Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain • Hacker News Board

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#271

Post by teilo » Fri, Mar 06, 2020, 9:34 PM UTC

throwaway_tech wrote: post #257

teilo wrote: post #245

Earlier quoted context omitted.

GNG increases when in ketosis, but is still capped because ketones regulate the GNG process. That is the effect which was observed here. It says it right there in the synopsis: "Glucose concentration was lower (4·09 (sem 0·10) v. 4·89 (sem 0·06) mmol/l, P β-hydroxybutyrate is a ketone body. Note that this contradicts your statements that GNG will kick you out of ketosis. It absolutely will not. To repeat: GNG is cons…

>Note that this contradicts your statements that GNG will kick you out of ketosis. It absolutely will not. Its really simple, eat nothing but chicken and/or turkey (high protein, low fat, no carb). You will not become keto adapted or fat adapted. Alternatively enter into nutritional (dietary) ketosis with a high fat diet, then switch to chicken and/or turkey only (high protein, low fat, no carb) you will not remain i…

Yes I disagree with that. Dietary fat is not required to enter ketosis. On a lean protein diet, you will indeed go into ketosis, and your body will start using its own fat reserves to produce ketones. However, the transition to ketosis will be more difficult.

In fact, the biggest mistake keto dieters make is to assume that "fat doesn't make you fat". That's just wrong. On any high-fat keto diet you will burn dietary fat before burning your own fat. If weight lost is one's goal, it is essential to limit fat intake to moderate levels, just enough to keep you sated, so that the body is using its own fat reserves.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#272

Post by zadokshi » Fri, Mar 06, 2020, 9:35 PM UTC

ravenstine wrote: post #120

skizm wrote: post #102

Earlier quoted context omitted.

How does working out at a high intensity work when in a state of Ketosis? I lift weights and/or do HIIT 5x per week and occasionally add running on top of that. I've always been weary of going low carb or trying a keto diet because I feel like I just won't have the energy to continue my training regimen at its current intensity. The typical advice is to eat your allocated carbs 1-2 hours prior to your workout, howeve…

Depends on the diet. Low carb on its own can work because you can eat between 20 and 50 grams of carbs in a day, but ketosis is limited.(which might be okay depending on one's goals) Keto is shit for working out, in my personal opinion. Some people claim they can have effective workouts on keto, but I hate it, and a lot of others have a hard time having energy when training on keto. Keto is good for weight loss, and…

I don’t self test ketosis, it I believe I can eat slightly extra carbs during/post workout and not hugely interrupt ketosis. I don’t know if this is true, but certainly my body doesn’t feel ‘kicked out’ of ketosis when I do this.

(Keto vs non-keto is night and day for me, brain fog vs no brain fog, energy for life vs not being able to get off the couch)

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#273

Post by zadokshi » Fri, Mar 06, 2020, 9:38 PM UTC

sputknick wrote: post #110

skizm wrote: post #102

Earlier quoted context omitted.

How does working out at a high intensity work when in a state of Ketosis? I lift weights and/or do HIIT 5x per week and occasionally add running on top of that. I've always been weary of going low carb or trying a keto diet because I feel like I just won't have the energy to continue my training regimen at its current intensity. The typical advice is to eat your allocated carbs 1-2 hours prior to your workout, howeve…

Not the author, but I have experience with this. For me it takes about a week of slugishness before my body adjusts. Once I'm adapted, my performance is actually better. This goes for heavy weights, low weight/high rep weights, and cardio.

The first few times it was like this for me.

After years of doing keto I can get that keto feeling/energy/effect by doing one day of super low carbs and super low calories, I’ll wake up the next day wanting to spring out of bed like you wouldn’t believe.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#274

Post by hcurtiss » Fri, Mar 06, 2020, 9:39 PM UTC

windexh8er wrote: post #269

_brnu wrote: post #260

Earlier quoted context omitted.

I actually agree with most all of your posts. The one big difference, though, in my opinion, is that when adapted to a very low carbohydrate diet, it's actually easier for me to not eat. That's it. To me, it's the lone advantage. It's not about the palatability of the low-carb meals. It's that I just seem to be less hungry. I can skip a meal and it's no big deal. When I'm higher carb, missing a meal takes a way bigge…

When you state "very low carbohydrate diet" - what do you mean? Do you mean you're actively avoiding fruits and vegetables, oats, nuts, etc? Or are you avoiding processed foods and the carbs that go along with that? The "carbs are the devil" argument is a huge misconception with people. You mentioned that it's easier for you to not eat on a very low carbohydrate diet. My main eating regimen is two feeding periods tha…

By "high carb," I only mean to suggest easily-digestible high-glycemic index carbohydrates. I really do think there's something to the blood glucose spike and crash cycle and its relationship to satiety. I suspect you agree with that. However, whether through plants or other foods, I think it's the fat that most effectively satiates. You can get those fats through nuts and plant oils, but I find it's easier and tastier to get it through butter, eggs, and red meat.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#275

Post by zadokshi » Fri, Mar 06, 2020, 9:39 PM UTC

shitgoose wrote: post #200

tvjunky wrote: post #171

Earlier quoted context omitted.

Curious about your food choices. I've been experimenting with IF. More specifically I'd call it more like timed eating because the bulk of my fasting hours and during sleep. I'm down 20 lbs with solid numbers. As a side note I have some genetic factors as well and trying to counter those.

Same here, 10 kg down very quickly. Now weight is fixed at 80kg no matter what I eat. The only difference is when I eat.

Same, I went from 95kg to 80kg in a few months, then I got stuck at 80kg for a few months on keto. But then all of a sudden I dropped to 72kg in a few weeks (it was such an odd and rapid drop I freaked out and went to the doctors to get checked out)

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#276

Post by spion » Fri, Mar 06, 2020, 9:44 PM UTC

AnIdiotOnTheNet wrote: post #250

bad_user wrote: post #191

Earlier quoted context omitted.

