Earlier quoted context omitted.
Sugar and insulin response are critical to weight loss. The more overweight, the more you're insulin resistant, the harder it is to actually lose weight. Once you hit metabolic syndrome you've got a big problem on your hands. The CI-CO model is not sufficient to model weight loss effectively. Especially since with caloric restriction your BMR slows down to match your reduced intake (which doesn't happen with fasting,…
That's an extreme overgeneralization that's wrong in just the right places to be misleading. While there is a reduction in energy expenditure associated with the reduction of caloric intake, it is not equivalent to the reduction in caloric intake. For instance, in a study of obese women, a reduction of (4.3 +-(4.6) kcal/kg) was observed in a calorie restriction diet of 20kcal/kg Similarly, in a different study, a 30%…
I didn't mean to imply that it was 1:1, just that the model doesn't hold entirely.
> CI-CO is not a perfect model, in that it doesn't perfectly estimate weight loss rates, but the general concept holds true.
In general, I suppose, however most people aren't trying to lose weight but rather fat. Consuming sugar causes a spike in insulin, and insulin triggers the uptake of sugar in the blood by adipose tissue as fat, and actively prevents the release of fats stored therein. [1]
So in the most literal sense, CI-CO works, in that (net of the 16% reduction in TEE relative to your reduction in CI per your data) you're going to need to get the calories from somewhere. However, if you eat 30% less calories than your BMR entirely as sugar, you're much more likely to be burning alcohol, glycogen and protein than fat, certainly in the near term.
If you combine that with the "eat 6 meals per day" fad and you're in for a seriously tough time losing fat. On the other hand if you at 30% less calories than your BMR entirely as sugar in one sitting over 20 minutes and fasted the remaining 23h30 you may actually lose fat, since that'll give your body time with low insulin levels.
Let me re-state: CI-CO is a very inadequate model for losing fat.
[1] https://www.diabetes.co.uk/news/2018/jan/drop-in-both-insuli...