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The paper says clinical tests used both chloroquine and hydroxychloroquine. In discussing the results, they don't seem to differentiate between the two, unless I missed it.
When administering chloroquine, the hydroxy- form is a very long-lasting metabolite.
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Hydroxychloroquine is currently used by the Korean CDC for treating COVID-19
Source?
> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…
But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn out to be an unnecessary precaution.
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> ... has a cumulative dose of more than 1000 grams. ... woowza a Kg worth of drug !!! this doesn't look correct to me !
This drug accumulates in various tissues, so for retinopathy what matters is the cumulative amount of the drug consumed over time.
So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…
From wikipedia > In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult).[5] It is often recommended as a relief for leg cramps, but medica…
> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…
Not uniquely. USA is famous for very high prices of essential medicines, and being an expensive country in general.
does this mean it might be a good idea to be taking it regularly to keep from getting covid-19 from contact with surfaces with low concentration of the virus?
> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…
I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…
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Cheapish - as I recall about $300 for 90-day supply of generic hydroxychloroquine if paying cash in US. I mean, not cancer drug spends but if you are on it for life it’s an annoying annual expense.
US drug prices are pretty crazy. A random search in an internet pharmacy shows 100 tablets of 200mg hydroxychloroquine is like 30€ in Germany.