactic meds for us.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#167

Post by [deleted] »

signa11 wrote: post #144
fspeech wrote: post #90

Earlier quoted context omitted.

This drug accumulates in various tissues, so for retinopathy what matters is the cumulative amount of the drug consumed over time.

oh man ! just like excess of vitamin-d can lead to vitamin-d toxicity, so can this. in my naïveté, i was assuming that excess of it would be just flushed out.

[deleted]

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#168

Post by andybak »

When I first went backpacking in the 90s I remember people were sharing stories about really disturbing nightmares from taking Chloroquine and generally complaining about mental and emotional side-effects. Google returns a bit of corroboration but that isn't mentioned on the Wikipedia page.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#169

Post by shermozle »

vinay427 wrote: post #147
baybal2 wrote: post #137

Earlier quoted context omitted.

Not uniquely. USA is famous for very high prices of essential medicines, and being an expensive country in general.

This was already implied in the question. They're asking why something like ibuprofen is different.

I'm assuming because ibuprofen is OTC and chloroquin is prescription.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#170

Post by Nursie »

spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

The amount of quinine in a G&T is negligible, unfortunately.

You're going to need more than one ;)

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