Earlier quoted context omitted.
Yes. Apparently the possible utility of chloroquine was discoevered because SLE patients on it in China weren't getting Covid-19 during the outbreak.
Source?
Chloroquine has shown apparent efficacy in treatment of Covid-19
111–120 of 269 posts
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#112Earlier quoted context omitted.
Cheapish - as I recall about $300 for 90-day supply of generic hydroxychloroquine if paying cash in US. I mean, not cancer drug spends but if you are on it for life it’s an annoying annual expense.
US drug prices are pretty crazy. A random search in an internet pharmacy shows 100 tablets of 200mg hydroxychloroquine is like 30€ in Germany.
I believe its around $30 in the US at Ralphs or Costco
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#113Earlier quoted context omitted.
To the plus side, its cheap. So, absent drug companies motivations to make cheap drugs (low) it is affordable at scale, and if it turned out to be useful e.g. early in the stage of the disease, this might be very good for wild infections. Or, maybe it points to drugs which are safer, equally cheap, and able to be made with less side effects. (see rule one: this is not medical advice)
Cheapish - as I recall about $300 for 90-day supply of generic hydroxychloroquine if paying cash in US. I mean, not cancer drug spends but if you are on it for life it’s an annoying annual expense.
Well, that reflects inflated American prices. In India, it is about 270 INR for 90x 200mg, or about $3.65. Non-generic hydroxychloroquine (Plaquenil) is about 3 times the price.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#114This is an increadibly potent drug with serious side effects according to anything I read, its not first-line treatment its last-line, when everything else fails. You can go blind, irreversibly. Please people, speak to trained medical people before reaching to the drug cabinet. I am not a doctor. This advice is not meant to contradict the rule of only taking medical advice from medical professionals.
I see this chloroquine thing all over twitter and elsewhere and I keep warning people to not take any without getting a doctor to ok it because of the side effect risk. Incredible what people will tell each other, your average griefer couldn't do much better.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#115This is an increadibly potent drug with serious side effects according to anything I read, its not first-line treatment its last-line, when everything else fails. You can go blind, irreversibly. Please people, speak to trained medical people before reaching to the drug cabinet. I am not a doctor. This advice is not meant to contradict the rule of only taking medical advice from medical professionals.
You can just buy it over-the-counter in some countries, right? How dangerous can it really be? Follow the instructions on the box like citizens of those countries do. IMO we in the US need to take the coronavirus as a wake up call to stop ignoring the medical systems of other countries and admit that they might have something to teach us. We shouldn’t just assume the American medical system is always the best one.
You can buy all kinds of super dangerous stuff in the cleaning aisle of your average supermarket. General availability is no indicator of toxicity. Ok, those are not made for ingestion. But even ignoring that factor you could list alcohol, tobacco and 30 different items from the grab-for-yourself stand at the local supermarket. You could likely kill yourself with just a handful of tablets from there if you knew what you were doing.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#116So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…
Chloroquine and quinine are different compounds.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#117So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…
> each day along with a zinc pill. The scientific studies being cited for these COVID-19 vaccines using Chloroquine specifically state zinc supplements by themselves are not ionized and are therefore useless for fighting the virus. Even though zinc entering cells is a key part of how it works, zinc can't enter the cells in question unless it's properly ionized, which is why they use Chloroquine... an ionized zinc del…
Pangolins aren’t the source and I’m not even gonna bother to explain.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#118So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…
From wikipedia > In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult).[5] It is often recommended as a relief for leg cramps, but medica…
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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#119Earlier quoted context omitted.
To the plus side, its cheap. So, absent drug companies motivations to make cheap drugs (low) it is affordable at scale, and if it turned out to be useful e.g. early in the stage of the disease, this might be very good for wild infections. Or, maybe it points to drugs which are safer, equally cheap, and able to be made with less side effects. (see rule one: this is not medical advice)
Cheapish - as I recall about $300 for 90-day supply of generic hydroxychloroquine if paying cash in US. I mean, not cancer drug spends but if you are on it for life it’s an annoying annual expense.
There are certain websites which will ship a 90-day supply for $10 plus change from India, paid with bitcoin. Just sayin'.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#120For French speakers, a talk yesterday from Didier Raoult who is also testing Chloroquine in France [1] (and I believe who originally discovered the anti-viral benefits of that molecule on certain viruses). He finds that it reduces significantly the viral charge.
He made an interesting point. It appears infected people remain contagious for 3 weeks. Taking this drug allows to significantly reduce this period. The current advice for people who are sick is stay at home and only show up at an hospital if you start having respiratory problems. He thinks a better approach is to get them to get tested quickly, and take a combination of anti-viral drugs. This will likely result in less contagions.
[1] https://www.youtube.com/watch?v=n4J8kydOvbc
[edit] Adding slides link posted by chmike on this page: https://www.mediterranee-infection.com/wp-content/uploads/20...
[edit] corrected contagiousness from 4 weeks to 3 weeks.