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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#101

Post by wallace_f »

eigenvector wrote: post #12
Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

I recently went to the doctor with a shoulder strain and without even looking at it he prescribed 1000mg daily for 2 weeks then "come back if it still hurts".

It's so bizzare how in order to do this, that person had a barrier to entry of hundreds of thousands in private and public resources getting a license to help you. And they dont really help you.

Compare to something like cops, who you have to interact with whether you like it or not, virtually have a license to kill, and are actually selected based on low IQ.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#102

Post by frostburg »

logicchains wrote: post #62
sergiotapia wrote: post #43

Earlier quoted context omitted.

Same just did that. >resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Fuck that. I wonder what I should give my kids when they have fevers though

>I wonder what I should give my kids when they have fevers though You don't have to give them anything. Ibuprofen doesn't make the underlying infection causing the fever go away any quicker, it just alleviates the symptoms. It's a trade off between reducing short-term suffering and risking long-term defects. Personally my parents never gave me painkillers for fever and I'm grateful for it: fever pain is just a tempor…

Your parents probably aren't doctors. The issue isn't cut and clean... To a point a moderate fever usually helps your immune system (the response exists for a reason), but anything other than a moderate fever can be a lot more dangerous than long term issues stemming from sporadic usage of antipyretics.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#103

Post by zzz95 »

sergiotapia wrote: post #43
michaco33 wrote: post #3

Earlier quoted context omitted.

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

Same just did that. >resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Fuck that. I wonder what I should give my kids when they have fevers though

Ordinarily, you should not try to suppress fevers. Fevers are beneficial and in fact, body's defense mechanism [1].

[1]https://www.health.harvard.edu/diseases-and-conditions/fever...

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#104

Post by babuskov »

sergiotapia wrote: post #43
michaco33 wrote: post #3

Earlier quoted context omitted.

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

Same just did that. >resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Fuck that. I wonder what I should give my kids when they have fevers though

> I wonder what I should give my kids when they have fevers though

You can use any drug containing Paracetamol (Tylenol, Panadol). It isn't that effective, but it works and as far as we know it's perfectly safe if you adhere to dosage recommendations.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#105

Post by DoreenMichele »

sergiotapia wrote: post #43
michaco33 wrote: post #3

Earlier quoted context omitted.

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

Same just did that. >resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Fuck that. I wonder what I should give my kids when they have fevers though

If it's not over 102 F and it's not interfering with sleep, you can bring a fever down some with plenty of fluids and/or a tepid bath.

My sons hated taking medication. I gave them non drug options on a routine basis for minor ailments because they didn't want to take drugs if they didn't have to.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#106

Post by wisdomteether »

rixrax wrote: post #64
gonyea wrote: post #9

Earlier quoted context omitted.

I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.

This. Just had friends visiting. Their teenage son had had his wisdom tooth pulled last week. Dentist had then given him (as a standard practice?) prescription for Ibuprofen (800mg tabs?) AND some opioid based pain killer! Needless to say, latter they said went directly to trash after they realized what it contained and for ibuprofen they halved the dosage. To me and his parents this was pain management gone way over…

I had a similar experience. My oral surgeon, who did a great job, highly recommended I fill the painkiller prescription and take it. He recommended this several times throughout the process, before and once before I left, as did the nurses (?) at the counter, as I expressed some concerns about it.

I finally caved and then took a half dose right after the extraction because I was fearing terrible pain, especially since the surgeon said mine was a fairly difficult job that would probably end up causing more pain than is typical.

The half dose of painkiller made me extremely nauseous, and so I decided to just try the 800mg of ibuprofen, and it did the job perfectly. I did feel a little sore and stiff, but never in pain unless I waited too long for another ibuprofen dose. It was the same for my girlfriend, who was also prescribed the pain killer but didn't take it because she didn't feel she needed it either.

The pain killer being prescribed didn't bother me per se, and neither did the recommendation, and I don't think anything nefarious was going on. Also, everyone's body is different. But given the side effects, and potential side effects, I just felt that even a simple "we recommend you get this prescription filled, but please see how the ibuprofen works first, and only take the pain killer if you can't handle the pain on ibuprofen alone" would have been a better way to handle it.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#107

Post by babuskov »

logicchains wrote: post #62
sergiotapia wrote: post #43

Earlier quoted context omitted.

Same just did that. >resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Fuck that. I wonder what I should give my kids when they have fevers though

>I wonder what I should give my kids when they have fevers though You don't have to give them anything. Ibuprofen doesn't make the underlying infection causing the fever go away any quicker, it just alleviates the symptoms. It's a trade off between reducing short-term suffering and risking long-term defects. Personally my parents never gave me painkillers for fever and I'm grateful for it: fever pain is just a tempor…

I didn't downvote you, but you seem to lack experience/knowledge on the topic if you think it's only a painkiller.

Ibuprofen's main use is to help to keep the body temperature in check. When your body temperature goes too high you can lose consciousness and even die. I had a very high fever once and didn't want to take any medicine until I started to lose consciousness and I almost fell while waiting in a line in pharmacy. I was able to go through it only because I was adult. Children are more fragile. Fever is the reason people died so much before discovery of antibiotics.

You are right that it alleviates the symptoms, and it's actually better not to use it when the temperature is moderate because high temp kills some germs. But if it goes too high, you have to stop it before it's too late.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#108

Post by myrandomcomment »

eaandkw wrote: post #22
Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

Clearly you have never been in the USMC. In hind sight it was pretty stupid but I have taken up to 1600mg per day for several days/ weeks in a row. We pretty much call the 800mg tablets grunt candy.

Same in the Army. Headache, 800mg. Arm blown off, 800mg. Sigh.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#109

Post by anonu »

jimmyswimmy wrote: post #6

Having read half the paper, the treatment group took 600mg ibuprofen daily for 14 to 44 days to induce the reported effect of compensated hypogonadism, though the 12 and 24 hour effects on testosterone were apparently easily detectable on ex vivo testicle samples. So, maybe if you need your testosterone, keep off the OTC pain medications. And probably don't donate samples of your testicle either. Interesting paper th…

Everything in moderation... Ibuprofen is probably okay for the occasional headache or pain, but avoid taking it daily... That is at least my MO.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#110

Post by komali2 »

babuskov wrote: post #107
logicchains wrote: post #62

Earlier quoted context omitted.

>I wonder what I should give my kids when they have fevers though You don't have to give them anything. Ibuprofen doesn't make the underlying infection causing the fever go away any quicker, it just alleviates the symptoms. It's a trade off between reducing short-term suffering and risking long-term defects. Personally my parents never gave me painkillers for fever and I'm grateful for it: fever pain is just a tempor…

I didn't downvote you, but you seem to lack experience/knowledge on the topic if you think it's only a painkiller. Ibuprofen's main use is to help to keep the body temperature in check. When your body temperature goes too high you can lose consciousness and even die. I had a very high fever once and didn't want to take any medicine until I started to lose consciousness and I almost fell while waiting in a line in pha…

But how is it better than an ice bath given the side effects of ibuprofen are potentially worse than an ice bath?
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