Chloroquine has shown apparent efficacy in treatment of Covid-19 • Hacker News Board

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#41

Post by beager » Tue, Mar 17, 2020, 5:04 AM UTC

I've seen chloroquine come up a ton and am hopeful for the efficacy of its use in treatment of COVID-19. It's surreal to be observing the global impact of a novel pandemic, and anything that can save lives or blunt the propagation of the virus feels like a gasp of hope.

Of course, chloroquine is not a vaccine, it's not a tool to contain the spread of SARS-CoV-2. We need massive and rapid propagation of testing, and meaningful progress toward a vaccine.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#42

Post by ridgeguy » Tue, Mar 17, 2020, 5:05 AM UTC

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

The paper says clinical tests used both chloroquine and hydroxychloroquine. In discussing the results, they don't seem to differentiate between the two, unless I missed it.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#43

Post by tanilama » Tue, Mar 17, 2020, 5:06 AM UTC

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

Hydroxychloroquine is currently used by the Korean CDC for treating COVID-19

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#44

Post by ggm » Tue, Mar 17, 2020, 5:06 AM UTC

This is an increadibly potent drug with serious side effects according to anything I read, its not first-line treatment its last-line, when everything else fails. You can go blind, irreversibly.

Please people, speak to trained medical people before reaching to the drug cabinet.

I am not a doctor. This advice is not meant to contradict the rule of only taking medical advice from medical professionals.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#45

Post by forkexec » Tue, Mar 17, 2020, 5:07 AM UTC

Watch out for Chloroquine retinopathy

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#46

Post by mirimir » Tue, Mar 17, 2020, 5:07 AM UTC

ridgeguy wrote: post #42

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

The paper says clinical tests used both chloroquine and hydroxychloroquine. In discussing the results, they don't seem to differentiate between the two, unless I missed it.

Damn, another hydroxychloroquine user here.

Maybe that'd ameliorate the <70 factor.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#47

Post by mundu_wa_hinya » Tue, Mar 17, 2020, 5:08 AM UTC

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

Keen to know this too. Hydroxychloroquine is the only common -quine drug in East Africa; odd but true, I think malarial chloroquine resistance has something to do with lack of demand/supply.

Additional possible drugs are alluvia, actemra. I think there's a study out for alluvia.

Things to avoid are aspirin (suspected basses on [1]) and ibuprofen (French govt recommendation).

Someone should come up with a summary page of the potential therapeutic drugs and their current state (suspected/in study/recommended)

Sorry for the brevity. On a phone.

1. https://academic.oup.com/cid/article/49/9/1405/301441?fbclid...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#48

Post by [deleted] » Tue, Mar 17, 2020, 5:08 AM UTC

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

[deleted]

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#49

Post by cdata » Tue, Mar 17, 2020, 5:08 AM UTC

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

(NOTE: I am not a medical practitioner, I'm just parroting what I was told in a video)

The Medcram video shared elsewhere in this thread (https://www.youtube.com/watch?v=U7F1cnWup9M) does mention that hydrochloroquine is a relative of chloroquine and is also being administered in some places when chloroquine is not available (at a different dosage). They take pains to point out that they should not be administered at the same time as that can lead to a fatal complication, and also that chloroquine as a treatment overall has not been subjected to a rigorous medical study.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#50

Post by random314 » Tue, Mar 17, 2020, 5:09 AM UTC

They haven't mentioned effect sizes or confidence intervals. Hopefully it is statistically significant - in which case the effect size has to be large to achieve statistical significance. I hope that is the case!