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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#171

Post by codebolt »

ianai wrote: post #164
codebolt wrote: post #143

Earlier quoted context omitted.

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

Citation needed on it preferring colder climates. My own quick glimpse of the global numbers showed plenty of equatorial cases per capita. Many aren’t rigorously tested populations, too.

It's something I first read from the Goldman Sachs client call notes that has been circulating:

https://www.forbes.com/sites/abrambrown/2020/03/16/the-priva...

Certainly not the best citation, and I have no idea where GS gets their analyses, but seems plausible enough that I'm at least hoping there could be some truth to it. See e.g. India, the virus doesn't seem to have taken off there despite a few early cases.

If it's wrong, I fear things could get really bad, especially in heavily populated cities like Lagos.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#172

Post by gordeh »

cm2187 wrote: post #136
ianbooker wrote: post #135

Earlier quoted context omitted.

Because testing everybody is no big deal.

According to Raoult, it doesn’t seem to be a technical limitation, the test is a standard procedure that labs around the country already do routinely for other viruses.

It's the capacity that is the issue. Testing labs all over the world, are running far above capacity already. It's not something that can be scaled up overnight either.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#173

Post by DrAwdeOccarim »

darawk wrote: post #133
spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

> As a cheap, safe bet it’s not unreasonable to start having a g&t each day along with a zinc pill. Make that a zinc lozenge , though. Zinc works by coating the esophagus, and killing the virus on contact there. Zinc pills that you simply swallow don't work at all.

Not true. Zinc has a proliferation effect on lymphocytes and monocytes that leads to positive outcomes in immune function. There have been a number of clinical studies on the topic. Here is one: https://academic.oup.com/ajcn/article/79/3/444/4690140

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#174

Post by nico_h »

ianbooker wrote: post #135
nico_h wrote: post #131

Earlier quoted context omitted.

that would make sense: test everybody, if positive take the drug for 5 days, rest for 2 more and back to work you go. a win for everybody!

Because testing everybody is no big deal.

Wasn’t there a $1 test being proposed? You can start by testing people with high temperature at the entrance of buildings and metro. Still cheaper that closing schools and all the rest of the economy.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#175

Post by hydroreadsstuff »

Quercetin is over-the-counter and has similar properties Studies according to the video below on Ebola and Zikka used 50-100mg/KG - a lot lot.

This Medcram video talks about Chloroquine and the others: https://www.youtube.com/watch?v=vE4_LsftNKM

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#176

Post by javiermares »

signa11 wrote: post #81
tiredofit wrote: post #62

Earlier quoted context omitted.

From wikipedia. One of the most serious side effects is a toxicity in the eye (generally with chronic use).[11] People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. The daily safe maximum dose for eye toxicity can be computed fro…

> ... has a cumulative dose of more than 1000 grams. ... woowza a Kg worth of drug !!! this doesn't look correct to me !

taken over the years

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#177

Post by hydroreadsstuff »

simpsond wrote: post #13

I just recently watched an interesting video about COVID-19, Zinc and Clororquine. It explains some of the fundamentals: https://www.youtube.com/watch?v=U7F1cnWup9M

The next episode 35 has some more infos on it, as well.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#178

Post by joncrane »

j-james wrote: post #122

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

Ibuprofen can be manufactured by almost any company and sold in almost any store. So open competition in the sector drives down prices.

Chloroquine exists in a walled garden where pharmaceutical companies and the government have rigged it so that rent-seeking behavior is the optimal financial strategy.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#179

Post by kabouseng »

stareatgoats wrote: post #162
codebolt wrote: post #143

Earlier quoted context omitted.

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

I think you have a very Hollywood view of African societies...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#180

Post by dmos62 »

stareatgoats wrote: post #162
codebolt wrote: post #143

Earlier quoted context omitted.

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

The rapid transmission in industrialized countries is most likely helped by the daily indoor concentration of people in the big cities, during commute, in large schools and workplaces. Large cities in Africa will surely get it to some extent, but the spread might be slower since Africans don't spend as much time indoors, and the rural communities are already practicing "social distancing" to some degree.

I'd offer the Ebola outbreak as a counter-example.
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