I gave up because I felt awful ... problems sleeping, strong heart palpitations, hair falling off, left foot going numb, etc... all symptoms of nutrient deficiencies, which I couldn't correct via food or with supplements and that started disappearing within a week after giving up. And that entire time I did not lose weight, I actually gained a pound or two. If you're interested in losing weight, find a strategy for e…

> If you're interested in losing weight, find a strategy for eating less (by playing with what you eat or with meal timing). I'd just like to chime in and echo this sentiment. I myself have lost and kept off between 2 and 3 times what parent has and it was also no thanks to keto, or any fad-diet bullshit. There's no magic to losing weight. Consume less, expend more, weight loss ensues. Yes, it is that simple. No, tha…

This isn't quite true. For many, keto truly is an easier way to achieve the goal of eating less. Our metabolism uses various signals and pathways to detect satiety and even in the early stages of metabolic syndrome some of the pathways get broken due to insulin resistance (e.g. insulin blocking leptin satiety signaling in the brain).

Keto truly is much, much easier for many people. If you explore the keto community a bit, you will notice that it often naturally leads to intermittent fasting - simply because people don't feel like eating all that often.

Of course, it comes with its own difficulties with regards to food selection and social eating. However, in terms of willpower, my experience has been it's zero-effort compared to previous caloric restriction diets I've done.

This is not to say that caloric restriction takes a huge amount of effort and will-power for everyone. But if it does for you, it's worth checking keto out - and it's definitely not just a fad.

I've found that a fairly good selection criterion is people that suffer from post-meal slumps (sleepiness). If you are one of them, its likely that ketogenic diets will be helpful.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#277

Post by com2kid » Fri, Mar 06, 2020, 9:56 PM UTC

_brnu wrote: post #260

bad_user wrote: post #149

Earlier quoted context omitted.

> If you have never entered ketosis and experienced your brain running on ketones, I would suggest you experiment for yourself. I would say a minimum 2-3 months which should be enough time for your microbiome to change and your body/brain to adapt primarily running on ketones. I've been on Keto for about 8 months (before giving up), measuring my blood ketones and being in deep ketosis between meals (over 2 mmol/L). I…

I actually agree with most all of your posts. The one big difference, though, in my opinion, is that when adapted to a very low carbohydrate diet, it's actually easier for me to not eat. That's it. To me, it's the lone advantage. It's not about the palatability of the low-carb meals. It's that I just seem to be less hungry. I can skip a meal and it's no big deal. When I'm higher carb, missing a meal takes a way bigge…

I disagree a bit about the zone 4 thing.

https://imgur.com/a/HvHcOFV

I quit that workout because I got /bored/.

I've done 4 hour MMA training sessions in Keto, no endurance issues at all, no HR strap though so no #s.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#278

Post by mountain_peak » Fri, Mar 06, 2020, 10:04 PM UTC

throwaway_tech wrote: post #242

bad_user wrote: post #237

Earlier quoted context omitted.

> There is plenty of work showing that physical endurance increases after extended periods on keto Not really. Yes, athletes do suffer an adaptation, but it's basically about returning to near baseline levels (i.e. from sucking badly to sucking less). And as a matter of fact, the peak performance never recovers to full capacity ;-) Here's a list of studies on this subject — all of them showing a dicrease in performan…

>Yes, athletes do suffer an adaptation You admit and acknowledge an "adaptation" in this comment, but in another reply to me where I talk out the keto adaptation, you replied: >everything you're saying is a complete myth. Define what it means for the cells to adapt for "running on ketones". There's no such thing. As previously provided: A ketogenic diet (KD) involves using fat, a high-density substrate, as the main s…

Not claiming that the science is settled, but I when I entered keto over 10 years ago (TL:DR daily 10K+ 'performance' runner, neuropathy from glucose intolerance - genetic, avoid all drugs), I wanted to be sure that I could run without ingesting carbs (since everyone said you couldn't).

Read "The Art and Science of Low Carbohydrate Performance" and can absolutely say that after an initial horrible period that lasted for months, I was eventually able to run further and just as fast as I used to when I was carbo-loading. I can honestly say that running is more difficult now - my legs are generally sore and I don't feel like I'm 'flying along', but I've always tracked my times with Garmin, then Apple, and the stats belie how I feel.

From the book: "[Keto-adaptation] allows even a very lean (10% body fat) athlete access to more than 40,000 kcal from body fat, rather than starting a prolonged event depending primarily on ~2000 kcal of glycogen."

I think the studies you quoted would back-up the authors, but I also wanted to lend my long-term personal experience. I can't recall where I read it, but thought adaption also occurred in leg muscles where they found a massive increase in the number of mitochondria for athletes on keto.

I tested myself daily for years until I found a combination of diet and exercise that worked. My body definitely adapted and became much more efficient at burning fat - there's no performance 'wall' anymore, but I think the experience is different for everyone.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#279

Post by dhimes » Fri, Mar 06, 2020, 10:10 PM UTC

lubonay wrote: post #223

wirrbel wrote: post #141

Earlier quoted context omitted.

when was your last test before the one you had?

That's a very reasonable question - for all we know, the numbers might have been even worse!

Indeed- it was about a year prior.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#280

Post by 5cott0 » Fri, Mar 06, 2020, 10:13 PM UTC

wtetzner wrote: post #181

5cott0 wrote: post #87

I still don't understand the tech bro fascination with disordered eating.

Given the current state of health in western countries, I would claim the stasus-quo is actually disordered eating.

Current status quo is whatever quick fix is fashionable at the moment, i.e IF, Ketosis, Binge & Purge...